Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 405 time(s) and present in 388 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
CMRCameroon Podokwo0.291043See
ZAFSouth Africa Natal Zulu36.00.1950100See
SDNSudan South Nuba34.80.192546See
ITAItaly Sardinia pop30.1900100See
CHNChina Shandong Province Linqu County33.80.1863139See
SDNSudan Central Shaigiya Mixed33.30.183336See
CMRCameroon Uldeme0.171035See
ZAFSouth Africa Tswana31.70.159041See
GHAGhana Accre Asutuare Akan0.1510429See
TTOTrinidad African0.140067See
RUSRussia North Ossetian26.00.1339127See
BFABurkina Faso Mossi0.132053See
CMRCameroon Bamileke 20.129035See
USAUSA OPTN African American0.12801510See
SDNSudan Khartoum0.122498See
SAUSaudi Arabia22.20.117918See
FRAFrance Corsica Island0.1160100See
BRABrazil Parana Afro Brazilian22.10.110077See
ESPSpain Murcia0.1070173See
CHNChina Shandong Province0.20.10707418See
BFABurkina Faso Rimaibe0.106047See
TWNTaiwan Chinese immigrants from North China0.0980152See
BRABrazil Rio Grande do Sul Black0.0960248See
CHNChina Jiangsu Province0.091020248See
MEXMexico Mexico City West0.090933See
MARMorocco Casablanca0.0890100See
BRABrazil REDOME Bahia0.088747399See
GAZGaza Palestinians0.0840165See
MNGMongolia Tarialan Khoton0.082085See
MNGMongolia Hoton0.082085See
IRQIraq Arabs16.10.0805149See
MEXMexico Colima Rural0.079543See
MARMorocco pop 20.0770110See
ARGArgentina La Plata15.00.0760100See
BRABrazil REDOME Sergipe0.07577321See
MEXMexico Veracruz, Orizaba0.075060See
CZECzech Republic Kurd14.90.074374See
CHNChina Harbin Manchu0.0740172See
ESPSpain Gipuzkoa Basque0.0730100See
BRABrazil Sao Paulo Mixed14.00.0730239See
BRABrazil Minas Gerais State Mixed14.30.07301000See
TWNTaiwan Chinese immigrants from Middle China0.0720211See
CUBCuba Mixed Race14.30.071042See
BRABrazil South Ribeirao Preto0.0710184See
CUBCuba Mixed pop 20.0700189See
BRABrazil Piaui Mixed0.069021943See
BRABrazil REDOME Piaui0.068246140See
FRAFrance Bordeaux13.00.0661990See
BRABrazil REDOME Pernambuco0.064592332See
CUBCuba Mixed0.064078See
BRABrazil REDOME Rio de Janeiro0.0631139322See
BRABrazil REDOME Tocantins0.063020692See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.063096See
MEXMexico Sonora, Ciudad Obregón0.0629143See
MEXMexico Veracruz, Coatzacoalcos0.062555See
ITAItaly North Pavia pop 30.0622685See
MEXMexico Morelos, Cuernavaca0.061082See
BRABrazil REDOME Espirito Santo0.060688485See
BRABrazil REDOME Maranhao0.060510180See
CHNChina Shanghai0.060026266See
ITAItaly Rome12.00.0600100See
ITAItaly East Sicily12.00.060050See
RUSRussia Transbaikal Territory Buryats11.00.0600150See
MEXMexico Mestizo pop 40.0595269See
BRABrazil REDOME Alagoas0.059425349See
BRABrazil South East Cord Blood0.059111409See
BRABrazil REDOME Paraiba0.058343868See
MEXMexico Queretaro Rural0.058143See
BRABrazil REDOME Minas Gerais0.0580211275See
BRABrazil Sao Paulo Bauru Mixed0.05803542See
ESPSpain Sevilla11.50.0576278See
BRABrazil REDOME Rondonia0.057154396See
ITAItaly South Campania Region11.10.05711089See
RUSRussia Sakhalin Island Nivkhi0.057053See
DZAAlgeria pop 211.00.0566106See
MEXMexico Chihuahua Rural0.0565236See
COLColombia Barranquilla0.0560188See
ESPSpain Majorca and Minorca0.056090See
MEXMexico Sonora Rural0.0558197See
BRABrazil REDOME Mato Grosso0.055734649See
BRABrazil REDOME Acre0.0553859See
GTMGuatemala, Guatemala City Mixed Ancestry11.00.0551127See
CHNChina Shaanxi Province Han0.055010000See
ARGArgentina Buenos Aires10.70.0550466See
BRABrazil Para Cord Blood Unit10.90.0547841See
MEXMexico Nayarit Rural0.054764See
BRABrazil REDOME Sao Paulo0.0542800809See
BRABrazil REDOME Ceara0.0541101217See
CHNChina Wuhan9.90.0540121See
BRABrazil REDOME Goias0.053988574See
BRABrazil REDOME Mato Grosso do Sul0.053995667See
BRABrazil REDOME Federal District0.053829549See
BRABrazil REDOME Rio Grande do Norte0.053446603See
MEXMexico Campeche Rural0.053247See
BRABrazil REDOME Roraima0.05304140See
CMRCameroon Ewondo0.053038See
ITAItaly Bergamo9.90.0530101See
ISRIsrael Jews pop 210.20.052023000See
SAUSaudi Arabia pop 20.0520383See
BRABrazil Rio Grande do Norte Mestizo0.052012973See
IRNIran Royan Cord Blood Bank10.20.052015600See
INDIndia Jalpaiguri Toto10.00.051340See
ECUEcuador Amazonia Mixed Ancestry0.051339See
BRABrazil Para State10.00.05105000See
USAUSA OPTN Hispanic0.05101580See
KORSouth Korea pop 10.0510324See
ESPSpain, Castilla y Leon, Northwest,10.60.05061743See
MEXMexico Morelos Rural0.050030See
ITAItaly Lombardy9.80.0500674See
AREUnited Arab Emirates pop 29.70.0500373See
BRABrazil Rio Grande do Sul Mixed0.0500324See
MEXMexico Colima, Colima city0.049261See
MEXMexico Guanajuato Rural0.0491162See
BRABrazil REDOME Amapa0.049017864See
ESPSpain Majorcans Jews0.0490103See
TUNTunisia Ghannouch0.049082See
ARGArgentina Buenos Aires pop 29.20.04901216See
ITAItaly pop 69.20.0489184See
BRABrazil REDOME Para0.048872637See
ARGArgentina Cuyo Region9.30.0480420See
ESPSpain North Cantabria0.048083See
MEXMexico Zacatecas, Zacatecas city0.047684See
FRAFrance Marseille9.30.04661000See
MEXMexico Veracruz, Veracruz city0.0465171See
MEXMexico Mexico City Metropolitan Area Rural0.0461150See
ITAItaly North Pavia pop 29.00.04602416See
BRABrazil Parana Mixed race9.10.0460186See
MEXMexico Sonora, Hermosillo0.045599See
BRABrazil REDOME Amazonas0.045324129See
SAUSaudi Arabia pop 48.60.0451499See
KORSouth Korea pop 80.04507096See
ESPSpain Andalusia0.045099See
BRABrazil Pernambuco Mixed0.0450101See
MEXMexico Veracruz, Cordoba0.044656See
MEXMexico Jalisco, Zapopan0.0446168See
ECUEcuador Coast Mixed Ancestry0.0441238See
IRNIran pop 40.0439855See
MEXMexico Mexico City East0.043879See
MEXMexico Sinaloa, Culiacán0.0437103See
MEXMexico Tamaulipas Rural0.0437125See
MEXMexico Michoacan Rural0.0430348See
BRABrazil Curitiba-Parana Mixed0.0430264See
MEXMexico Zacatecas, Fresnillo0.0429103See
MEXMexico Jalisco, Tonala0.042935See
MEXMexico Durango Rural0.0428326See
MEXMexico Chihuahua Chihuahua City0.0420119See
PRTPortugal Beja0.0420699See
BRABrazil REDOME Parana0.0420341639See
ARMArmenia Yerevan0.0420445See
ARMArmenia living in Karabakh0.0420445See
ARMArmenia living in Lebanon0.0420368See
MEXMexico Durango, Durango city0.0419153See
CHLChile Santiago0.0418920See
MEXMexico Chihuahua, Ciudad Juarez0.0417106See
ESPSpain Majorca0.0410407See
VENVenezuela Caracas Mestizo0.040050See
GRCGreece Crete0.0400135See
CHNChina Harbin Korean0.0400201See
ESPSpain Catalonia Girona0.040088See
MEXMexico Coahuila, Torreon0.0400396See
BRABrazil Parana Cafuzo7.80.0390319See
FRAFrance Southeast7.70.0390130See
IRNIran pop 10.039064See
ARMArmenia Shirak0.039076See
ARMArmenia Lori0.0390102See
ARGArgentina Corrientes7.10.0390155See
MEXMexico Sinaloa Rural0.0383183See
MEXMexico Guerrero state0.0382144See
KURIraq Kurdistan Region7.20.0380209See
ARMArmenia Syunik0.0380117See
ESPSpain Minorca0.038094See
GRCGreece pop 70.037511250See
MEXMexico Jalisco Rural0.0375585See
ARMArmenia Ghegharkunik0.0370242See
PRTPortugal Faro0.03701242See
MNGMongolia Ulaanbaatar Khalkha0.037041See
BRABrazil Paraná Caucasian7.30.0367641See
MEXMexico Michoacan, Morelia0.0364150See
IRQIraq Erbil7.30.0363372See
FRAFrance Grenoble7.10.03621000See
ARMArmenia living in USA0.0360233See
MEXMexico Jalisco, Guadalajara city0.03561189See
FRAFrance Lyon6.90.03554813See
MEXMexico Nuevo Leon Rural0.0352439See
GRCGreece pop36.90.0351246See
MEXMexico Puebla Mestizo0.035099See
RUSRussia Northwest pop 37.00.0350100See
GBRUnited Kingdom North0.0348330See
MEXMexico Tapachula, Chiapas Mestizo Population6.90.034772See
BRABrazil REDOME Rio Grande do Sul0.0342241329See
PRTMadeira pop 30.0340538See
FRAFrance Reims0.0340102See
GEOGeorgia Kurds0.034030See
MEXMexico Jalisco, Tlajomulco0.033330See
MEXMexico Queretaro, Queretaro city0.033345See
MEXMexico Veracruz Rural0.0333539See
PRTPortugal South pop 20.03301021See
ESPSpain Arratia Valley Basque0.033083See
PRTPortugal Evora0.0330737See
PRTPortugal Portalegre0.03301254See
MEXMexico Mexico City Center0.0325152See
PRTPortugal Guarda0.0320797See
ESPSpain North Cabuerniga0.032095See
ISRIsrael Moroccan Jews0.0320113See
BRABrazil Parana Caucasian6.40.03202775See
MEXMexico Puebla, Puebla city0.03181994See
MEXMexico Aguascalientes state0.031695See
BRABrazil REDOME Santa Catarina0.0315106673See
BRABrazil Rio Grande do Sul Caucasoid0.03104428See
PRTPortugal Aveiro0.03105933See
ENGEngland London Ashkenazi Jews0.0310500See
FRAFrance Grenoble, Nantes and Rennes0.03106094See
ITAItaly North Pavia0.031081See
MEXMexico Mexico City Mestizo pop 30.0310256See
MEXMexico Nayarit, Tepic0.030997See
MEXMexico Tabasco, Villahermosa0.030582See
CHNChina Guangdong Province6.00.0304403See
SCOScotland Orkney6.00.030099See
PRTPortugal Porto0.03007937See
PRTPortugal Lisbon0.030017420See
PRTPortugal Setubal0.03005268See
PRTPortugal Vila Real0.03001167See
RUSRussia South Ural Tatar5.90.0300135See
MEXMexico Baja Californa, Mexicali0.0300100See
MEXMexico Zacatecas Rural0.0297266See
SVKSlovakia pop 20.02944234See
MEXMexico Mexico City Mestizo0.0290121See
PRTPortugal Coimbra0.02905057See
CHNChina Yunnan Province Han pop 20.0290129See
GRCGreece North0.0280500See
TURTurkey pop 50.0280142See
PRTPortugal Braga0.02801971See
RUSRussia Samara Region0.02802500See
RUSRussia Moscow0.02802650See
ENGEngland North West Mixed pop 25.50.0277379See
GBRUnited Kingdom South West0.0276163See
MEXMexico Coahuila, Saltillo0.027472See
MKDMacedonia MBMDR - Albanian5.50.0273128See
PRTPortugal Leiria0.02701847See
AUSAustralia West Caucasian5.30.0270891See
MEXMexico Oaxaca Rural0.0267485See
MEXMexico Veracruz, Xalapa0.0267187See
RUSRussia Moscow Pop 25.20.02602000See
ARGArgentina Salta Wichi pop 25.30.026019See
ESPSpain Andalusia Romani0.026099See
PRTPortugal Santarem0.02603865See
ENGEngland Liverpool5.10.02581343See
ENGEngland Newcastle5.10.02582739See
POLPoland pop 35.10.02572907See
MEXMexico Guanajuato, Leon0.025678See
MEXMexico Jalisco, Tlaquepaque0.025639See
ECUEcuador Mixed Ancestry0.02561173See
PRTPortugal Bragança0.0250301See
VENVenezuela Zulia Maracaibo Mixed0.025020See
VENVenezuela Zulia San Jose de Heras Mixed0.025020See
INDIndia Kerala Hindu Namboothiri0.025040See
GBRUnited Kingdom pop 20.0250101See
USAUSA OPTN Caucasian0.02508525See
MEXMexico Chiapas Rural0.0248121See
MEXMexico Hidalgo Rural0.024781See
ENGEngland Leeds4.80.02435024See
MEXMexico Tlaxcala Rural0.0241830See
DEUGermany Essen4.60.0240174See
MKDMacedonia pop 40.0240216See
RUSRussia Tatars0.0239355See
FRAFrance Rennes pop 44.70.02371000See
VENVenezuela Colonia Tovar0.023386See
PRTMadeira pop 20.0230173See
MEXMexico San Luis Potosi Rural0.023087See
PRTPortugal North pop 20.02291801See
MEXMexico Guanajuato, Guanajuato city0.022722See
GBRUnited Kingdom Orkney0.022688See
GBRUnited Kingdom Central0.0225135See
PRTPortugal Viseu0.02202915See
RUSRussia Northwest pop 24.40.0220346See
USAUSA OPTN Asian0.0220261See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks4.50.0220112See
GBRUnited Kingdom East0.0215163See
SRBSerbia pop 34.20.02111992See
PRTPortugal Castelo Branco0.0210327See
MNGMongolia Tsaatan0.0210144See
MNGMongolia Khalkha pop 20.0210202See
ENGEngland Manchester4.10.02071640See
ROMRomania pop 34.00.02051469See
MKDMacedonia MBMDR - Macedonian4.00.02031283See
ECUEcuador Andes Mixed Ancestry0.0200824See
MEXMexico Baja California, Tijuana0.020025See
SVNSlovenia pop 33.90.0200130See
SRBSerbia Vojvodina4.00.0200400See
FRAFrance Rennes pop 30.0200200See
THAThailand pop 40.020016807See
ROMRomania pop 20.02006936See
ISRIsrael Ashkenazi Jews pop 20.0200132See
TTOTrinidad South Asian0.020087See
MNGMongolia Khalkha0.0200200See
MEXMexico Nuevo Leon, Monterrey city0.0199226See
MEXMexico Mexico City North0.0199751See
LKASri Lanka Colombo Sinhalese0.0190101See
MEXMexico Chiapas, Tuxtla Gutierrez0.018952See
MEXMexico Yucatan Rural0.0187132See
ENGEngland Lancaster3.70.0186545See
ENGEngland Sheffield3.70.01864755See
RUSRussia Northwest3.70.01861011See
MEXMexico Coahuila Rural0.0183216See
MEXMexico Sinaloa Mestizo0.018056See
WALWales pop 23.50.018039979See
ARMArmenia living in Iran0.018085See
PRTPortugal Viana do Castelo0.0170706See
ESPSpain Ibiza0.017088See
MKDMacedonia pop 30.0170172See
PERPeru Arequipa Mestizo3.40.0170168See
HRVCroatia pop 33.30.0167120See
MEXMexico San Luis Potosi, San Luis Potosi city0.016730See
SWESweden pop 43.20.0161966See
TWNTaiwan Hakka pop 20.0160714See
PRTAzores Terceira Island0.0160130See
PAKPakistan Burusho0.016092See
INDIndia Kerala Syrian Christian0.016031See
MEXMexico Yucatan, Merida0.0154192See
MEXMexico Puebla Rural0.0150833See
INDIndia Kerala Malabar Muslim0.015034See
BRABrazil Parana Oriental3.00.015033See
TWNTaiwan Chinese immigrants from South China0.0150172See
INDIndia North Gujarat3.00.0148338See
IRLIreland South pop 20.014417624See
MEXMexico Tabasco Rural0.0141142See
RUSRussia South Ural Russian2.90.0140207See
RUSRussia South Ural Bashkir2.70.0140146See
PRTPortugal Center pop 20.0140562See
HRVCroatia pop 20.0140100See
ALBAlbania pop 22.80.0139432See
MEXMexico Baja California, La Paz0.013375See
SWESweden Uppsala2.60.0130300See
TURTurkey pop 20.0130228See
THAThailand Northeast pop 20.0130400See
ALBAlbanian Kosovo0.0125120See
MEXMexico Hidalgo, Pachuca0.012241See
COLColombia San Basilio de Palenque0.012042See
TWNTaiwan Minnan pop 20.01207137See
RUSRussia Chuvash0.012082See
MEXMexico Mestizo2.40.012041See
THAThailand Northeast0.012066See
INDIndia Kerala Hindu Nair0.012041See
INDIndia North pop 30.0110587See
MEXMexico Quintana Roo, Cancun0.010448See
BRABrazil Parana Japanese2.00.0104192See
NORNorway ethnic Norwegians2.00.01024510See
MEXMexico Baja California Rural0.010050See
MEXMexico Quintana Roo Rural0.010050See
BFABurkina Faso Fulani0.010049See
MYSMalaysia pop 30.01001445See
RUSRussia Arkhangelsk Pomor0.010063See
RUSRussia Murmansk Saomi Mixed0.010070See
MEXMexico Oaxaca, Oaxaca city0.0099151See
INDIndia sub-Himalayan West Bengal Kami1.90.0095158See
MEXMexico San Vicente Tancuayalab Teenek/Huastecos0.009453See
MEXMexico Huasteca Region Teenek0.009055See
RUSRussia Nenet Mixed0.008055See
MYSMalaysia pop 20.008062See
TWNTaiwan Minnan and Hakka0.0080190See
BGDBangladesh Dhaka Bangalee0.0070141See
SWESweden Stockholm1.50.00701347See
JPNJapan pop 20.0070916See
PAKPakistan Mixed Sindhi0.0060101See
BOLBolivia La Paz Aymaras0.006087See
ESPSpain Pas Valley0.005088See
USAUSA NMDP Black South or Central American0.00484889See
BIHBosnia and Herzegovina pop 20.80.0042120See
BIHBosnia and Herzegovina0.0037134See
JPNJapan Kyoto and Osaka0.0030165See
MEXMexico Tlaxcala, Tlaxcala city0.0028181See
RUSRussia Bashkortostan, Tatars0.50.0026192See
MEXMexico Mexico City South0.000052See
MEXMexico Campeche, Campeche city0.000034See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
MEXMexico Veracruz, Poza Rica0.000045See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.000094See
MYSMalaysia Negeri Sembilan Minangkabau0.000034See
MYSMalaysia Perak Rawa0.000023See
VNMVietnam Hanoi0.000050See
JPNJapan Hyogo Osaka and Nagano0.0000195See
TWNTaiwan Aborigine0.0000111See
MNGMongolia Oold0.0000104See
ARGArgentina Rosario Toba0.00.000086See
ARGArgentina Chiriguano0.00.000054See
CHNChina Yunnan Province Naxi0.0000118See
INDIndia Kerala Hindu Ezhava0.000024See
INDIndia Kerala Hindu Pulaya0.000016See
CHNChina North Han0.0000105See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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