Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 414 time(s) and present in 387 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
ITAItaly Sardinia pop30.2620100See
ALBAlbanian Kosovo0.2000120See
MKDMacedonia MBMDR - Macedonian Muslims34.20.184276See
MKDMacedonia pop 30.1660172See
MYSMalaysia Negeri Sembilan Minangkabau0.160034See
ALBAlbania pop 228.00.1574432See
FRAFrance Corsica Island0.1520100See
MKDMacedonia MBMDR - Albanian26.60.1445128See
GRCGreece pop326.80.1444246See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.138094See
MKDMacedonia pop 40.1340216See
MKDMacedonia MBMDR - Macedonian25.20.13371283See
ROMRomania pop 321.50.11401469See
GRCGreece pop 70.112911250See
ITAItaly South Campania Region21.10.11171089See
MYSMalaysia Sarawak Iban0.108051See
MYSMalaysia pop 20.106062See
HRVCroatia pop 20.1030100See
GRCGreece North0.1030500See
MYSMalaysia pop 30.10201445See
ESPSpain Gipuzkoa Basque0.1010100See
ROMRomania pop 20.10006936See
ITAItaly Rome19.00.1000100See
TZATanzania Dodoma Kongwa0.1000212See
ITAItaly East Sicily20.00.100050See
ITAItaly Lombardy18.70.0990674See
SRBSerbia pop 318.40.09891992See
ITAItaly pop 618.50.0978184See
ITAItaly North Pavia pop 218.10.09702416See
ESPSpain Majorca0.0960407See
SRBSerbia Vojvodina18.00.0930400See
MEXMexico Queretaro Rural0.093043See
ESPSpain Sevilla18.40.0917278See
ITAItaly North Pavia pop 30.0915685See
ESPSpain Andalusia0.088099See
ITAItaly Bergamo16.80.0870101See
SVKSlovakia pop 20.08484234See
RUSRussia Moscow0.08402650See
HRVCroatia pop 316.70.0833120See
BIHBosnia and Herzegovina pop 215.80.0833120See
BIHBosnia and Herzegovina0.0820134See
RUSRussia Samara Region0.08202500See
ARGArgentina La Plata16.00.0810100See
POLPoland pop 315.90.08092907See
SVNSlovenia pop 315.40.0800130See
RUSRussia Northwest pop 215.40.0800346See
THAThailand Northeast0.080066See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks16.10.0800112See
PRTPortugal Beja0.0790699See
FRAFrance Reims0.0780102See
FRAFrance Bordeaux15.50.0775990See
RUSRussia Moscow Pop 215.00.07752000See
PRTPortugal North0.076046See
GRCGreece Crete0.0750135See
THAThailand Northeast pop 20.0750400See
RUSRussia South Ural Tatar14.80.0740135See
ITAItaly North Pavia0.074081See
FRAFrance Marseille14.70.07381000See
RUSRussia Northwest14.20.07371011See
ESPSpain North14.00.0726156See
ARGArgentina Buenos Aires pop 213.80.07201216See
PRTPortugal Faro0.07201242See
ESPSpain Murcia0.0710173See
CUBCuba Mixed0.070078See
MYSMalaysia Perak Rawa0.070023See
FRAFrance Grenoble13.90.06981000See
ESPSpain Catalonia Girona0.069088See
MARMorocco pop 20.0680110See
ARMArmenia living in Lebanon0.0670368See
RUSRussia Chuvash0.067082See
RUSRussia North Ossetian13.40.0669127See
MEXMexico Jalisco, Tlajomulco0.066730See
ESPSpain North Cantabria0.066083See
ARMArmenia Shirak0.066076See
ARMArmenia Ghegharkunik0.0660242See
PRTPortugal Evora0.0660737See
AUTAustria Cord Bloods0.06571368See
RUSRussia Northwest pop 312.00.0650100See
ESPSpain Minorca0.065094See
BRABrazil Paraná Caucasian12.90.0647641See
MEXMexico Chihuahua Chihuahua City0.0630119See
TURTurkey pop 50.0630142See
INDIndia Kerala Hindu Namboothiri0.063040See
PRTPortugal Leiria0.06301847See
PRTPortugal Portalegre0.06301254See
PRTPortugal Santarem0.06203865See
PRTPortugal South pop 20.06101021See
FRAFrance Grenoble, Nantes and Rennes0.06106094See
CZECzech Republic Kurd12.20.060874See
IRQIraq Erbil12.10.0606372See
FRAFrance Lyon12.10.06024813See
ARMArmenia Syunik0.0600117See
FRAFrance Rennes pop 30.0600200See
MEXMexico Baja California Rural0.060050See
INDIndia Kerala Kattunaikka0.059017See
MEXMexico Sinaloa, Culiacán0.0583103See
GAZGaza Palestinians0.0580165See
CMRCameroon Podokwo0.058043See
RUSRussia Tatars0.0577355See
MEXMexico Jalisco, Tonala0.057135See
SAUSaudi Arabia11.10.057118See
ISRIsrael Jews pop 211.00.057023000See
PRTPortugal Setubal0.05705268See
RUSRussia South Ural Russian11.10.0560207See
ISRIsrael Moroccan Jews0.0560113See
MEXMexico Veracruz, Poza Rica0.055645See
MEXMexico Baja Californa, Mexicali0.0550100See
ARGArgentina Buenos Aires10.90.0550466See
BRABrazil Parana Caucasian11.00.05502775See
ECUEcuador Coast Mixed Ancestry0.0546238See
GEOGeorgia Kurds0.054030See
ARGArgentina Cuyo Region10.60.0540420See
ARMArmenia Lori0.0540102See
MEXMexico Mestizo pop 40.0539269See
BRABrazil REDOME Sao Paulo0.0534800809See
CHLChile Santiago0.0533920See
KURIraq Kurdistan Region10.50.0530209See
PRTPortugal Lisbon0.053017420See
PRTPortugal Aveiro0.05305933See
ESPSpain Arratia Valley Basque0.053083See
BRABrazil REDOME Espirito Santo0.052988485See
BRABrazil REDOME Parana0.0526341639See
GBRUnited Kingdom North0.0522330See
PRTPortugal Coimbra0.05205057See
BRABrazil Parana Afro Brazilian10.40.052077See
TUNTunisia pop 30.0510104See
PRTPortugal Vila Real0.05101167See
BRABrazil Sao Paulo Bauru Mixed0.05103542See
ARMArmenia Yerevan0.0510445See
BRABrazil REDOME Rio Grande do Sul0.0509241329See
BRABrazil Belem Mixed10.00.0500100See
ESPSpain Majorca and Minorca0.050090See
BRABrazil Pernambuco Mixed0.0500101See
MEXMexico Veracruz, Orizaba0.050060See
MEXMexico Morelos Rural0.050030See
BRABrazil REDOME Santa Catarina0.0494106673See
BRABrazil Rio Grande do Sul Caucasoid0.04904428See
PRTPortugal Braga0.04901971See
PRTPortugal Porto0.04907937See
PRTPortugal Castelo Branco0.0490327See
IRNIran Royan Cord Blood Bank9.70.049015600See
ZAFSouth Africa Tswana7.30.049041See
AREUnited Arab Emirates pop 29.40.0480373See
BRABrazil REDOME Sergipe0.04777321See
MEXMexico Coahuila, Torreon0.0475396See
BRABrazil South East Cord Blood0.047411409See
BRABrazil REDOME Mato Grosso0.047134649See
ARMArmenia living in USA0.0470233See
BRABrazil South Ribeirao Preto0.0470184See
USAUSA OPTN Caucasian0.04708525See
FRAFrance Southeast9.20.0470130See
MEXMexico Nayarit Rural0.046964See
BRABrazil REDOME Rondonia0.046854396See
PRTPortugal North pop 20.04651801See
BRABrazil Sao Paulo Mixed0.90.0460239See
PAKPakistan Baloch0.046066See
FRAFrance Rennes pop 49.10.04561000See
GBRUnited Kingdom Central0.0451135See
GBRUnited Kingdom pop 20.0450101See
BRABrazil Parana Mixed race9.10.0450186See
PAKPakistan Mixed Sindhi0.0450101See
MEXMexico Mexico City West0.044833See
MEXMexico Veracruz, Cordoba0.044656See
MEXMexico Queretaro, Queretaro city0.044445See
SWESweden Uppsala8.70.0444300See
ENGEngland Liverpool8.70.04441343See
INDIndia North Gujarat8.60.0444338See
BRABrazil REDOME Mato Grosso do Sul0.044395667See
INDIndia sub-Himalayan West Bengal Kami8.90.0443158See
ARMArmenia living in Karabakh0.0440445See
MYSMalaysia Sabah Kadazan0.044057See
PRTMadeira pop 30.0440538See
BRABrazil Parana Cafuzo8.80.0440319See
BRABrazil REDOME Minas Gerais0.0439211275See
BRABrazil REDOME Federal District0.043829549See
BRABrazil REDOME Rio de Janeiro0.0435139322See
CZECzech Republic Romani pop 28.70.043546See
GBRUnited Kingdom East0.0435163See
CMRCameroon Uldeme0.043035See
PRTPortugal Guarda0.0430797See
PRTPortugal Bragança0.0430301See
BRABrazil Minas Gerais State Mixed8.40.04301000See
BRABrazil REDOME Goias0.043088574See
BFABurkina Faso Rimaibe0.043047See
CUBCuba Mixed pop 20.0430189See
BRABrazil REDOME Bahia0.042947399See
MEXMexico Guanajuato Rural0.0429162See
BRABrazil REDOME Ceara0.0427101217See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.042096See
PRTPortugal Center pop 20.0420562See
USAUSA African American Bethesda8.50.0420187See
MEXMexico Nuevo Leon, Monterrey city0.0420226See
GBRUnited Kingdom Orkney0.041988See
ENGEngland Manchester8.20.04181640See
MEXMexico Jalisco, Zapopan0.0417168See
MEXMexico Durango Rural0.0413326See
BRABrazil Curitiba-Parana Mixed0.0412264See
ENGEngland London Ashkenazi Jews0.0410500See
MNGMongolia Tarialan Khoton0.041085See
MEXMexico Nuevo Leon Rural0.0409439See
BRABrazil REDOME Tocantins0.040820692See
BRABrazil REDOME Alagoas0.040725349See
TTOTrinidad South Asian0.040087See
MEXMexico Baja California, La Paz0.040075See
IRNIran pop 40.0398855See
ENGEngland Sheffield7.80.03974755See
BRABrazil REDOME Maranhao0.039310180See
ENGEngland Leeds7.70.03925024See
PRTAzores Terceira Island0.0390130See
SCOScotland Orkney7.80.039099See
PRTPortugal Viana do Castelo0.0390706See
THAThailand pop 40.039016807See
MEXMexico Mexico City Center0.0390152See
MEXMexico Jalisco, Tlaquepaque0.038539See
BRABrazil REDOME Roraima0.03854140See
BRABrazil REDOME Pernambuco0.038192332See
BRABrazil Rio Grande do Sul Mixed0.0380324See
BRABrazil Rio Grande do Norte Mestizo0.038012973See
PRTPortugal Viseu0.03802915See
PAKPakistan Karachi Parsi0.038091See
MEXMexico Veracruz, Veracruz city0.0378171See
SDNSudan East Rashaida7.40.037727See
BRABrazil REDOME Rio Grande do Norte0.037746603See
MEXMexico Chiapas Rural0.0372121See
ENGEngland Newcastle7.30.03712739See
MARMorocco Casablanca0.0370100See
USAUSA OPTN Hispanic0.03701580See
AUSAustralia West Caucasian7.30.0370891See
MMRMyanmar Shan7.40.037054See
NORNorway ethnic Norwegians7.20.03674510See
MEXMexico Coahuila Rural0.0367216See
ENGEngland Lancaster7.20.0366545See
MMRMyanmar Kayah7.30.036455See
ISRIsrael Ashkenazi Jews pop 20.0360132See
BRABrazil Piaui Mixed0.036021943See
MEXMexico Sinaloa Mestizo0.036056See
BRABrazil REDOME Piaui0.035946140See
IRLIreland South pop 20.035717624See
BRABrazil REDOME Paraiba0.035643868See
DZAAlgeria pop 27.00.0356106See
GBRUnited Kingdom South West0.0354163See
MEXMexico Puebla Mestizo0.035099See
WALWales pop 27.00.035039979See
MEXMexico Colima Rural0.034143See
RUSRussia South Ural Bashkir6.80.0340146See
MEXMexico Zacatecas, Fresnillo0.0333103See
BRABrazil REDOME Acre0.0332859See
BRABrazil REDOME Para0.033172637See
ESPSpain North Cabuerniga0.033095See
MEXMexico Mexico City Metropolitan Area Rural0.0329150See
ECUEcuador Mixed Ancestry0.03281173See
MEXMexico Guanajuato, Leon0.032178See
MEXMexico Veracruz, Xalapa0.0321187See
INDIndia Kerala Syrian Christian0.032031See
BRABrazil Rio Grande do Sul Black0.0320248See
PRTMadeira pop 20.0320173See
BRABrazil REDOME Amazonas0.031824129See
MEXMexico Puebla, Puebla city0.03181994See
SWESweden pop 46.20.0316966See
MEXMexico Sonora, Ciudad Obregón0.0315143See
INDIndia North pop 30.0310587See
TURTurkey pop 20.0310228See
MEXMexico Michoacan Rural0.0301348See
SAUSaudi Arabia pop 20.0300383See
COLColombia Barranquilla0.0295188See
MEXMexico Jalisco, Guadalajara city0.02931189See
VENVenezuela Colonia Tovar0.029186See
MEXMexico Durango, Durango city0.0290153See
ECUEcuador Andes Mixed Ancestry0.0285824See
MEXMexico Jalisco Rural0.0282585See
BFABurkina Faso Mossi0.028053See
BRABrazil REDOME Amapa0.027617864See
MEXMexico Coahuila, Saltillo0.027472See
MEXMexico Mexico City Mestizo pop 30.0270256See
NORNorway pop 20.0270576See
USAUSA OPTN African American0.02701510See
ESPSpain Pas Valley0.027088See
MEXMexico Tlaxcala Rural0.0265830See
MEXMexico Aguascalientes state0.026395See
USAUSA OPTN Asian0.0260261See
CMRCameroon Ewondo0.026038See
ARGArgentina Corrientes3.90.0260155See
MEXMexico Nayarit, Tepic0.025897See
MEXMexico Chihuahua Rural0.0251236See
ENGEngland North West Mixed pop 25.00.0251379See
VENVenezuela Zulia Maracaibo Mixed0.025020See
MEXMexico Sinaloa Capomos Mayo Yoremes0.025060See
MEXMexico Tabasco Rural0.0246142See
MEXMexico Tabasco, Villahermosa0.024482See
MEXMexico Morelos, Cuernavaca0.024482See
INDIndia Kerala Adiya0.024021See
PAKPakistan Brahui0.0240104See
MEXMexico Zacatecas, Zacatecas city0.023884See
MMRMyanmar Mon4.70.023464See
MEXMexico Michoacan, Morelia0.0232150See
MEXMexico Veracruz Rural0.0231539See
MEXMexico Chihuahua, Ciudad Juarez0.0231106See
DEUGermany Essen4.60.0230174See
USAUSA Caucasian Bethesda4.60.0230307See
INDIndia Kerala Kanikkar0.023022See
MEXMexico Zacatecas Rural0.0223266See
MEXMexico Tlaxcala, Tlaxcala city0.0221181See
MEXMexico Mayan Pop 30.022066See
ESPSpain Majorcans Jews0.0220103See
MEXMexico Mexico City Mestizo0.0210121See
MEXMexico Guerrero state0.0208144See
MMRMyanmar Rakhine4.20.020848See
MEXMexico Quintana Roo, Cancun0.020848See
MEXMexico Sonora, Hermosillo0.020299See
SAUSaudi Arabia pop 43.80.0201499See
MYSMalaysia Sarawak Bidayuh0.020050See
VENVenezuela Caracas Mestizo0.020050See
MEXMexico Nahuas0.020072See
BFABurkina Faso Fulani0.020049See
MEXMexico Quintana Roo Rural0.020050See
MEXMexico Baja California, Tijuana0.020025See
MEXMexico Tamaulipas Rural0.0198125See
MEXMexico Mexico City East0.018879See
SENSenegal Dakar3.60.0180112See
MEXMexico Veracruz, Coatzacoalcos0.017955See
MEXMexico Yucatan, Merida0.0179192See
MEXMexico Sonora Rural0.0178197See
MEXMexico Oaxaca Rural0.0175485See
INDIndia Bikaner Raikas3.40.0170143See
IRQIraq Arabs3.40.0168149See
MEXMexico Sinaloa Rural0.0164183See
MEXMexico Colima, Colima city0.016461See
BRABrazil Parana Oriental3.00.015033See
LKASri Lanka Colombo Sinhalese0.0150101See
MEXMexico Yucatan Rural0.0149132See
MEXMexico Campeche, Campeche city0.014734See
BGDBangladesh Dhaka Bangalee0.0140141See
MEXMexico Mexico City North0.0139751See
MEXMexico Puebla Rural0.0138833See
MEXMexico Hidalgo, Pachuca0.012241See
ARMArmenia living in Iran0.012085See
TUNTunisia Ghannouch0.012082See
RUSRussia Nenet Mixed0.012055See
MEXMexico San Luis Potosi Rural0.011587See
MMRMyanmar Kayin2.30.011444See
MNGMongolia Khalkha pop 20.0110202See
RUSRussia Murmansk Saomi Mixed0.010070See
MNGMongolia Oold0.0100104See
TTOTrinidad African0.010067See
VNMVietnam Hanoi0.010050See
INDIndia Bikaner Non-Raikas1.90.0100127See
PHLPhilippines National Capital Region0.010051See
MEXMexico Mexico City South0.009652See
MEXMexico Chiapas, Tuxtla Gutierrez0.009452See
TWNTaiwan Chinese immigrants from South China0.0090172See
IRNIran pop 10.008064See
MMRMyanmar Kachin1.60.007963See
BRABrazil Parana Japanese2.00.0078192See
BOLBolivia Quechua0.007269See
RUSRussia Transbaikal Territory Buryats1.00.0070150See
PERPeru Arequipa Mestizo1.40.0070168See
PAKPakistan Kalash0.007069See
MEXMexico Oaxaca, Oaxaca city0.0066151See
MEXMexico Hidalgo Rural0.006281See
ESPSpain Ibiza0.006088See
CHNChina Shaanxi Province Han0.006010000See
PAKPakistan Mixed Pathan0.0050100See
MNGMongolia Khalkha0.0050200See
CHNChina Guangdong Province1.00.0050403See
CHNChina Shandong Province0.80.00407418See
TWNTaiwan Minnan and Hakka0.0030190See
NORNorway Sami0.0030200See
CHNChina Jiangsu Province0.003020248See
CHNChina Shanghai0.003026266See
TWNTaiwan Chinese immigrants from North China0.0030152See
TWNTaiwan Minnan pop 20.00207137See
KORSouth Korea pop 10.0020324See
TWNTaiwan Hakka pop 20.0010714See
TWNTaiwan Aborigine0.0000111See
TWNTaiwan Chinese immigrants from Middle China0.0000211See
MEXMexico Huasteca Region Teenek0.000055See
PAKPakistan Burusho0.000092See
MNGMongolia Tsaatan0.0000144See
ARGArgentina Chiriguano0.00.000054See
ARGArgentina Salta Wichi pop 20.00.000019See
INDIndia Kerala Kurichiya0.000010See
INDIndia Kerala Kuruma0.000015See
CHNChina Harbin Manchu0.0000172See
CHNChina Harbin Korean0.0000201See
MNGMongolia Ulaanbaatar Khalkha0.000041See
JPNJapan Hyogo Osaka and Nagano0.0000195See
CHNChina North Han0.0000105See
INDIndia Kerala Hindu Ezhava0.000024See
INDIndia Kerala Malabar Muslim0.000034See
INDIndia Kerala Paniya0.000010See
INDIndia Kerala Malapandaram0.000010See
INDIndia Kerala Hindu Pulaya0.000016See
INDIndia Kerala Hindu Nair0.000041See
KORSouth Korea pop 80.00007096See
CMRCameroon Bamileke 20.000035See
MEXMexico Campeche Rural0.000047See
MEXMexico San Luis Potosi, San Luis Potosi city0.000030See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
MEXMexico Guanajuato, Guanajuato city0.000022See
ECUEcuador Amazonia Mixed Ancestry0.000039See

See also higher resolution data of this allele

Allele  Number of Populations 
 B*18:01 269 
 B*18:01:01 52 
 B*18:02 101 
 B*18:03 108 
 B*18:04 81 
 B*18:05 58 
 B*18:06 32 
 B*18:07 67 
 B*18:08 19 
 B*18:09 23 
 B*18:10 15 
 B*18:11 21 
 B*18:12 24 
 B*18:13 17 
 B*18:14 20 
 B*18:15 12 
 B*18:18 20 
 B*18:19 10 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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