Allele Frequencies in World Populations
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The Allele Frequency Net Database

Does any of this interest you?

Latest developments in AFND:
o New definition of geographical regions
o Data quality guidelines in AFND
o HLA Epitope Frequency section
o HLA and Adverse Drug Reactions section
o KIR and Disease Associations section


Allele Frequencies in Worldwide Populations

The Allele Frequency Net Database (AFND) provides a central source, freely available to all, for the storage of allele frequencies from different polymorphic areas in the Human Genome. Users can contribute the results of their work into one common database and can perform database searches on information already available.

We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data.

Please cite this website using our last publication: Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 28, D784-8. [Full Text]

You should also cite the original publication report of the data in your references.

Database information

Polymorphic Region Population Studies Gene/Allele Data Haplotype Data Genotype Data
HLA12101195584 -
KIR255254 - 171
Cytokine124124 - -
MIC636322 -
Totals 1,652 1,636 606 171

The current number of frequencies stored in our database is: 138,052 (HLA), 6,149 (KIR), 4,226 (Cytokine) and 854 (MIC) from 10,543,111 individuals.

We have updated the website with the new IMGT/HLA nomenclature guidelines.
IMGT/HLA last Update: 3.37.0, 10 July, 2019. | IPD-KIR last Update: 2.6.0, 17 February, 2015.

AFND is part of EUROSTAM (an FP7-HEALTH collaborative project) to facilitate transplantation of highly sensitized patients.




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