Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 339 time(s) and present in 288 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
PERPeru Lamas City Lama0.247083See
ARGArgentina Chiriguano35.80.217054See
RUSRussia Nenet Mixed0.157055See
BOLBolivia La Paz Aymaras0.149087See
MEXMexico Guanajuato, Guanajuato city0.136422See
TWNTaiwan Aborigine0.1210111See
BOLBolivia Quechua0.115969See
RUSRussia Sakhalin Island Nivkhi0.113053See
ARGArgentina Salta Wichi pop 215.80.105019See
CHLChile Easter Island0.095021See
INDIndia North pop 30.0940587See
MEXMexico Colima, Colima city0.090261See
PERPeru Arequipa Mestizo14.90.0820168See
MEXMexico Queretaro, Queretaro city0.077845See
RUSRussia South Ural Bashkir13.70.0750146See
MNGMongolia Ulaanbaatar Khalkha0.073041See
ARMArmenia living in Iran0.071085See
MEXMexico Nayarit Rural0.070364See
MEXMexico Coahuila, Saltillo0.068572See
SDNSudan South Nuba13.00.067246See
MEXMexico Nuevo Leon, Monterrey city0.0664226See
ECUEcuador Amazonia Mixed Ancestry0.064139See
MEXMexico Jalisco, Tlaquepaque0.064139See
RUSRussia Transbaikal Territory Buryats13.00.0630150See
MEXMexico Coahuila Rural0.0619216See
MEXMexico Tlaxcala Rural0.0608830See
MEXMexico Baja Californa, Mexicali0.0600100See
MEXMexico Baja California, Tijuana0.060025See
CHNChina Harbin Manchu0.0580172See
MNGMongolia Khalkha pop 20.0570202See
MEXMexico Mexico City East0.056379See
MEXMexico Chihuahua, Ciudad Juarez0.0556106See
MEXMexico Chiapas Rural0.0537121See
MEXMexico Mexico City North0.0525751See
MEXMexico Quintana Roo, Cancun0.052148See
ECUEcuador Andes Mixed Ancestry0.0516824See
MEXMexico Guanajuato, Leon0.051378See
MEXMexico San Luis Potosi, San Luis Potosi city0.050030See
MEXMexico Jalisco, Tlajomulco0.050030See
MEXMexico Sinaloa Capomos Mayo Yoremes0.050060See
CHNChina Yunnan Province Naxi0.0490118See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks9.80.0490112See
MEXMexico Michoacan Rural0.0487348See
MEXMexico Zacatecas Rural0.0483266See
ECUEcuador Mixed Ancestry0.04691173See
MEXMexico Baja California, La Paz0.046775See
MEXMexico Nayarit, Tepic0.046497See
MEXMexico Durango, Durango city0.0452153See
CHNChina Harbin Korean0.0450201See
MEXMexico Mayan Pop 30.045066See
MEXMexico Mexico City West0.044833See
MEXMexico Tlaxcala, Tlaxcala city0.0442181See
MEXMexico Tamaulipas Rural0.0437125See
MEXMexico Tabasco, Villahermosa0.042782See
MEXMexico Nuevo Leon Rural0.0420439See
JPNJapan Kyoto and Osaka0.0420165See
MEXMexico Veracruz, Xalapa0.0401187See
MEXMexico Baja California Rural0.040050See
MNGMongolia Oold0.0390104See
MEXMexico Puebla, Puebla city0.03761994See
KORSouth Korea pop 80.03707096See
MEXMexico Hidalgo, Pachuca0.036641See
MEXMexico Michoacan, Morelia0.0364150See
MEXMexico Oaxaca, Oaxaca city0.0364151See
MEXMexico Jalisco, Guadalajara city0.03561189See
MEXMexico Puebla Rural0.0354833See
MEXMexico Mexico City Mestizo pop 30.0350256See
MNGMongolia Khalkha0.0350200See
MNGMongolia Tarialan Khoton0.035085See
CHNChina Shandong Province6.70.03407418See
MEXMexico Chihuahua Rural0.0335236See
JPNJapan Aichi6.50.033050See
CHNChina Shandong Province Linqu County6.50.0330139See
MEXMexico Mexico City Center0.0325152See
MEXMexico Veracruz, Veracruz city0.0320171See
KORSouth Korea pop 10.0310324See
MEXMexico Hidalgo Rural0.030981See
MEXMexico Guanajuato Rural0.0307162See
MEXMexico Veracruz Rural0.0305539See
MEXMexico Sonora Rural0.0305197See
MEXMexico Coahuila, Torreon0.0300396See
MYSMalaysia Negeri Sembilan Minangkabau0.030034See
MYSMalaysia Sarawak Bidayuh0.030050See
JPNJapan Tohoku Region0.0300322See
BRABrazil Parana Oriental6.10.030033See
USAUSA OPTN Asian0.0300261See
MEXMexico Zacatecas, Zacatecas city0.029884See
MEXMexico Mexico City Metropolitan Area Rural0.0296150See
MEXMexico Chihuahua Chihuahua City0.0294119See
MEXMexico Jalisco Rural0.0290585See
PHLPhilippines National Capital Region0.029051See
MEXMexico Mexico City Mestizo0.0290121See
CHNChina Shaanxi Province Han0.029010000See
MEXMexico Mexico City South0.028852See
MEXMexico Zacatecas, Fresnillo0.0286103See
INDIndia sub-Himalayan West Bengal Kami5.70.0285158See
JPNJapan pop 20.0270916See
MEXMexico Sinaloa Mestizo0.027056See
USAUSA OPTN Hispanic0.02601580See
ECUEcuador Coast Mixed Ancestry0.0252238See
CHNChina Wuhan5.00.0250121See
MEXMexico Veracruz, Orizaba0.025060See
BRABrazil Para Cord Blood Unit4.80.0250841See
JPNJapan pop 114.80.024362See
MEXMexico Sinaloa, Culiacán0.0243103See
MEXMexico Guerrero state0.0243144See
MEXMexico Oaxaca Rural0.0236485See
MEXMexico Queretaro Rural0.023343See
MEXMexico San Luis Potosi Rural0.023087See
MEXMexico Tamaulipas, Ciudad Victoria0.021723See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.021094See
MNGMongolia Tsaatan0.0210144See
CHNChina Jiangsu Province0.021020248See
TWNTaiwan Chinese immigrants from South China0.0210172See
TWNTaiwan Chinese immigrants from North China0.0210152See
MEXMexico Yucatan, Merida0.0205192See
CHNChina Guangdong Province4.00.0202403See
BRABrazil Belem Mixed4.00.0200100See
BRABrazil Pernambuco Mixed0.0200101See
MEXMexico Puebla Mestizo0.020099See
BRABrazil REDOME Amazonas0.019724129See
MEXMexico Sinaloa Rural0.0191183See
CHNChina Shanghai0.019026266See
MEXMexico Chiapas, Tuxtla Gutierrez0.018952See
BRABrazil Parana Japanese4.00.0183192See
GEOGeorgia Kurds0.018030See
MEXMexico Veracruz, Coatzacoalcos0.017955See
MEXMexico Veracruz, Cordoba0.017956See
MEXMexico Morelos Rural0.016730See
BRABrazil REDOME Para0.016472637See
BRABrazil REDOME Amapa0.016217864See
MEXMexico Aguascalientes state0.015895See
MMRMyanmar Mon3.10.015664See
CHLChile Santiago0.0152920See
BRABrazil REDOME Acre0.0151859See
JPNJapan Hyogo Osaka and Nagano0.0150195See
PAKPakistan Mixed Sindhi0.0150101See
MEXMexico Mestizo pop 40.0149269See
BRABrazil Para State3.10.01485000See
MEXMexico Campeche, Campeche city0.014734See
MEXMexico Tapachula, Chiapas Mestizo Population2.80.014072See
BRABrazil Parana Cafuzo2.80.0140319See
TWNTaiwan Chinese immigrants from Middle China0.0140211See
BRABrazil REDOME Roraima0.01374140See
BRABrazil Parana Afro Brazilian2.60.013077See
ARGArgentina Corrientes2.60.0130155See
ARGArgentina Cuyo Region2.60.0130420See
TWNTaiwan Minnan and Hakka0.0130190See
BRABrazil REDOME Mato Grosso do Sul0.012895667See
MEXMexico Durango Rural0.0122326See
MEXMexico Morelos, Cuernavaca0.012282See
BRABrazil Rio Grande do Sul Mixed0.0120324See
TWNTaiwan Minnan pop 20.01207137See
RUSRussia Chuvash0.012082See
MEXMexico Jalisco, Zapopan0.0119168See
MEXMexico Colima Rural0.011443See
MEXMexico Veracruz, Poza Rica0.011145See
BRABrazil REDOME Piaui0.011146140See
BRABrazil Piaui Mixed0.011021943See
BRABrazil Parana Mixed race2.10.0110186See
CHNChina Yunnan Province Han pop 20.0110129See
RUSRussia South Ural Tatar2.20.0110135See
CZECzech Republic Romani pop 22.20.010946See
BRABrazil REDOME Maranhao0.010710180See
MEXMexico Campeche Rural0.010647See
MYSMalaysia Sarawak Iban0.010051See
PAKPakistan Burusho0.010092See
RUSRussia Murmansk Saomi Mixed0.010070See
BRABrazil Rio Grande do Sul Black0.0100248See
MEXMexico Quintana Roo Rural0.010050See
VENVenezuela Caracas Mestizo0.010050See
BRABrazil REDOME Mato Grosso0.009834649See
BRABrazil REDOME Alagoas0.009825349See
BRABrazil REDOME Ceara0.0097101217See
MEXMexico San Vicente Tancuayalab Teenek/Huastecos0.009453See
MMRMyanmar Shan1.90.009354See
MMRMyanmar Chin1.80.009155See
MEXMexico Huasteca Region Teenek0.009055See
BRABrazil Rio Grande do Norte Mestizo0.009012973See
BRABrazil REDOME Rio Grande do Norte0.009046603See
ARGArgentina La Plata2.00.0090100See
THAThailand pop 40.009016807See
BRABrazil REDOME Tocantins0.008820692See
INDIndia North Gujarat1.80.0089338See
BRABrazil REDOME Paraiba0.008543868See
BRABrazil REDOME Pernambuco0.008492332See
BRABrazil REDOME Parana0.0080341639See
COLColombia Barranquilla0.0080188See
BRABrazil REDOME Rondonia0.007954396See
MMRMyanmar Kachin1.60.007963See
MEXMexico Yucatan Rural0.0075132See
MEXMexico Michoacan Tarasco1.50.0070130See
BRABrazil REDOME Rio Grande do Sul0.0070241329See
MEXMexico Tabasco Rural0.0070142See
TWNTaiwan Hakka pop 20.0070714See
BRABrazil REDOME Federal District0.006629549See
BRABrazil REDOME Sergipe0.00657321See
BRABrazil REDOME Goias0.006388574See
BRABrazil Curitiba-Parana Mixed0.0062264See
BRABrazil Rio Grande do Sul Caucasoid0.00604428See
ESPSpain Andalusia0.006099See
MYSMalaysia pop 30.00601445See
BRABrazil South East Cord Blood0.005811409See
BRABrazil REDOME Sao Paulo0.0058800809See
RUSRussia Tatars0.0056355See
BRABrazil REDOME Espirito Santo0.005288485See
BRABrazil REDOME Santa Catarina0.0051106673See
MEXMexico Sonora, Hermosillo0.005199See
BRABrazil South Ribeirao Preto0.0050184See
BRABrazil Sao Paulo Bauru Mixed0.00503542See
ARGArgentina Buenos Aires1.10.0050466See
ARGArgentina Buenos Aires pop 21.10.00501216See
BRABrazil Parana Caucasian1.00.00502775See
BRABrazil Sao Paulo Mixed0.10.0050239See
AUSAustralia West Caucasian1.00.0050891See
LKASri Lanka Colombo Sinhalese0.0050101See
RUSRussia Moscow0.00502650See
RUSRussia South Ural Russian1.00.0050207See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.005096See
BRABrazil REDOME Rio de Janeiro0.0049139322See
BRABrazil REDOME Bahia0.004747399See
BRABrazil REDOME Minas Gerais0.0043211275See
HRVCroatia pop 30.80.0042120See
MYSMalaysia pop 20.004062See
TURTurkey pop 50.0040142See
RUSRussia North Ossetian0.80.0039127See
RUSRussia Moscow Pop 20.80.00372000See
ESPSpain Sevilla0.70.0036278See
MEXMexico Sonora, Ciudad Obregón0.0035143See
IRQIraq Arabs0.70.0034149See
BRABrazil Paraná Caucasian0.60.0031641See
BRABrazil Minas Gerais State Mixed0.50.00301000See
ISRIsrael Jews pop 20.60.003023000See
DEUGermany Essen0.60.0030174See
PRTPortugal Beja0.0030699See
PRTMadeira pop 20.0030173See
RUSRussia Samara Region0.00302500See
SVKSlovakia pop 20.00294234See
PRTPortugal North pop 20.00291801See
PRTPortugal Viseu0.00202915See
NORNorway pop 20.0020576See
IRNIran Royan Cord Blood Bank0.30.002015600See
ARMArmenia living in USA0.0020233See
KURIraq Kurdistan Region0.50.0020209See
IRNIran pop 40.0018855See
ROMRomania pop 30.30.00171469See
SWESweden pop 40.30.0016966See
ITAItaly North Pavia pop 30.0016685See
FRAFrance Bordeaux0.30.0016990See
NORNorway ethnic Norwegians0.30.00144510See
ENGEngland North West Mixed pop 20.30.0013379See
IRQIraq Erbil0.30.0013372See
ALBAlbania pop 20.20.0012432See
ARMArmenia living in Lebanon0.0010368See
ITAItaly South Campania Region0.20.00101089See
ITAItaly North Pavia pop 20.10.00102416See
ESPSpain Majorca0.0010407See
GRCGreece North0.0010500See
PRTPortugal Aveiro0.00105933See
PRTPortugal Braga0.00101971See
PRTPortugal Viana do Castelo0.0010706See
PRTPortugal Lisbon0.001017420See
PRTPortugal Porto0.00107937See
PRTPortugal Evora0.0010737See
PRTPortugal Faro0.00101242See
SRBSerbia pop 30.20.00101992See
SRBSerbia Vojvodina0.20.0010400See
SAUSaudi Arabia pop 20.0010383See
USAUSA OPTN Caucasian0.00108525See
WALWales pop 20.10.001039979See
USAUSA OPTN African American0.00101510See
POLPoland pop 30.10.00072907See
GRCGreece pop 70.000611250See
FRAFrance Rennes pop 40.10.00051000See
FRAFrance Marseille0.10.00051000See
ENGEngland Manchester0.10.00051640See
ESPSpain, Castilla y Leon, Northwest,0.20.00041743See
FRAFrance Lyon0.10.00044813See
MKDMacedonia MBMDR - Macedonian0.10.00041283See
IRLIreland South pop 20.000117624See
ITAItaly Rome0.00.0000100See
ITAItaly North pop 30.00.000097See
ITAItaly Bergamo0.00.0000101See
MARMorocco Casablanca0.0000100See
MARMorocco pop 20.0000110See
MEXMexico Nahuas0.000072See
FRAFrance Southeast0.00.0000130See
FRAFrance Grenoble, Nantes and Rennes0.00006094See
HRVCroatia pop 20.0000100See
CHNChina North Han0.0000105See
ESPSpain Minorca0.000094See
ESPSpain Ibiza0.000088See
ESPSpain Majorcans Jews0.0000103See
ESPSpain Murcia0.0000173See
ENGEngland Leeds0.00.00005024See
BIHBosnia and Herzegovina0.0000134See
MKDMacedonia pop 40.0000216See
PAKPakistan Brahui0.0000104See
NORNorway Sami0.0000200See
MYSMalaysia Perak Rawa0.000023See
PRTPortugal North0.000046See
PRTPortugal South pop 20.00001021See
PAKPakistan Kalash0.000069See
PAKPakistan Mixed Pathan0.0000100See
PAKPakistan Karachi Parsi0.000091See
PRTPortugal Vila Real0.00001167See
PRTMadeira pop 30.0000538See
PRTPortugal Guarda0.0000797See
RUSRussia Northwest0.00.00001011See
RUSRussia Arkhangelsk Pomor0.000063See
PRTPortugal Santarem0.00003865See
PRTPortugal Setubal0.00005268See
PRTPortugal Bragança0.0000301See
PRTPortugal Castelo Branco0.0000327See
PRTPortugal Coimbra0.00005057See
PRTPortugal Portalegre0.00001254See
PRTPortugal Leiria0.00001847See
MEXMexico Jalisco, Tonala0.000035See
VNMVietnam Hanoi0.000050See
ZAFSouth Africa Natal Zulu0.00.0000100See
VENVenezuela Colonia Tovar0.000086See
SCOScotland Orkney0.00.000099See
RUSRussia Northwest pop 20.00.0000346See
RUSRussia Northwest pop 30.00.0000100See
TZATanzania Dodoma Kongwa0.0000212See
USAUSA Caucasian Bethesda0.00.0000307See
USAUSA African American Bethesda0.00.0000187See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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