Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 202 time(s) and present in 53 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
CMRCameroon Podokwo0.023043See
TUNTunisia Ghannouch0.018082See
CMRCameroon Uldeme0.014035See
USAUSA African American Bethesda2.10.0110187See
USAUSA OPTN African American0.00301510See
MEXMexico Jalisco, Zapopan0.0030168See
BRABrazil Parana Cafuzo0.30.0020319See
MEXMexico Zacatecas Rural0.0019266See
MEXMexico Mestizo pop 40.0019269See
BRABrazil REDOME Maranhao0.001310180See
ALBAlbania pop 20.20.0012432See
BRABrazil Para State0.10.00105000See
BRABrazil REDOME Pernambuco0.001092332See
BRABrazil Minas Gerais State Mixed0.10.00101000See
BRABrazil Rio Grande do Norte Mestizo0.001012973See
BRABrazil Piaui Mixed0.001021943See
PRTPortugal Beja0.0010699See
SAUSaudi Arabia pop 40.20.0010499See
WALWales pop 20.00.001039979See
BRABrazil REDOME Amapa0.000917864See
BRABrazil REDOME Bahia0.000947399See
BRABrazil REDOME Para0.000972637See
BRABrazil REDOME Rio de Janeiro0.0008139322See
BRABrazil Paraná Caucasian0.20.0008641See
BRABrazil REDOME Mato Grosso0.000734649See
BRABrazil REDOME Paraiba0.000743868See
BRABrazil REDOME Amazonas0.000724129See
BRABrazil REDOME Espirito Santo0.000688485See
BRABrazil REDOME Ceara0.0006101217See
BRABrazil REDOME Acre0.0006859See
BRABrazil REDOME Piaui0.000646140See
BRABrazil REDOME Rondonia0.000654396See
BRABrazil REDOME Sergipe0.00067321See
BRABrazil South East Cord Blood0.000611409See
BRABrazil REDOME Minas Gerais0.0005211275See
BRABrazil REDOME Federal District0.000529549See
BRABrazil REDOME Alagoas0.000425349See
BRABrazil REDOME Goias0.000488574See
BRABrazil REDOME Sao Paulo0.0004800809See
BRABrazil REDOME Tocantins0.000420692See
BRABrazil REDOME Rio Grande do Norte0.000446603See
BRABrazil REDOME Parana0.0003341639See
BRABrazil REDOME Santa Catarina0.0003106673See
BRABrazil REDOME Mato Grosso do Sul0.000395667See
MEXMexico Puebla, Puebla city0.00031994See
BRABrazil REDOME Rio Grande do Sul0.0001241329See
BRABrazil REDOME Roraima0.00014140See
BRABrazil Rio Grande do Sul Caucasoid0.00014428See
BRABrazil Sao Paulo Bauru Mixed0.00003542See
BRABrazil Parana Mixed race0.00.0000186See
BRABrazil Parana Afro Brazilian0.00.000077See
BRABrazil Parana Oriental0.00.000033See
AREUnited Arab Emirates pop 20.00.0000373See
ARGArgentina La Plata0.00.0000100See
ARGArgentina Chiriguano0.00.000054See
ARGArgentina Salta Wichi pop 20.00.000019See
ARGArgentina Buenos Aires pop 20.00.00001216See
ARGArgentina Cuyo Region0.00.0000420See
ARGArgentina Corrientes0.00.0000155See
AUSAustralia West Caucasian0.00.0000891See
BIHBosnia and Herzegovina0.0000134See
BRABrazil Sao Paulo Mixed0.00.0000239See
BRABrazil Parana Caucasian0.10.00002775See
MEXMexico Quintana Roo, Cancun0.000048See
MEXMexico Mexico City West0.000033See
MEXMexico Campeche Rural0.000047See
MEXMexico Yucatan Rural0.0000132See
MEXMexico Quintana Roo Rural0.000050See
MEXMexico Baja California, Tijuana0.000025See
MEXMexico Tlaxcala Rural0.0000830See
MEXMexico Puebla Rural0.0000833See
MEXMexico Oaxaca Rural0.0000485See
MEXMexico Morelos Rural0.000030See
MEXMexico Tabasco Rural0.0000142See
MEXMexico Chiapas Rural0.0000121See
MEXMexico Queretaro Rural0.000043See
MEXMexico Tamaulipas Rural0.0000125See
MEXMexico San Luis Potosi Rural0.000087See
MEXMexico Veracruz Rural0.0000539See
MEXMexico Hidalgo Rural0.000081See
MEXMexico Mexico City Metropolitan Area Rural0.0000150See
MEXMexico Nayarit Rural0.000064See
MEXMexico Jalisco Rural0.0000585See
MEXMexico Michoacan Rural0.0000348See
MEXMexico Guanajuato Rural0.0000162See
MEXMexico Colima Rural0.000043See
MEXMexico Nuevo Leon Rural0.0000439See
MEXMexico Sonora Rural0.0000197See
MEXMexico Sinaloa Rural0.0000183See
MEXMexico Chihuahua Rural0.0000236See
MEXMexico Durango Rural0.0000326See
MEXMexico Coahuila Rural0.0000216See
ECUEcuador Coast Mixed Ancestry0.0000238See
ECUEcuador Amazonia Mixed Ancestry0.000039See
ECUEcuador Andes Mixed Ancestry0.0000824See
ECUEcuador Mixed Ancestry0.00001173See
ESPSpain Majorca0.0000407See
ESPSpain Minorca0.000094See
ESPSpain Ibiza0.000088See
ESPSpain Majorcans Jews0.0000103See
ESPSpain Murcia0.0000173See
ESPSpain, Castilla y Leon, Northwest,0.00.00001743See
FRAFrance Rennes pop 30.0000200See
HRVCroatia pop 20.0000100See
IRNIran Royan Cord Blood Bank0.00.000015600See
ITAItaly Rome0.00.0000100See
ITAItaly North pop 30.00.000097See
MARMorocco pop 20.0000110See
MEXMexico Mexico City Mestizo0.0000121See
MEXMexico Puebla Mestizo0.000099See
MEXMexico Sinaloa Mestizo0.000056See
MEXMexico Tlaxcala, Tlaxcala city0.0000181See
MEXMexico Mexico City South0.000052See
MEXMexico Mexico City North0.0000751See
MEXMexico Mexico City East0.000079See
MEXMexico Yucatan, Merida0.0000192See
MEXMexico Campeche, Campeche city0.000034See
MEXMexico Chiapas, Tuxtla Gutierrez0.000052See
MEXMexico Tabasco, Villahermosa0.000082See
MEXMexico Morelos, Cuernavaca0.000082See
MEXMexico Oaxaca, Oaxaca city0.0000151See
MKDMacedonia pop 40.0000216See
CHNChina North Han0.0000105See
CMRCameroon Ewondo0.000038See
CMRCameroon Bamileke 20.000035See
PRTPortugal Braga0.00001971See
PRTPortugal Bragança0.0000301See
PRTPortugal Castelo Branco0.0000327See
PRTPortugal Viseu0.00002915See
PRTMadeira pop 30.0000538See
PRTPortugal Portalegre0.00001254See
PRTPortugal Porto0.00007937See
PRTPortugal Santarem0.00003865See
PRTPortugal Setubal0.00005268See
PRTPortugal Viana do Castelo0.0000706See
PRTPortugal Vila Real0.00001167See
PRTPortugal Coimbra0.00005057See
PRTPortugal Evora0.0000737See
PRTPortugal Faro0.00001242See
PRTPortugal Guarda0.0000797See
PRTPortugal Leiria0.00001847See
PRTPortugal Lisbon0.000017420See
RUSRussia Nenet Mixed0.000055See
RUSRussia Arkhangelsk Pomor0.000063See
RUSRussia Murmansk Saomi Mixed0.000070See
RUSRussia South Ural Russian0.00.0000207See
RUSRussia South Ural Bashkir0.00.0000146See
RUSRussia South Ural Tatar0.00.0000135See
RUSRussia Northwest pop 30.00.0000100See
MEXMexico Veracruz, Orizaba0.000060See
MEXMexico Veracruz, Coatzacoalcos0.000055See
MEXMexico San Luis Potosi, San Luis Potosi city0.000030See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
MEXMexico Queretaro, Queretaro city0.000045See
MEXMexico Aguascalientes state0.000095See
MEXMexico Mexico City Center0.0000152See
MEXMexico Hidalgo, Pachuca0.000041See
MEXMexico Veracruz, Xalapa0.0000187See
MEXMexico Veracruz, Veracruz city0.0000171See
MEXMexico Veracruz, Poza Rica0.000045See
MEXMexico Veracruz, Cordoba0.000056See
MEXMexico Guerrero state0.0000144See
MEXMexico Sinaloa, Culiacán0.0000103See
MEXMexico Sonora, Hermosillo0.000099See
MEXMexico Sonora, Ciudad Obregón0.0000143See
MEXMexico Baja California, La Paz0.000075See
MEXMexico Baja Californa, Mexicali0.0000100See
MEXMexico Baja California Rural0.000050See
MEXMexico Zacatecas, Zacatecas city0.000084See
MEXMexico Coahuila, Torreon0.0000396See
MEXMexico Coahuila, Saltillo0.000072See
MEXMexico Durango, Durango city0.0000153See
MEXMexico Chihuahua, Ciudad Juarez0.0000106See
MEXMexico Chihuahua Chihuahua City0.0000119See
MEXMexico Jalisco, Tonala0.000035See
MEXMexico Jalisco, Tlaquepaque0.000039See
MEXMexico Jalisco, Tlajomulco0.000030See
MEXMexico Jalisco, Guadalajara city0.00001189See
MEXMexico Nayarit, Tepic0.000097See
MEXMexico Zacatecas, Fresnillo0.0000103See
MEXMexico Nuevo Leon, Monterrey city0.0000226See
MEXMexico Colima, Colima city0.000061See
MEXMexico Guanajuato, Leon0.000078See
MEXMexico Guanajuato, Guanajuato city0.000022See
MEXMexico Michoacan, Morelia0.0000150See
USAUSA OPTN Hispanic0.00001580See
USAUSA OPTN Caucasian0.00008525See
USAUSA OPTN Asian0.0000261See
MYSMalaysia pop 20.000062See
PRTPortugal South pop 20.00001021See
PRTPortugal Aveiro0.00005933See
TZATanzania Dodoma Kongwa0.0000212See
USAUSA South Texas Hispanic0.0000194See
USAUSA Caucasian Bethesda0.00.0000307See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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