Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 431 time(s) and present in 408 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
MEXMexico Oaxaca Rural0.3111485See
MEXMexico Quintana Roo Rural0.300050See
MEXMexico Guanajuato, Guanajuato city0.272722See
MEXMexico Veracruz, Cordoba0.267956See
MEXMexico Oaxaca, Oaxaca city0.2649151See
MEXMexico Yucatan Rural0.2612132See
MEXMexico Veracruz, Coatzacoalcos0.258955See
MEXMexico Puebla Rural0.2338833See
MEXMexico Veracruz, Poza Rica0.233345See
MEXMexico Quintana Roo, Cancun0.229248See
MEXMexico Tlaxcala, Tlaxcala city0.2210181See
MEXMexico Puebla, Puebla city0.22091994See
MEXMexico Yucatan, Merida0.2205192See
MEXMexico Tlaxcala Rural0.2157830See
MEXMexico Mexico City South0.211552See
MEXMexico Veracruz, Xalapa0.2086187See
ARGArgentina Chiriguano37.70.208054See
MEXMexico Veracruz Rural0.2070539See
MEXMexico Veracruz, Veracruz city0.1977171See
MEXMexico Mexico City North0.1959751See
MEXMexico Tapachula, Chiapas Mestizo Population30.60.194072See
MEXMexico Mexico City East0.193879See
PERPeru Lamas City Lama0.193083See
MEXMexico Michoacan Tarasco35.30.1920130See
MEXMexico San Vicente Tancuayalab Teenek/Huastecos0.188753See
MEXMexico Tabasco Rural0.1866142See
MEXMexico Huasteca Region Teenek0.185055See
MEXMexico Mexico City Metropolitan Area Rural0.1842150See
MEXMexico Guerrero state0.1840144See
MEXMexico Veracruz, Orizaba0.183360See
MEXMexico Campeche Rural0.180947See
GTMGuatemala Mayan0.1800132See
MEXMexico Hidalgo Rural0.179081See
MEXMexico Queretaro, Queretaro city0.177845See
MEXMexico Chiapas, Tuxtla Gutierrez0.169852See
MEXMexico Aguascalientes state0.168495See
MEXMexico Tamaulipas Rural0.1667125See
MEXMexico Sinaloa Capomos Mayo Yoremes0.166760See
MEXMexico Mexico City West0.164233See
MEXMexico Campeche, Campeche city0.161834See
MEXMexico Baja California, Tijuana0.160025See
MEXMexico Chiapas Rural0.1570121See
COLColombia Wayu from Guajira Peninsula0.156348See
MEXMexico Guanajuato, Leon0.153878See
MEXMexico Mayan Pop 30.151066See
MEXMexico Morelos Rural0.150030See
MEXMexico Nuevo Leon, Monterrey city0.1438226See
MEXMexico Morelos, Cuernavaca0.140282See
MEXMexico Puebla Mestizo0.136099See
MEXMexico Hidalgo, Pachuca0.134141See
MEXMexico Jalisco, Tlajomulco0.133330See
ARGArgentina Salta Wichi pop 226.30.132019See
MEXMexico Zacatecas, Zacatecas city0.131084See
MEXMexico Nuevo Leon Rural0.1307439See
MEXMexico Tamaulipas, Ciudad Victoria0.130423See
TWNTaiwan Aborigine0.1300111See
MEXMexico Mexico City Center0.1299152See
CMRCameroon Uldeme0.129035See
GTMGuatemala, Guatemala City Mixed Ancestry22.00.1260127See
MEXMexico Nahuas0.125072See
MEXMexico Guanajuato Rural0.1227162See
MEXMexico Baja California Rural0.120050See
MEXMexico Nayarit Rural0.117264See
MEXMexico Chihuahua, Ciudad Juarez0.1157106See
MEXMexico Jalisco, Tlaquepaque0.115439See
MEXMexico Colima Rural0.113643See
MEXMexico Mexico City Mestizo pop 30.1130256See
ECUEcuador Andes Mixed Ancestry0.1092824See
BOLBolivia La Paz Aymaras0.109087See
MEXMexico Coahuila, Torreon0.1088396See
MEXMexico Jalisco, Guadalajara city0.10721189See
CHLChile Santiago0.1071920See
ECUEcuador Mixed Ancestry0.10611173See
MEXMexico Sonora, Hermosillo0.106199See
MEXMexico Michoacan Rural0.1060348See
MEXMexico Zacatecas, Fresnillo0.1048103See
MEXMexico Jalisco, Zapopan0.1042168See
MEXMexico Durango Rural0.1040326See
MEXMexico Tabasco, Villahermosa0.103782See
ECUEcuador Amazonia Mixed Ancestry0.102639See
RUSRussia Nenet Mixed0.102055See
MEXMexico Sinaloa, Culiacán0.1019103See
MEXMexico Coahuila Rural0.1009216See
ECUEcuador Coast Mixed Ancestry0.1008238See
COLColombia Jaidukama0.096039See
MEXMexico Michoacan, Morelia0.0960150See
MEXMexico Mexico City Mestizo0.0950121See
MEXMexico Zacatecas Rural0.0948266See
CMRCameroon Bakola Pygmy18.00.094450See
MEXMexico Jalisco Rural0.0922585See
MEXMexico Colima, Colima city0.090261See
SAUSaudi Arabia16.70.087318See
MEXMexico Chihuahua Chihuahua City0.0840119See
MEXMexico San Luis Potosi, San Luis Potosi city0.083330See
BRABrazil Para Cord Blood Unit16.30.0832841See
ARGArgentina Corrientes14.20.0810155See
RUSRussia Arkhangelsk Pomor0.080063See
MEXMexico Baja Californa, Mexicali0.0800100See
MEXMexico Mestizo pop 40.0799269See
MEXMexico Sonora Rural0.0787197See
MEXMexico Durango, Durango city0.0774153See
MEXMexico Nayarit, Tepic0.077397See
ARGArgentina Cuyo Region14.60.0760420See
USAUSA OPTN Hispanic0.07601580See
BRABrazil Parana Oriental15.10.076033See
JPNJapan pop 1114.50.075362See
MEXMexico San Luis Potosi Rural0.074787See
MEXMexico Sinaloa Rural0.0738183See
MEXMexico Baja California, La Paz0.073375See
MEXMexico Sinaloa Mestizo0.071056See
BRABrazil REDOME Amazonas0.070524129See
BRABrazil REDOME Amapa0.070417864See
CMRCameroon Podokwo0.070043See
MEXMexico Sonora, Ciudad Obregón0.0699143See
COLColombia Barranquilla0.0640188See
BRABrazil REDOME Para0.063872637See
BRABrazil Para State12.70.06375000See
MEXMexico Coahuila, Saltillo0.061672See
ARGArgentina Buenos Aires pop 211.80.06101216See
TUNTunisia Ghannouch0.061082See
COLColombia San Basilio de Palenque0.060042See
BOLBolivia Quechua0.058069See
MEXMexico Jalisco, Tonala0.057135See
RUSRussia Sakhalin Island Nivkhi0.057053See
ARGArgentina Buenos Aires10.70.0570466See
BRABrazil REDOME Roraima0.05584140See
BRABrazil Belem Mixed11.00.0550100See
VENVenezuela Colonia Tovar0.052386See
VENVenezuela Zulia Maracaibo Mixed0.050020See
BRABrazil Curitiba-Parana Mixed0.0494264See
BIHBosnia and Herzegovina0.0485134See
PERPeru Arequipa Mestizo8.80.0470168See
THAThailand Northeast0.047066See
BRABrazil Parana Japanese9.00.0469192See
MEXMexico Queretaro Rural0.046543See
MKDMacedonia MBMDR - Macedonian Muslims9.20.046176See
MARMorocco Casablanca0.0460100See
ARGArgentina La Plata9.00.0450100See
HRVCroatia pop 20.0440100See
BRABrazil Rio Grande do Sul Black0.0440248See
MEXMexico Chihuahua Rural0.0439236See
INDIndia Bikaner Raikas8.40.0430143See
PRTPortugal North0.043046See
THAThailand Northeast pop 20.0430400See
BRABrazil Rio Grande do Sul Mixed0.0430324See
BRABrazil REDOME Mato Grosso do Sul0.042395667See
BRABrazil REDOME Maranhao0.042210180See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.042096See
INDIndia Kerala Hindu Ezhava0.042024See
CHNChina Yunnan Province Han pop 20.0420129See
BIHBosnia and Herzegovina pop 28.30.0417120See
BRABrazil REDOME Acre0.0413859See
RUSRussia South Ural Tatar8.10.0410135See
JPNJapan pop 20.0410916See
BRABrazil Parana Mixed race8.10.0400186See
ESPSpain Ibiza0.040088See
RUSRussia Murmansk Saomi Mixed0.040070See
VENVenezuela Caracas Mestizo0.040050See
BRABrazil Parana Afro Brazilian7.80.039077See
BRABrazil REDOME Mato Grosso0.038834649See
BRABrazil Piaui Mixed0.038021943See
TWNTaiwan Chinese immigrants from Middle China0.0380211See
BRABrazil REDOME Rondonia0.037554396See
CHNChina Shandong Province Linqu County7.30.0371139See
ITAItaly North Pavia0.037081See
RUSRussia Chuvash0.037082See
BRABrazil REDOME Piaui0.036246140See
BRABrazil REDOME Alagoas0.036125349See
BRABrazil REDOME Parana0.0358341639See
BRABrazil REDOME Ceara0.0357101217See
BRABrazil REDOME Tocantins0.035420692See
BRABrazil REDOME Paraiba0.035143868See
BRABrazil REDOME Rio Grande do Sul0.0340241329See
BRABrazil REDOME Espirito Santo0.033888485See
BRABrazil REDOME Sergipe0.03387321See
BRABrazil Paraná Caucasian6.70.0335641See
BRABrazil REDOME Sao Paulo0.0333800809See
BRABrazil REDOME Rio Grande do Norte0.033346603See
BRABrazil REDOME Santa Catarina0.0330106673See
JPNJapan Tohoku Region0.0330322See
JPNJapan Aichi6.50.033050See
BRABrazil Parana Caucasian6.70.03302775See
ITAItaly pop 66.00.0326184See
BRABrazil Rio Grande do Norte Mestizo0.032012973See
BRABrazil Sao Paulo Bauru Mixed0.03203542See
SRBSerbia pop 36.00.03141992See
BRABrazil REDOME Goias0.031188574See
INDIndia Kerala Hindu Pulaya0.031016See
JPNJapan Hyogo6.30.031032See
CAFCentral African Republic Mbenzele Pygmy6.00.030436See
BRABrazil REDOME Federal District0.030329549See
RUSRussia Northwest pop 36.00.0300100See
JPNJapan Kyoto and Osaka0.0300165See
CHNChina Yunnan Province Naxi0.0300118See
ROMRomania pop 20.03006936See
BRABrazil South Ribeirao Preto0.0300184See
CHNChina Harbin Korean0.0300201See
BRABrazil Pernambuco Mixed0.0300101See
DEUGermany Essen5.80.0300174See
GRCGreece North0.0300500See
TWNTaiwan Chinese immigrants from South China0.0300172See
ITAItaly Lombardy5.90.0300674See
ROMRomania pop 35.70.02941469See
HRVCroatia pop 35.80.0292120See
MYSMalaysia Sarawak Iban0.029051See
CHNChina Harbin Manchu0.0290172See
BRABrazil Rio Grande do Sul Caucasoid0.02904428See
PHLPhilippines National Capital Region0.029051See
BRABrazil South East Cord Blood0.028911409See
GRCGreece pop35.70.0289246See
GRCGreece pop 70.028811250See
MKDMacedonia MBMDR - Macedonian5.50.02841283See
BRABrazil REDOME Bahia0.028247399See
BRABrazil REDOME Pernambuco0.028292332See
TWNTaiwan Hakka pop 20.0280714See
JPNJapan Hyogo Osaka and Nagano0.0280195See
ESPSpain Majorca and Minorca0.028090See
CHNChina Shanghai0.028026266See
BRABrazil REDOME Rio de Janeiro0.0278139322See
BRABrazil REDOME Minas Gerais0.0270211275See
THAThailand pop 40.027016807See
PRTAzores Terceira Island0.0270130See
ESPSpain North Cabuerniga0.026095See
ESPSpain Arratia Valley Basque0.026083See
TWNTaiwan Minnan pop 20.02607137See
ITAItaly North Pavia pop 25.10.02602416See
CMRCameroon Ewondo0.026038See
GBRUnited Kingdom South West0.0257163See
ALBAlbanian Kosovo0.0250120See
FRAFrance Bordeaux4.90.0250990See
RUSRussia Samara Region0.02502500See
MKDMacedonia pop 40.0250216See
ESPSpain Majorca0.0250407See
ITAItaly Rome5.00.0250100See
ARMArmenia Lori0.0250102See
FRAFrance Grenoble4.90.02461000See
ALBAlbania pop 24.60.0243432See
GBRUnited Kingdom Orkney0.024088See
RUSRussia South Ural Russian4.80.0240207See
BRABrazil Minas Gerais State Mixed4.60.02401000See
TURTurkey pop 50.0240142See
INDIndia Kerala Hindu Nair0.024041See
INDIndia Kerala Adiya0.024021See
RUSRussia Tatars0.0239355See
ITAItaly North Pavia pop 30.0237685See
ESPSpain Catalonia Girona0.023088See
TWNTaiwan Chinese immigrants from North China0.0230152See
FRAFrance Southeast4.60.0230130See
SRBSerbia Vojvodina4.70.0230400See
FRAFrance Rennes pop 44.60.02281000See
RUSRussia Moscow Pop 24.60.02272000See
SVKSlovakia pop 20.02264234See
RUSRussia Northwest4.40.02221011See
ITAItaly Bergamo3.90.0220101See
BRABrazil Parana Cafuzo4.40.0220319See
FRAFrance Grenoble, Nantes and Rennes0.02206094See
CHNChina Jiangsu Province0.022020248See
PRTPortugal Braga0.02201971See
PRTPortugal Viseu0.02202915See
PRTPortugal Portalegre0.02201254See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks4.50.0220112See
FRAFrance Lyon4.40.02194813See
PRTPortugal Castelo Branco0.0210327See
TWNTaiwan Minnan and Hakka0.0210190See
ENGEngland Manchester4.10.02071640See
ENGEngland Newcastle4.00.02022739See
ESPSpain North4.00.0202156See
IRQIraq Arabs4.00.0201149See
ITAItaly East Sicily4.00.020050See
SVNSlovenia pop 33.90.0200130See
FRAFrance Reims0.0200102See
PRTPortugal Beja0.0200699See
RUSRussia Moscow0.02002650See
PRTPortugal Viana do Castelo0.0200706See
BRABrazil Sao Paulo Mixed0.40.0200239See
ENGEngland North West Mixed pop 24.00.0198379See
POLPoland pop 34.00.01972907See
SAUSaudi Arabia pop 43.80.0191499See
FRAFrance Marseille3.80.01901000See
TZATanzania Dodoma Kongwa0.0190212See
PAKPakistan Brahui0.0190104See
USAUSA Caucasian Bethesda3.80.0190307See
MMRMyanmar Shan3.70.018554See
ESPSpain, Castilla y Leon, Northwest,4.10.01831743See
MMRMyanmar Chin3.60.018255See
ITAItaly South Campania Region3.60.01811089See
CUBCuba Mixed pop 20.0180189See
CHNChina Shandong Province3.50.01807418See
USAUSA OPTN Caucasian0.01808525See
IRLIreland South pop 20.017317624See
ENGEngland Leeds3.40.01715024See
PRTPortugal South pop 20.01701021See
PRTPortugal Center pop 20.0170562See
MKDMacedonia pop 30.0170172See
WALWales pop 23.40.017039979See
PRTPortugal Bragança0.0170301See
CHNChina Shaanxi Province Han0.017010000See
PRTPortugal Coimbra0.01705057See
SWESweden pop 43.00.0166966See
ESPSpain Sevilla3.20.0162278See
PRTPortugal Leiria0.01601847See
PRTPortugal Santarem0.01603865See
PRTPortugal Setubal0.01605268See
USAUSA OPTN Asian0.0160261See
ESPSpain Pas Valley0.016088See
GRCGreece Crete0.0160135See
RUSRussia North Ossetian3.10.0157127See
MMRMyanmar Mon3.10.015664See
ENGEngland Liverpool3.10.01561343See
PRTPortugal North pop 20.01551801See
GBRUnited Kingdom North0.0154330See
ENGEngland Sheffield3.00.01514755See
DZAAlgeria pop 23.00.0151106See
SWESweden Uppsala3.00.0151300See
PAKPakistan Baloch0.015066See
LKASri Lanka Colombo Sinhalese0.0150101See
PRTPortugal Aveiro0.01505933See
PRTPortugal Lisbon0.015017420See
ARMArmenia living in USA0.0150233See
PRTPortugal Faro0.01401242See
PRTMadeira pop 30.0140538See
RUSRussia South Ural Bashkir2.70.0140146See
AUSAustralia West Caucasian2.80.0140891See
NORNorway ethnic Norwegians2.70.01364510See
IRQIraq Erbil2.70.0135372See
ARMArmenia Shirak0.013076See
INDIndia Kerala Hindu Namboothiri0.013040See
PRTPortugal Vila Real0.01301167See
KORSouth Korea pop 80.01307096See
USAUSA OPTN African American0.01201510See
AREUnited Arab Emirates pop 22.40.0120373See
PRTPortugal Porto0.01207937See
ARMArmenia Yerevan0.0120445See
ESPSpain North Cantabria0.012083See
ARMArmenia living in Iran0.012085See
GAZGaza Palestinians0.0120165See
MKDMacedonia MBMDR - Albanian2.30.0117128See
MMRMyanmar Kayin2.30.011444See
TURTurkey pop 20.0110228See
ESPSpain Minorca0.011094See
ENGEngland Lancaster2.20.0110545See
PAKPakistan Karachi Parsi0.011091See
PRTPortugal Guarda0.0110797See
PRTPortugal Evora0.0110737See
RUSRussia Northwest pop 22.20.0110346See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.011094See
CZECzech Republic Romani pop 22.20.010946See
MMRMyanmar Bamar2.20.010946See
MMRMyanmar Rakhine2.10.010448See
ARMArmenia living in Karabakh0.0100445See
ARMArmenia Ghegharkunik0.0100242See
RUSRussia Transbaikal Territory Buryats2.00.0100150See
INDIndia Bikaner Non-Raikas1.90.0100127See
MYSMalaysia Sarawak Bidayuh0.010050See
FRAFrance Rennes pop 30.0100200See
BGDBangladesh Dhaka Bangalee0.0100141See
VNMVietnam Hanoi0.010050See
ESPSpain Gipuzkoa Basque0.0100100See
MNGMongolia Khalkha pop 20.0100202See
ITAItaly Sardinia pop30.0100100See
SCOScotland Orkney2.00.010099See
PAKPakistan Mixed Sindhi0.0100101See
MNGMongolia Khalkha0.0100200See
TTOTrinidad South Asian0.010087See
MYSMalaysia pop 20.009062See
ISRIsrael Moroccan Jews0.0090113See
MYSMalaysia Sabah Kadazan0.009057See
MARMorocco pop 20.0090110See
INDIndia North pop 30.0080587See
SAUSaudi Arabia pop 20.0080383See
ISRIsrael Jews pop 21.60.008023000See
CHNChina Wuhan1.70.0080121See
KORSouth Korea pop 10.0080324See
ESPSpain Murcia0.0080173See
GBRUnited Kingdom Central0.0075135See
ARMArmenia living in Lebanon0.0070368See
IRNIran pop 40.0070855See
TTOTrinidad African0.007067See
MYSMalaysia pop 30.00701445See
IRNIran Royan Cord Blood Bank1.50.007015600See
CZECzech Republic Kurd1.40.006874See
PRTMadeira pop 20.0060173See
MNGMongolia Tarialan Khoton0.006085See
SDNSudan Khartoum0.005198See
CHLChile Santiago Mixed1.00.005070See
FRAFrance Corsica Island0.0050100See
ESPSpain Majorcans Jews0.0050103See
PAKPakistan Burusho0.005092See
INDIndia sub-Himalayan West Bengal Kami0.60.0032158See
GBRUnited Kingdom East0.0031163See
INDIndia North Gujarat0.60.0030338See
CMRCameroon Bamileke 20.000035See
MYSMalaysia Negeri Sembilan Minangkabau0.000034See
MYSMalaysia Perak Rawa0.000023See
GBRUnited Kingdom pop 20.0000101See
PAKPakistan Kalash0.000069See
PAKPakistan Mixed Pathan0.0000100See
MNGMongolia Oold0.0000104See
MNGMongolia Tsaatan0.0000144See
ITAItaly North pop 30.00.000097See
USAUSA African American Bethesda0.00.0000187See
INDIndia Kerala Syrian Christian0.000031See
INDIndia Kerala Paniya0.000010See
INDIndia Kerala Malapandaram0.000010See
INDIndia Kerala Kurichiya0.000010See
INDIndia Kerala Kanikkar0.000022See
INDIndia Kerala Kattunaikka0.000017See
INDIndia Kerala Kuruma0.000015See
INDIndia Kerala Malabar Muslim0.000034See
MNGMongolia Ulaanbaatar Khalkha0.000041See
ISRIsrael Ashkenazi Jews pop 20.0000132See
CHNChina North Han0.0000105See
BFABurkina Faso Fulani0.000049See
BFABurkina Faso Rimaibe0.000047See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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