Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 408 time(s) and present in 363 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
VENVenezuela Zulia San Jose de Heras Mixed0.225020See
INDIndia Kerala Malapandaram0.200010See
MNGMongolia Khalkha pop 20.0980202See
LKASri Lanka Colombo Sinhalese0.0940101See
INDIndia Kerala Malabar Muslim0.088034See
GBRUnited Kingdom Orkney0.065988See
CZECzech Republic Gypsy pop 210.90.065246See
INDIndia Kerala Syrian Christian0.065031See
MMRMyanmar Mon10.90.062564See
BRABrazil Sao Paulo Mixed12.00.0620239See
INDIndia North Gujarat12.10.0607338See
TTOTrinidad South Asian0.060087See
GBRUnited Kingdom pop 20.0590101See
BRABrazil Parana Afro Brazilian11.70.058077See
USAUSA OPTN African American0.05501510See
ESPSpain Majorcans Jews0.0550103See
ENGEngland London Ashkenazi Jews0.0540500See
ISRIsrael Ashkenazi Jews pop 20.0530132See
DZAAlgeria pop 210.00.0513106See
NORNorway Sami0.0510200See
GBRUnited Kingdom North0.0507330See
INDIndia Kerala Kurichiya0.050010See
TTOTrinidad African0.050067See
SCOScotland Orkney9.80.049099See
ENGEngland North West Mixed pop 29.80.0488379See
ESPSpain North Cantabria0.048083See
CHNChina Harbin Manchu0.0470172See
BFABurkina Faso Mossi0.047053See
MARMorocco Casablanca0.0460100See
IRLIreland South pop 20.045417624See
GBRUnited Kingdom South West0.0450163See
RUSRussia Northwest pop 39.00.0450100See
ESPSpain Gipuzkoa Basque0.0450100See
CHNChina Harbin Korean0.0450201See
ENGEngland Newcastle8.70.04442739See
FRAFrance Reims0.0440102See
ENGEngland Sheffield8.60.04394755See
MEXMexico Tamaulipas, Ciudad Victoria0.043523See
PRTAzores Terceira Island0.0430130See
WALWales pop 28.20.042039979See
GBRUnited Kingdom Central0.0414135See
GHAGhana Accre Asutuare Akan0.0410429See
ENGEngland Liverpool7.90.04031343See
ENGEngland Leeds7.90.04035024See
BRABrazil Pernambuco Mixed0.0400101See
ESPSpain Murcia0.0400173See
INDIndia North pop 30.0400587See
ENGEngland Manchester7.70.03921640See
CUBCuba Mixed0.039078See
BRABrazil Rio Grande do Sul Black0.0380248See
GBRUnited Kingdom renal patients7.30.03807007See
MEXMexico Chiapas, Tuxtla Gutierrez0.037752See
POLPoland pop 37.50.03762907See
BRABrazil Minas Gerais State Mixed7.20.03701000See
USAUSA OPTN Caucasian0.03608525See
ESPSpain Andalusia0.036099See
PRTPortugal Vila Real0.03601167See
PRTPortugal Viseu0.03602915See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks7.10.0360112See
SVNSlovenia pop 36.90.0350130See
BGDBangladesh Dhaka Bangalee0.0350141See
USAUSA Caucasian Bethesda7.00.0350307See
FRAFrance Southeast6.90.0350130See
ENGEngland Lancaster6.80.0346545See
FRAFrance Bordeaux6.90.0343990See
NORNorway pop 20.0340576See
AUSAustralia West Caucasian6.70.0340891See
ARGArgentina La Plata7.00.0340100See
ARGArgentina Buenos Aires6.80.0340466See
BIHBosnia and Herzegovina pop 26.70.0333120See
MEXMexico Veracruz, Poza Rica0.033345See
PRTPortugal Viana do Castelo0.0330706See
INDIndia Kerala Kuruma0.033015See
BRABrazil REDOME Bahia0.032147399See
PRTPortugal Castelo Branco0.0320327See
USAUSA African American Bethesda6.40.0320187See
FRAFrance Grenoble6.40.03181000See
FRAFrance Marseille6.40.03181000See
MEXMexico Tamaulipas Rural0.0317125See
MEXMexico Quintana Roo, Cancun0.031348See
GBRUnited Kingdom East0.0311163See
PRTPortugal North pop 20.03101801See
RUSRussia South Ural Russian6.30.0310207See
SENSenegal Dakar6.30.0310112See
ISRIsrael Jews pop 26.20.031023000See
BRABrazil Parana Caucasian6.30.03102775See
BRABrazil REDOME Sergipe0.03087321See
BRABrazil REDOME Santa Catarina0.0307106673See
FRAFrance Rennes pop 46.10.03061000See
RUSRussia Moscow0.03002650See
PRTPortugal Porto0.03007937See
BRABrazil Parana Cafuzo5.90.0300319See
BRABrazil REDOME Rio Grande do Sul0.0299241329See
BIHBosnia and Herzegovina0.0298134See
BRABrazil REDOME Pernambuco0.029492332See
BRABrazil REDOME Minas Gerais0.0293211275See
HRVCroatia pop 35.80.0292120See
NORNorway ethnic Norwegians5.80.02914510See
BRABrazil REDOME Goias0.029088574See
BRABrazil Rio Grande do Sul Caucasoid0.02904428See
BRABrazil Rio Grande do Sul Mixed0.0290324See
BRABrazil Sao Paulo Bauru Mixed0.02903542See
CMRCameroon Bamileke 20.029035See
ITAItaly Bergamo5.00.0290101See
MNGMongolia Tarialan Khoton0.029085See
BRABrazil REDOME Rio de Janeiro0.0289139322See
BRABrazil REDOME Espirito Santo0.028788485See
BRABrazil South East Cord Blood0.028611409See
FRAFrance Lyon5.70.02854813See
SDNSudan Central Shaigiya Mixed5.60.028436See
SAUSaudi Arabia5.60.028418See
SVKSlovakia pop 20.02834234See
BRABrazil REDOME Sao Paulo0.0282800809See
BRABrazil REDOME Tocantins0.028220692See
BRABrazil REDOME Rondonia0.028154396See
BRABrazil REDOME Alagoas0.028025349See
PRTPortugal Leiria0.02801847See
PRTPortugal Coimbra0.02805057See
ITAItaly North Pavia pop 25.50.02802416See
ITAItaly Sardinia pop30.0280100See
PRTPortugal Center pop 20.0280562See
ITAItaly Lombardy5.30.0280674See
MEXMexico Zacatecas Rural0.0279266See
BRABrazil REDOME Maranhao0.027910180See
BRABrazil REDOME Mato Grosso do Sul0.027995667See
BRABrazil REDOME Mato Grosso0.027734649See
BRABrazil REDOME Federal District0.027729549See
BRABrazil REDOME Parana0.0272341639See
ITAItaly pop 65.40.0272184See
BRABrazil Piaui Mixed0.027021943See
PRTPortugal Lisbon0.027017420See
RUSRussia Samara Region0.02702500See
MEXMexico Sinaloa Mestizo0.027056See
BRABrazil Parana Mulatto5.40.0270186See
CUBCuba Mixed pop 20.0270189See
BRABrazil REDOME Paraiba0.026743868See
COLColombia Barranquilla0.0265188See
MEXMexico Mexico City Metropolitan Area Rural0.0263150See
CMRCameroon Ewondo0.026038See
PRTPortugal Guarda0.0260797See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.026096See
PRTPortugal Evora0.0260737See
PRTPortugal Braga0.02601971See
ESPSpain North Cabuerniga0.026095See
DEUGermany Essen5.20.0260174See
BRABrazil REDOME Piaui0.025946140See
ITAItaly South Campania Region5.10.02581089See
RUSRussia Moscow Pop 25.10.02542000See
ESPSpain North5.00.0253156See
SAUSaudi Arabia pop 20.0250383See
PRTPortugal Setubal0.02505268See
BRABrazil South Ribeirao Preto0.0250184See
ALBAlbanian Kosovo0.0250120See
PRTPortugal South pop 20.02501021See
ARGArgentina Buenos Aires pop 24.90.02501216See
FRAFrance Grenoble, Nantes and Rennes0.02506094See
PAKPakistan Mixed Pathan0.0250100See
PAKPakistan Mixed Sindhi0.0250101See
BRABrazil REDOME Roraima0.02494140See
BRABrazil REDOME Ceara0.0245101217See
MEXMexico Durango Rural0.0245326See
SWESweden pop 44.80.0243966See
TZATanzania Dodoma Kongwa0.0240212See
PRTPortugal Aveiro0.02405933See
RUSRussia Chuvash0.024082See
TURTurkey pop 50.0240142See
THAThailand Northeast0.024066See
INDIndia Kerala Hindu Nair0.024041See
MNGMongolia Ulaanbaatar Khalkha0.024041See
COLColombia San Basilio de Palenque0.024042See
BRABrazil Paraná Caucasian4.70.0234641See
VENVenezuela Colonia Tovar0.023386See
BRABrazil REDOME Acre0.0233859See
IRNIran pop 10.023064See
PRTMadeira pop 20.0230173See
MARMorocco pop 20.0230110See
BRABrazil Rio Grande do Norte Mestizo0.023012973See
ESPSpain Ibiza0.023088See
ESPSpain Catalonia Girona0.023088See
BRABrazil REDOME Rio Grande do Norte0.022946603See
GRCGreece pop34.50.0227246See
RUSRussia Northwest4.50.02271011See
MEXMexico Queretaro, Queretaro city0.022245See
ITAItaly North Pavia pop 30.0221685See
PRTPortugal Bragança0.0220301See
USAUSA OPTN Hispanic0.02201580See
MMRMyanmar Bamar4.30.021747See
BRABrazil REDOME Para0.021672637See
MEXMexico Guanajuato Rural0.0215162See
RUSRussia Tatars0.0211355See
BRABrazil REDOME Amapa0.021017864See
PRTPortugal Beja0.0210699See
MEXMexico Mexico City Mestizo0.0210121See
BRABrazil REDOME Amazonas0.020924129See
MEXMexico Chihuahua Rural0.0209236See
CZECzech Republic Kurd4.10.020374See
VNMVietnam Hanoi0.020050See
PRTPortugal Faro0.02001242See
PRTPortugal Portalegre0.02001254See
PRTPortugal Santarem0.02003865See
BRABrazil Belem Mixed4.00.0200100See
MKDMacedonia pop 30.0200172See
ESPSpain Arratia Valley Basque0.020083See
ESPSpain Majorca0.0200407See
ITAItaly Rome4.00.0200100See
RUSRussia Arkhangelsk Pomor0.020063See
MNGMongolia Khalkha0.0200200See
HRVCroatia pop 20.0200100See
MEXMexico Baja Californa, Mexicali0.0200100See
RUSRussia Transbaikal Territory Buryats4.00.0200150See
MEXMexico Baja California, Tijuana0.020025See
MEXMexico Sinaloa Rural0.0191183See
ITAItaly North Pavia0.019081See
TWNTaiwan Chinese immigrants from Middle China0.0190211See
RUSRussia South Ural Tatar3.70.0190135See
SRBSerbia pop 33.80.01881992See
MEXMexico Hidalgo Rural0.018581See
BRABrazil Curitiba-Parana Mixed0.0185264See
CHLChile Santiago0.0185920See
MEXMexico Morelos, Cuernavaca0.018382See
GEOGeorgia Kurds0.018030See
GAZGaza Palestinians0.0180165See
ESPSpain Sevilla3.60.0180278See
ARMArmenia living in Iran0.018085See
ARGArgentina Cuyo Region3.50.0180420See
MEXMexico Veracruz, Coatzacoalcos0.017955See
MEXMexico Guerrero state0.0174144See
MKDMacedonia MBMDR - Macedonian3.40.01711283See
SRBSerbia Vojvodina3.50.0170400See
ARMArmenia Syunik0.0170117See
PRTMadeira pop 30.0170538See
MEXMexico Veracruz, Orizaba0.016760See
SWESweden Uppsala3.30.0166300See
MEXMexico Chiapas Rural0.0165121See
ROMRomania pop 33.10.01641469See
MEXMexico Coahuila Rural0.0161216See
MEXMexico Mexico City Mestizo pop 30.0160256See
MEXMexico Veracruz, Xalapa0.0160187See
ARMArmenia living in Lebanon0.0160368See
ARMArmenia Yerevan0.0160445See
THAThailand Northeast pop 20.0160400See
CHNChina Shandong Province3.10.01607418See
GRCGreece Crete0.0160135See
JPNJapan Hyogo3.10.016032See
ESPSpain Minorca0.016094See
CHNChina Jiangsu Province0.016020248See
MEXMexico Michoacan Rural0.0158348See
RUSRussia North Ossetian3.10.0157127See
MKDMacedonia MBMDR - Albanian3.10.0156128See
GRCGreece pop 70.015511250See
ARMArmenia Lori0.0150102See
CHNChina Shaanxi Province Han0.015010000See
MEXMexico Puebla Mestizo0.015099See
PAKPakistan Burusho0.015092See
ALBAlbania pop 22.80.0150432See
MEXMexico Mexico City West0.014933See
MEXMexico Mestizo pop 40.0149269See
MEXMexico Zacatecas, Fresnillo0.0143103See
RUSRussia South Ural Bashkir2.70.0140146See
IRNIran Royan Cord Blood Bank2.70.014015600See
PAKPakistan Brahui0.0140104See
IRNIran pop 40.0135855See
MEXMexico Michoacan, Morelia0.0132150See
MEXMexico Oaxaca, Oaxaca city0.0132151See
SAUSaudi Arabia pop 42.60.0131499See
ARGArgentina Corrientes2.60.0130155See
ARMArmenia living in USA0.0130233See
THAThailand pop 40.013016807See
CHNChina Wuhan2.50.0130121See
TURTurkey pop 20.0130228See
MYSMalaysia pop 30.01301445See
INDIndia Kerala Hindu Namboothiri0.013040See
MEXMexico Puebla, Puebla city0.01281994See
MEXMexico Guanajuato, Leon0.012878See
ECUEcuador Andes Mixed Ancestry0.0127824See
MEXMexico Tlaxcala Rural0.0127830See
ECUEcuador Coast Mixed Ancestry0.0126238See
MEXMexico Chihuahua Chihuahua City0.0126119See
MEXMexico Tabasco, Villahermosa0.012282See
ARMArmenia Ghegharkunik0.0120242See
KURIraq Kurdistan Region2.40.0120209See
MEXMexico Zacatecas, Zacatecas city0.011984See
MEXMexico Jalisco, Guadalajara city0.01171189See
MEXMexico Queretaro Rural0.011643See
ECUEcuador Mixed Ancestry0.01151173See
MEXMexico Coahuila, Torreon0.0113396See
MEXMexico Tlaxcala, Tlaxcala city0.0111181See
MEXMexico Veracruz Rural0.0111539See
ARMArmenia living in Karabakh0.0110445See
AREUnited Arab Emirates pop 22.10.0110373See
RUSRussia Northwest pop 22.20.0110346See
ESPSpain Majorca and Minorca0.011090See
GRCGreece North0.0110500See
MEXMexico Tabasco Rural0.0106142See
MEXMexico Campeche Rural0.010647See
COLColombia Wayu from Guajira Peninsula0.010448See
MEXMexico Nayarit, Tepic0.010397See
MEXMexico Quintana Roo Rural0.010050See
ITAItaly East Sicily2.00.010050See
ESPSpain Pas Valley0.010088See
TWNTaiwan Chinese immigrants from North China0.0100152See
VENVenezuela Caracas Mestizo0.010050See
RUSRussia Murmansk Saomi Mixed0.010070See
FRAFrance Corsica Island0.0100100See
CHNChina Shanghai0.010026266See
ROMRomania pop 20.01006936See
MYSMalaysia Sarawak Iban0.010051See
MYSMalaysia Sarawak Bidayuh0.010050See
FRAFrance Rennes pop 30.0100200See
MEXMexico Mexico City Center0.0097152See
ISRIsrael Moroccan Jews0.0090113See
GTMGuatemala Mayan0.0090132See
MEXMexico Jalisco, Zapopan0.0089168See
MEXMexico Colima, Colima city0.008261See
IRQIraq Erbil1.60.0081372See
TWNTaiwan Minnan pop 20.00807137See
USAUSA OPTN Asian0.0080261See
JPNJapan Hyogo Osaka and Nagano0.0080195See
MEXMexico Nayarit Rural0.007864See
MEXMexico Yucatan, Merida0.0077192See
MEXMexico Sonora Rural0.0076197See
CHNChina Shandong Province Linqu County1.50.0075139See
MEXMexico Oaxaca Rural0.0072485See
MEXMexico Sonora, Ciudad Obregón0.0070143See
BOLBolivia Quechua0.007080See
MNGMongolia Tsaatan0.0070144See
PAKPakistan Kalash0.007069See
MEXMexico Michoacan Tarasco1.50.0070130See
MEXMexico Mexico City North0.0066751See
MEXMexico Jalisco Rural0.0060585See
CHNChina Guangdong Province1.20.0060403See
MEXMexico San Luis Potosi Rural0.005787See
MEXMexico Aguascalientes state0.005395See
BRABrazil Parana Japanese1.00.0053192See
MEXMexico Sonora, Hermosillo0.005199See
CHLChile Santiago Mixed1.00.005070See
PAKPakistan Karachi Parsi0.005091See
TWNTaiwan Hakka pop 20.0050714See
MEXMexico Sinaloa, Culiacán0.0049103See
MEXMexico Puebla Rural0.0042833See
MYSMalaysia pop 20.004062See
MEXMexico Yucatan Rural0.0037132See
MEXMexico Nuevo Leon Rural0.0034439See
MEXMexico Durango, Durango city0.0032153See
PERPeru Arequipa Mestizo0.70.0030168See
KORSouth Korea pop 80.00307096See
MEXMexico Veracruz, Veracruz city0.0029171See
MEXMexico Nuevo Leon, Monterrey city0.0022226See
KORSouth Korea pop 10.0020324See
ITAItaly North pop 30.00.000097See
PRTPortugal North0.000046See
RUSRussia Nenet Mixed0.000055See
ARGArgentina Chiriguano0.00.000054See
ARGArgentina Salta Wichi pop 20.00.000019See
PAKPakistan Baloch0.000066See
MNGMongolia Oold0.0000104See
MEXMexico Nahuas0.000072See
MEXMexico Huasteca Region Teenek0.000055See
MEXMexico Mayan Pop 30.000066See
TWNTaiwan Aborigine0.0000111See
TWNTaiwan Chinese immigrants from South China0.0000172See
INDIndia Kerala Paniya0.000010See
INDIndia Kerala Kanikkar0.000022See
INDIndia Kerala Kattunaikka0.000017See
INDIndia Kerala Adiya0.000021See
BRABrazil Parana Oriental0.00.000033See
CHNChina North Han0.0000105See
BFABurkina Faso Fulani0.000049See
BFABurkina Faso Rimaibe0.000047See
INDIndia Kerala Hindu Pulaya0.000016See
INDIndia Kerala Hindu Ezhava0.000024See
CMRCameroon Uldeme0.000035See
CMRCameroon Podokwo0.000043See
JPNJapan Tohoku Region0.0000322See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.000094See
MYSMalaysia Negeri Sembilan Minangkabau0.000034See
MYSMalaysia Perak Rawa0.000023See
MEXMexico Guanajuato, Guanajuato city0.000022See
MEXMexico San Luis Potosi, San Luis Potosi city0.000030See
MEXMexico Jalisco, Tonala0.000035See
MEXMexico Jalisco, Tlaquepaque0.000039See
MEXMexico Jalisco, Tlajomulco0.000030See
MEXMexico Coahuila, Saltillo0.000072See
MEXMexico Hidalgo, Pachuca0.000041See
MEXMexico Veracruz, Cordoba0.000056See
MEXMexico Mexico City East0.000079See
MEXMexico Mexico City South0.000052See
MEXMexico Campeche, Campeche city0.000034See
ECUEcuador Amazonia Mixed Ancestry0.000039See
MEXMexico Chihuahua, Ciudad Juarez0.0000106See
MEXMexico Baja California, La Paz0.000075See
MEXMexico Baja California Rural0.000050See
MEXMexico Colima Rural0.000043See
MEXMexico Morelos Rural0.000030See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

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