Allele Frequencies in World Populations

HLA Database Rare Alleles Rare Alleles Detector (RAD)

About RAD

The Rare Alleles Detector (RAD) has been designed to assist users in the detection of potential rare alleles found in your laboratory. The RAD tool provides a summary of those alleles that are considered to be very rare (never seen excluding the initial confirmation in IMGT/HLA), rare (seen 1, 2 and 3 times, excluding IMGT/HLA) and frequent (seen more than 3 times, excluding IMGT/HLA).

How to

1. Enter your alleles inside the box, i.e. by "copy and paste" your data from your spreasheet or any electronic source. The data (alleles) must be in this format.

    - For multiple loci, please use tabs, spaces, commas[,] or semicolons[;] to separate your alleles.

    - If you have your data in a text file (using our format), use the "Browse" and "Load from file" options. This will fill the text box.

2. Once you have filled the text box click on "Analyse" to start the process.

3. Use the "Reset Values" button to start a new analysis.

Tip: Click on "Load example" to see an example of the analysis.



Colour code

 Very Rare
 Invalid name
 Alleles not considered due to low resolution are shown in blank

Individual IDA(1)A(2)B(1)B(2)C(1)C(2)DPA1(1)DPA1(2)DPB1(1)DPB1(2)DQA1(1)DQA1(2)DQB1(1)DQB1(2)DRB1(1)DRB1(2)
00000230:04:0166:01:0141:01:0149:01:0116:02:0107:01:0101:03:01 02:01:02 05:01:01 02:01:01 03:01:01 
00000324:02:0124:03:0135:01:0138:01:0104:01:0112:03:0101:03:01 04:01:01 01:03:0103:01:0103:02:0106:03:0113:01:0104:02:01
00000602:01:0103:02:0115:17:0118:01:0107:01:0107:01:0201:03:01 02:01:0204:01:0105:01:0105:05:0102:01:0103:01:0103:01:0111:03:01
00000702:05:0126:01:0114:02:0158:01:0107:1808:02:0101:03:01 02:01:0204:01:0101:01:0203:03:0102:02:0105:01:0101:03:0104:05:01
00000801:01:01 08:01:0158:01:0103:02:0207:02:0101:03:01 04:01:01 03:01:0105:01:0102:01:0103:02:0103:01:0104:02:01
00000901:01:0130:04:0135:01:0141:01:0104:01:0116:02:0101:03:01 02:01:0204:01:0105:01:0105:05:0102:01:0103:01:0103:01:0111:103:01
00001011:01:0133:01:0114:02:0140:02:0108:02:0112:03:01    01:01:0205:05:0103:01:0105:01:0101:02:0111:01:01
00001201:01:0103:02:0157:01:0108:01:0106:02:0107:02:0101:03:01 04:01:0104:02:0103:01:0105:05:0103:02:0103:01:0104:03:0103:01:01
12 individual(s) typed.

Summary of results

 Very Rare (n=0) [ ]
 Rare (n=6) [ A*66:01:01 (1) B*41:01:01 (2) C*03:02:02 (1) DQA1*01:01:02 (3) DQA1*01:05:01 (1) DQA1*03:03:01 (1) ]
 Frequent (n=52)

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

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