Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 400 time(s) and present in 388 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
ARGArgentina Rosario Toba59.30.360086See
ARGArgentina Chiriguano43.40.264054See
ARGArgentina Salta Wichi pop 247.40.237019See
MEXMexico Michoacan Tarasco33.80.1840130See
COLColombia Wayu from Guajira Peninsula0.156348See
MEXMexico Quintana Roo Rural0.150050See
JPNJapan Hyogo28.10.141032See
MEXMexico Huasteca Region Teenek0.121055See
MEXMexico Morelos Rural0.116730See
ARGArgentina Corrientes20.60.1130155See
MEXMexico Yucatan Rural0.1119132See
GTMGuatemala Mayan0.1090132See
JPNJapan Kyoto and Osaka0.1090165See
MEXMexico Veracruz, Coatzacoalcos0.107155See
MEXMexico Sinaloa, Culiacán0.1068103See
BRABrazil Parana Oriental21.20.106033See
BRABrazil REDOME Amazonas0.105524129See
JPNJapan Hyogo Osaka and Nagano0.1030195See
BRABrazil REDOME Amapa0.102117864See
PERPeru Lamas City Lama0.102083See
JPNJapan pop 20.1000916See
MEXMexico San Luis Potosi, San Luis Potosi city0.100030See
MEXMexico Sonora, Hermosillo0.096099See
BRABrazil REDOME Para0.095872637See
MEXMexico Zacatecas, Fresnillo0.0952103See
MEXMexico Tabasco Rural0.0951142See
MEXMexico Yucatan, Merida0.0949192See
MEXMexico Nayarit Rural0.093864See
MEXMexico Mexico City West0.090933See
MEXMexico Mexico City South0.086552See
MEXMexico Veracruz, Xalapa0.0856187See
MEXMexico Morelos, Cuernavaca0.085482See
MNGMongolia Khalkha0.0850200See
MEXMexico Nuevo Leon, Monterrey city0.0841226See
MEXMexico Durango, Durango city0.0839153See
MEXMexico Zacatecas, Zacatecas city0.083384See
BRABrazil REDOME Roraima0.08314140See
INDIndia Kerala Hindu Ezhava0.083024See
CHNChina Yunnan Province Naxi0.0830118See
INDIndia Bikaner Raikas16.00.0830143See
MEXMexico Guanajuato Rural0.0828162See
ARGArgentina La Plata16.00.0810100See
MEXMexico Nuevo Leon Rural0.0807439See
MEXMexico Sonora, Ciudad Obregón0.0804143See
BRABrazil Rio Grande do Sul Black0.0800248See
MEXMexico Colima Rural0.079543See
MEXMexico Veracruz, Veracruz city0.0785171See
MEXMexico Queretaro, Queretaro city0.077845See
ECUEcuador Coast Mixed Ancestry0.0777238See
ARGArgentina Cuyo Region14.70.0770420See
SDNSudan East Rashaida14.80.076927See
MEXMexico Puebla Mestizo0.076099See
JPNJapan Aichi15.20.076050See
INDIndia Bikaner Non-Raikas14.60.0760127See
MEXMexico Coahuila, Saltillo0.075372See
VENVenezuela Zulia Maracaibo Mixed0.075020See
MEXMexico Puebla Rural0.0749833See
MEXMexico Campeche Rural0.074547See
MEXMexico Chihuahua, Ciudad Juarez0.0741106See
MEXMexico Veracruz Rural0.0730539See
BOLBolivia Quechua0.073080See
MKDMacedonia MBMDR - Macedonian Muslims13.20.072476See
MEXMexico Chihuahua Chihuahua City0.0714119See
BRABrazil Rio Grande do Sul Mixed0.0700324See
MNGMongolia Khalkha pop 20.0700202See
MEXMexico Mexico City Metropolitan Area Rural0.0691150See
SAUSaudi Arabia pop 20.0690383See
BRABrazil REDOME Maranhao0.068410180See
MEXMexico Guanajuato, Guanajuato city0.068222See
MEXMexico Tabasco, Villahermosa0.067182See
MEXMexico Nayarit, Tepic0.067097See
MEXMexico Jalisco, Tlajomulco0.066730See
MEXMexico Oaxaca Rural0.0667485See
SAUSaudi Arabia pop 412.60.0661499See
MEXMexico Mexico City Mestizo pop 30.0660256See
MEXMexico Tamaulipas, Ciudad Victoria0.065223See
BRABrazil Parana Japanese14.00.0650192See
BRABrazil Piaui Mixed0.065021943See
MNGMongolia Tarialan Khoton0.065085See
MNGMongolia Hoton0.065085See
MEXMexico Puebla, Puebla city0.06491994See
MEXMexico Chihuahua Rural0.0649236See
MEXMexico Jalisco, Tlaquepaque0.064139See
MEXMexico Jalisco Rural0.0640585See
ARGArgentina Buenos Aires pop 211.80.06401216See
MEXMexico San Luis Potosi Rural0.063287See
MEXMexico Michoacan Rural0.0630348See
MEXMexico Michoacan, Morelia0.0629150See
BRABrazil REDOME Piaui0.062646140See
MEXMexico Guerrero state0.0625144See
BRABrazil REDOME Ceara0.0624101217See
MEXMexico Hidalgo Rural0.061781See
INDIndia Kerala Hindu Nair0.061041See
MEXMexico Sinaloa Rural0.0601183See
INDIndia Delhi pop 212.20.060090See
BRABrazil REDOME Acre0.0594859See
BRABrazil Curitiba-Parana Mixed0.0594264See
JPNJapan pop 1111.30.058162See
VENVenezuela Sierra de Perija Yucpa0.058073See
MNGMongolia Oold0.0580104See
MEXMexico Chiapas Rural0.0579121See
SAUSaudi Arabia11.10.057118See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.057096See
BRABrazil REDOME Mato Grosso do Sul0.056695667See
CHLChile Santiago0.0565920See
MEXMexico Jalisco, Guadalajara city0.05651189See
MEXMexico Mexico City East0.056379See
CHNChina Harbin Korean0.0550201See
MEXMexico Mexico City North0.0538751See
MEXMexico Tlaxcala Rural0.0536830See
BRABrazil REDOME Rio Grande do Norte0.053446603See
MEXMexico Baja California, La Paz0.053375See
RUSRussia Transbaikal Territory Buryats9.00.0530150See
KORSouth Korea pop 10.0530324See
BRABrazil Rio Grande do Norte Mestizo0.053012973See
USAUSA OPTN Hispanic0.05301580See
BRABrazil REDOME Mato Grosso0.052734649See
MEXMexico Aguascalientes state0.052695See
MEXMexico Quintana Roo, Cancun0.052148See
MEXMexico Durango Rural0.0520326See
ECUEcuador Amazonia Mixed Ancestry0.051339See
BRABrazil REDOME Tocantins0.051120692See
KORSouth Korea pop 80.05107096See
BRABrazil Parana Mulatto10.20.0510186See
BRABrazil REDOME Alagoas0.050925349See
MEXMexico Sonora Rural0.0508197See
BRABrazil REDOME Parana0.0506341639See
BRABrazil REDOME Paraiba0.050343868See
MEXMexico Zacatecas Rural0.0502266See
MEXMexico Baja Californa, Mexicali0.0500100See
BRABrazil Pernambuco Mixed0.0500101See
MEXMexico Mexico City Mestizo0.0500121See
VENVenezuela Zulia San Jose de Heras Mixed0.050020See
MEXMexico Tlaxcala, Tlaxcala city0.0497181See
MEXMexico Oaxaca, Oaxaca city0.0497151See
BRABrazil REDOME Rondonia0.049554396See
BRABrazil Rio Grande do Sul Caucasoid0.04904428See
MNGMongolia Ulaanbaatar Khalkha0.049041See
RUSRussia Chuvash0.049082See
MNGMongolia Tsaatan0.0490144See
BRABrazil REDOME Rio Grande do Sul0.0489241329See
MEXMexico Mexico City Center0.0487152See
INDIndia Kerala Syrian Christian0.048031See
MEXMexico Jalisco, Zapopan0.0476168See
RUSRussia Sakhalin Island Nivkhi0.047053See
FRAFrance Southeast9.20.0470130See
MEXMexico Mestizo pop 40.0465269See
BRABrazil REDOME Santa Catarina0.0460106673See
BGDBangladesh Dhaka Bangalee0.0460141See
MEXMexico Coahuila Rural0.0459216See
MEXMexico Coahuila, Torreon0.0450396See
MEXMexico Sinaloa Mestizo0.045056See
BRABrazil REDOME Federal District0.044529549See
MEXMexico Veracruz, Poza Rica0.044445See
MEXMexico Campeche, Campeche city0.044134See
PAKPakistan Mixed Sindhi0.0440101See
BRABrazil South Ribeirao Preto0.0440184See
RUSRussia South Ural Bashkir8.20.0440146See
ECUEcuador Mixed Ancestry0.04391173See
ENGEngland Lancaster8.60.0439545See
BRABrazil REDOME Pernambuco0.043792332See
BRABrazil Parana Caucasian8.60.04302775See
MEXMexico Jalisco, Tonala0.042935See
COLColombia Barranquilla0.0425188See
BRABrazil REDOME Goias0.042288574See
BRABrazil REDOME Sao Paulo0.0421800809See
AUSAustralia West Caucasian8.20.0420891See
BRABrazil Sao Paulo Bauru Mixed0.04203542See
BRABrazil REDOME Espirito Santo0.041588485See
MEXMexico Colima, Colima city0.041061See
CHNChina Shandong Province8.00.04107418See
PRTPortugal Viana do Castelo0.0400706See
CHNChina Shaanxi Province Han0.040010000See
PERPeru Arequipa Mestizo7.40.0400168See
BOLBolivia Aymara0.0400102See
MEXMexico Baja California Rural0.040050See
MEXMexico Tamaulipas Rural0.0397125See
INDIndia Jalpaiguri Toto7.50.038240See
ESPSpain North Cabuerniga0.038095See
BRABrazil REDOME Sergipe0.03787321See
SWESweden Uppsala7.40.0377300See
MEXMexico Chiapas, Tuxtla Gutierrez0.037752See
BRABrazil South East Cord Bllod0.037611409See
BRABrazil REDOME Rio de Janeiro0.0371139322See
CHNChina Jiangsu Province0.037020248See
INDIndia North pop 30.0370587See
CHNChina Shanghai0.036026266See
USAUSA OPTN Asian0.0360261See
DEUGermany Essen6.90.0360174See
ECUEcuador Andes Mixed Ancestry0.0358824See
LKASri Lanka Colombo Sinhalese0.0350101See
PRTMadeira pop 20.0350173See
USAUSA Philadelphia Caucasian7.10.0350141See
VENVenezuela Colonia Tovar0.034986See
BRABrazil REDOME Minas Gerais0.0345211275See
SWESweden Stockholm6.80.03401347See
FRAFrance Rennes pop 46.80.03391000See
GBRUnited Kingdom Central0.0337135See
NORNorway ethnic Norwegians6.60.03354510See
MEXMexico Veracruz, Orizaba0.033360See
HRVCroatia pop 36.70.0333120See
FRAFrance Lyon6.60.03314813See
BRABrazil Parana Cafuzo6.60.0330319See
CHNChina Harbin Manchu0.0330172See
BRABrazil Paraná Caucasian6.40.0328641See
ITAItaly pop 66.00.0326184See
MEXMexico Guanajuato, Leon0.032178See
ARGArgentina Buenos Aires6.40.0320466See
TWNTaiwan Chinese immigrants from North China0.0320152See
BRABrazil Minas Gerais State Mixed6.40.03201000See
BRABrazil REDOME Bahia0.031347399See
FRAFrance Bordeaux6.20.0312990See
SVNSlovenia pop 36.20.0310130See
INDIndia Kerala Hindu Pulaya0.031016See
GBRUnited Kingdom South West0.0307163See
DZAAlgeria pop 26.00.0304106See
GBRUnited Kingdom North0.0303330See
BRABrazil Sao Paulo Mixed0.60.0300239See
USAUSA OPTN Caucasian0.03008525See
FRAFrance Grenoble5.90.02931000See
FRAFrance Marseille5.80.02921000See
CMRCameroon Uldeme0.029035See
WALWales pop 25.60.029039979See
HRVCroatia pop 20.0290100See
INDIndia Kerala Malabar Muslim0.029034See
FRAFrance Grenoble, Nantes and Rennes0.02906094See
PRTPortugal Castelo Branco0.0290327See
TURTurkey pop 20.0290228See
ARMArmenia living in Iran0.029085See
ENGEngland Leeds5.70.02895024See
ENGEngland Sheffield5.60.02844755See
PRTPortugal Coimbra0.02805057See
PRTPortugal Setubal0.02805268See
AREUnited Arab Emirates pop 25.60.0280373See
SVKSlovakia pop 20.02804234See
ITAItaly Lombardy5.60.0280674See
ENGEngland North West Mixed pop 25.50.0277379See
ENGEngland Manchester5.40.02731640See
PRTPortugal North pop 20.02731801See
ITAItaly Bergamo5.00.0270101See
ESPSpain Minorca0.027094See
MARMorocco pop 20.0270110See
PRTPortugal Viseu0.02702915See
PRTPortugal Faro0.02701242See
ITAItaly North Pavia pop 25.30.02702416See
PRTPortugal Braga0.02601971See
CMRCameroon Ewondo0.026038See
ENGEngland London Ashkenazi Jews0.0260500See
PRTPortugal South pop 20.02601021See
ESPSpain Majorca0.0260407See
PRTPortugal Center pop 20.0260562See
ARMArmenia living in Karabakh0.0260445See
ARMArmenia Shirak0.026076See
ENGEngland Liverpool5.10.02581343See
RUSRussia Northwest pop 35.00.0250100See
BIHBosnia and Herzegovina pop 25.00.0250120See
PRTPortugal Porto0.02507937See
TWNTaiwan Minnan and Hakka0.0250190See
ARMArmenia Lori0.0250102See
MEXMexico Hidalgo, Pachuca0.024441See
ENGEngland Newcastle4.80.02432739See
GBRUnited Kingdom renal patients4.80.02407007See
PRTPortugal Lisbon0.024017420See
PRTPortugal Aveiro0.02405933See
CUBCuba Mulatto4.80.024042See
MEXMexico Mestizo4.90.024041See
MMRMyanmar Mon4.70.023464See
MEXMexico Queretaro Rural0.023343See
ITAItaly North Pavia pop 30.0232685See
PRTPortugal Bragança0.0230301See
PRTPortugal Santarem0.02303865See
PRTPortugal Leiria0.02301847See
MMRMyanmar Kayin4.50.022744See
POLPoland pop 34.50.02252907See
SWESweden pop 44.40.0223966See
PAKPakistan Burusho0.022092See
KURIraq Kurdistan Region4.30.0220209See
RUSRussia Samara Region0.02202500See
RUSRussia South Ural Tatar4.40.0220135See
IRLIreland South pop 20.021717624See
ARMArmenia living in USA0.0210233See
ARMArmenia Ghegharkunik0.0210242See
GRCGreece pop34.10.0207246See
CZECzech Republic Kurd4.10.020374See
IRQIraq Erbil4.00.0202372See
MEXMexico Baja California, Tijuana0.020025See
PRTPortugal Vila Real0.02001167See
PRTMadeira pop 30.0200538See
PRTPortugal Evora0.0200737See
FRAFrance Rennes pop 30.0200200See
MYSMalaysia Perak Rawa0.020023See
VNMVietnam Hanoi0.020050See
ROMRomania pop 20.02006936See
RUSRussia Moscow0.02002650See
BFABurkina Faso Fulani0.020049See
RUSRussia Nenet Mixed0.020055See
RUSRussia Arkhangelsk Pomor0.020063See
ITAItaly East Sicily4.00.020050See
VENVenezuela Caracas Mestizo0.020050See
MKDMacedonia pop 30.0200172See
ESPSpain Sevilla4.00.0198278See
RUSRussia North Ossetian3.90.0197127See
RUSRussia Moscow Pop 23.90.01952000See
SRBSerbia pop 33.80.01931992See
ROMRomania pop 33.80.01911469See
GRCGreece pop 70.019111250See
RUSRussia South Ural Russian3.90.0190207See
BIHBosnia and Herzegovina0.0186134See
MMRMyanmar Chin3.60.018255See
CHNChina Shandong Province Linqu County3.60.0181139See
RUSRussia Northwest3.60.01811011See
ESPSpain North Cantabria0.018083See
TURTurkey pop 50.0180142See
PRTPortugal Guarda0.0180797See
MEXMexico Veracruz, Cordoba0.017956See
CHNChina Guangdong Province3.50.0176403See
PRTPortugal Beja0.0170699See
PRTPortugal Portalegre0.01701254See
ISRIsrael Jews pop 23.30.017023000See
TWNTaiwan Chinese immigrants from Middle China0.0170211See
CHNChina Wuhan3.30.0170121See
GEOGeorgia Kurds0.017030See
ARMArmenia Syunik0.0170117See
RUSRussia Tatars0.0169355See
MKDMacedonia MBMDR - Macedonian3.40.01681283See
ITAItaly South Campania Region3.30.01661089See
INDIndia North Gujarat3.30.0163338See
GRCGreece North0.0160500See
ISRIsrael Ashkenazi Jews pop 20.0160132See
ESPSpain Pas Valley0.016088See
GBRUnited Kingdom East0.0153163See
SRBSerbia Vojvodina3.00.0150400See
TWNTaiwan Chinese immigrants from South China0.0150172See
ARMArmenia living in Lebanon0.0150368See
MARMorocco Casablanca0.0150100See
IRNIran Royan Cord Blood Bank2.90.015015600See
RUSRussia Northwest pop 22.70.0140346See
MKDMacedonia pop 40.0140216See
ESPSpain Arratia Valley Basque0.013083See
USAUSA OPTN African American0.01301510See
BRABrazil Parana Afro Brazilian2.60.013077See
INDIndia Kerala Hindu Namboothiri0.013040See
THAThailand pop 40.013016807See
ZAFSouth Africa Tswana2.40.012041See
CMRCameroon Podokwo0.012043See
TWNTaiwan Minnan pop 20.01207137See
GAZGaza Palestinians0.0120165See
ARMArmenia Yerevan0.0120445See
MKDMacedonia MBMDR - Albanian2.30.0117128See
GBRUnited Kingdom Orkney0.011488See
IRNIran pop 40.0111855See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.011094See
SDNSudan South Nuba2.20.011046See
ALBAlbania pop 22.10.0104432See
MMRMyanmar Rakhine2.10.010448See
RUSRussia Murmansk Saomi Mixed0.010070See
GRCGreece Crete0.0100135See
TTOTrinidad South Asian0.010087See
MYSMalaysia pop 30.01001445See
GBRUnited Kingdom pop 20.0100101See
FRAFrance Reims0.0100102See
MMRMyanmar Kayah1.80.009155See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks1.80.0090112See
MYSMalaysia Sabah Kadazan0.009057See
BFABurkina Faso Mossi0.009053See
ISRIsrael Moroccan Jews0.0090113See
MYSMalaysia pop 20.008062See
CUBCuba Mixed pop 20.0080189See
CUBCuba Mixed0.008078See
TWNTaiwan Hakka pop 20.0070714See
ITAItaly North Pavia0.006081See
ESPSpain Majorcans Jews0.0050103See
ITAItaly Rome1.00.0050100See
ZAFSouth Africa Natal Zulu1.00.0050100See
ALBAlbanian Kosovo0.0042120See
ESPSpain Murcia0.0040173See
ITAItaly North pop 30.00.000097See
ESPSpain Ibiza0.000088See
TTOTrinidad African0.000067See
TWNTaiwan Aborigine0.0000111See
CMRCameroon Bamileke 20.000035See
BFABurkina Faso Rimaibe0.000047See
PAKPakistan Karachi Parsi0.000091See
CHNChina Yunnan Province Han pop 20.0000129See
CHNChina North Han0.0000105See
MYSMalaysia Negeri Sembilan Minangkabau0.000034See

See also higher resolution data of this allele

Allele  Number of Populations 
 A*31:01 146 
 A*31:01:02 188 
 A*31:02 47 
 A*31:03 47 
 A*31:04 47 
 A*31:05 16 
 A*31:06 23 
 A*31:07 14 
 A*31:08 58 
 A*31:09 36 
 A*31:12 13 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

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