Allele Frequencies in World Populations

HLA Database Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 138 time(s) and present in 119 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
GBRUnited Kingdom South West0.1411163See
GBRUnited Kingdom North0.1216330See
ENGEngland Sheffield21.80.11564755See
ENGEngland Leeds21.70.11515024See
GBRUnited Kingdom Orkney0.113688See
WALWales pop 221.30.113039979See
ENGEngland Liverpool21.30.11281343See
ENGEngland Manchester21.00.11111640See
FRAFrance Bordeaux21.30.1066990See
GBRUnited Kingdom Central0.1037135See
ENGEngland Lancaster19.60.1033545See
ENGEngland Newcastle19.40.10222739See
FRAFrance Rennes pop 420.40.10221000See
ESPSpain Majorca0.1020407See
ESPSpain Murcia19.00.1000173See
VENVenezuela Zulia Maracaibo Mixed0.100020See
FRAFrance Grenoble, Nantes and Rennes0.09906094See
ESPSpain, Castilla y Leon, Northwest,19.40.09781743See
FRAFrance Marseille18.40.09201000See
GBRUnited Kingdom East0.0890163See
CHESwitzerland Geneva0.089080See
ENGEngland North West Mixed pop 217.70.0884379See
NORNorway ethnic Norwegians16.70.08814510See
ESPSpain Ibiza0.088088See
SWESweden pop 416.20.0849966See
FRAFrance Grenoble16.80.08411000See
NORNorway pop 20.0830576See
FRAFrance Lyon16.50.08234813See
ALBAlbanian Kosovo0.0792120See
ESPSpain Galicia and Murcia15.00.0780473See
ALBAlbania pop 213.40.0732432See
CHLChile Easter Island0.071021See
PRTPortugal North pop 20.07021801See
AUTAustria Cord Bloods0.06951368See
ESPSpain Minorca0.069094See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.068096See
MKDMacedonia MBMDR - Macedonian Muslims11.80.065876See
POLPoland North12.50.064580See
ITAItaly North Pavia pop 30.0637685See
PRTAzores Terceira Island0.0620130See
RUSRussia Northwest pop 312.00.0600100See
ARGArgentina La Plata12.00.0580100See
SRBSerbia Vojvodina11.50.0570400See
DZAAlgeria pop 211.00.0566106See
TURTurkey pop 50.0560142See
ARGArgentina Buenos Aires10.10.0510466See
RUSRussia Arkhangelsk Pomor0.050063See
MEXMexico Mestizo pop 40.0496269See
SVNSlovenia pop 39.20.0470130See
POLPoland pop 39.10.04542907See
MKDMacedonia pop 40.0440216See
MEXMexico Mexico City Mestizo pop 30.0430256See
CUBCuba Mixed pop 20.0430189See
INDIndia North Gujarat8.60.0429338See
POLPoland Lower Silesia Region8.10.0410123See
ITAItaly Rome8.00.0400100See
ITAItaly East Sicily8.00.040050See
GRCGreece pop 70.039211250See
RUSRussia Moscow0.03802650See
HRVCroatia pop 37.50.0375120See
POLPoland Wroclaw7.00.0360123See
VENVenezuela Colonia Tovar0.034986See
SRBSerbia pop 36.90.03461992See
ROMRomania pop 36.90.03431469See
MKDMacedonia MBMDR - Macedonian6.80.03431283See
PERPeru Arequipa Mestizo6.80.0340168See
ITAItaly South Campania Region6.60.03351089See
SENSenegal Niokholo Mandenka0.0330165See
SDNSudan South Nuba6.50.033046See
USAUSA African American Bethesda6.40.0320187See
PAKPakistan Burusho0.031092See
PAKPakistan Mixed Pathan0.0300100See
ROMRomania pop 20.03006936See
RUSRussia Murmansk Saomi Mixed0.030070See
KURIraq Kurdistan Region4.80.0290209See
CMRCameroon Uldeme0.029035See
RUSRussia Tatars0.0281355See
MKDMacedonia MBMDR - Albanian5.50.0273128See
CMRCameroon Ewondo0.026038See
BRABrazil Curitiba-Parana Mixed0.0246264See
SAUSaudi Arabia pop 44.70.0234499See
PAKPakistan Kalash0.022069See
MEXMexico Tapachula, Chiapas Mestizo Population4.20.020872See
GRCGreece pop34.10.0207246See
BRABrazil Parana Japanese4.00.0183192See
JPNJapan Hyogo3.10.016032See
SDNSudan Khartoum0.015398See
LKASri Lanka Colombo Sinhalese0.0150101See
INDIndia North pop 20.015072See
INDIndia Kerala Malabar Muslim0.015034See
CMRCameroon Bamileke 20.014035See
PAKPakistan Brahui0.0140104See
SDNSudan Central Shaigiya Mixed2.70.013536See
IRNIran pop 40.0132855See
IRNIran Tehran0.0130120See
ITAItaly North Pavia0.012081See
GNQEquatorial Guinea Bioko Island Bubi0.0100100See
BRABrazil Pernambuco Mixed0.0100101See
TTOTrinidad South Asian0.010087See
TTOTrinidad African0.010067See
VNMVietnam Hanoi0.010050See
VENVenezuela Caracas Mestizo0.010050See
PAKPakistan Mixed Sindhi0.0100101See
MNGMongolia Khalkha0.0100200See
NORNorway Sami0.0080200See
MMRMyanmar Kachin1.60.007963See
MNGMongolia Tsaatan0.0070144See
CHNChina Shandong Province Linqu County1.40.0070139See
ESPSpain Majorcans Jews0.0070103See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.005094See
PAKPakistan Karachi Parsi0.005091See
JPNJapan pop 20.0020916See
INDIndia Kerala Hindu Namboothiri0.000040See
INDIndia Kerala Paniya0.000010See
INDIndia Kerala Malapandaram0.000010See
INDIndia Kerala Adiya0.000021See
INDIndia Kerala Kurichiya0.000010See
INDIndia Kerala Kanikkar0.000022See
INDIndia Kerala Kattunaikka0.000017See
INDIndia Kerala Kuruma0.000015See
INDIndia Kerala Hindu Pulaya0.000016See
INDIndia Kerala Hindu Nair0.000041See
INDIndia Kerala Syrian Christian0.000031See
INDIndia Kerala Hindu Ezhava0.000024See
CHNChina North Han0.0000105See
CMRCameroon Podokwo0.000043See
PAKPakistan Baloch0.000066See
RUSRussia Nenet Mixed0.000055See
MYSMalaysia Negeri Sembilan Minangkabau0.000034See
MYSMalaysia Perak Rawa0.000023See
MNGMongolia Oold0.0000104See

See also higher resolution data of this allele

Allele  Number of Populations 
 C*05:01 213 
 C*05:01:01 45 
 C*05:03 16 
 C*05:04 36 
 C*05:05 15 
 C*05:06 11 
 C*05:07N 17 
 C*05:08 16 
 C*05:09 50 
 C*05:14 15 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.

Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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