Allele Frequencies in World Populations

HLA Database Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 122 time(s) and present in 105 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
VENVenezuela Zulia San Jose de Heras Mixed0.175020See
CMRCameroon Uldeme0.157035See
SDNSudan Central Shaigiya Mixed22.20.117936See
ESPSpain Ibiza0.114088See
CMRCameroon Podokwo0.105043See
ESPSpain Majorcans Jews0.1000103See
KURIraq Kurdistan Region18.70.0980209See
TTOTrinidad African0.090067See
ESPSpain Galicia and Murcia16.10.0840473See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.083096See
ESPSpain, Castilla y Leon, Northwest,17.30.08221743See
ESPSpain Murcia15.00.0780173See
ARGArgentina Buenos Aires14.30.0740466See
FRAFrance Bordeaux14.50.0723990See
MEXMexico Mestizo pop 40.0714269See
IRQIraq Erbil13.40.0701372See
ESPSpain Minorca0.069094See
FRAFrance Lyon13.40.06734813See
USAUSA African American Bethesda11.70.0640187See
SAUSaudi Arabia pop 412.00.0619499See
PRTPortugal North pop 20.06071801See
FRAFrance Marseille11.90.05931000See
FRAFrance Rennes pop 411.70.05871000See
GBRUnited Kingdom East0.0583163See
VENVenezuela Colonia Tovar0.058186See
IRNIran pop 40.0573855See
INDIndia North Gujarat11.40.0571338See
GBRUnited Kingdom Orkney0.056888See
FRAFrance Grenoble11.10.05541000See
FRAFrance Grenoble, Nantes and Rennes0.05506094See
PAKPakistan Mixed Pathan0.0550100See
ENGEngland Manchester10.50.05391640See
ESPSpain Majorca0.0510407See
CUBCuba Mixed pop 20.0510189See
BRABrazil Pernambuco Mixed0.0500101See
VENVenezuela Zulia Maracaibo Mixed0.050020See
ENGEngland Lancaster9.60.0492545See
ENGEngland Leeds9.40.04815024See
ENGEngland Liverpool9.20.04711343See
ENGEngland Sheffield9.10.04654755See
WALWales pop 28.90.046039979See
POLPoland Wroclaw9.00.0460123See
POLPoland Lower Silesia Region8.90.0450123See
ENGEngland Newcastle8.80.04502739See
SDNSudan South Nuba8.70.044446See
ARGArgentina La Plata9.00.0430100See
ITAItaly North Pavia pop 30.0424685See
ENGEngland North West Mixed pop 28.40.0422379See
INDIndia Kerala Hindu Ezhava0.042024See
GBRUnited Kingdom North0.0405330See
ITAItaly East Sicily8.00.040050See
CMRCameroon Ewondo0.040038See
GRCGreece pop 70.035811250See
ITAItaly Rome7.00.0350100See
PRTAzores Terceira Island0.0350130See
PAKPakistan Mixed Sindhi0.0340101See
BRABrazil Curitiba-Parana Mixed0.0335264See
ROMRomania pop 20.03006936See
GBRUnited Kingdom Central0.0296135See
INDIndia Kerala Malabar Muslim0.029034See
CMRCameroon Bamileke 20.029035See
PAKPakistan Kalash0.029069See
MNGMongolia Oold0.0290104See
ALBAlbania pop 25.70.0287432See
POLPoland North5.00.025380See
ITAItaly North Pavia0.025081See
LKASri Lanka Colombo Sinhalese0.0250101See
SVNSlovenia pop 34.60.0230130See
GRCGreece pop34.50.0227246See
NORNorway ethnic Norwegians4.40.02244510See
SWESweden pop 44.40.0223966See
GBRUnited Kingdom South West0.0215163See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.021094See
MYSMalaysia Perak Rawa0.020023See
NORNorway pop 20.0200576See
PAKPakistan Burusho0.020092See
PERPeru Arequipa Mestizo4.10.0200168See
VENVenezuela Caracas Mestizo0.020050See
ROMRomania pop 33.90.01961469See
MKDMacedonia MBMDR - Macedonian3.70.01871283See
POLPoland pop 33.70.01872907See
RUSRussia Moscow0.01702650See
HRVCroatia pop 33.30.0167120See
INDIndia Kerala Syrian Christian0.016031See
MEXMexico Mexico City Mestizo pop 30.0160256See
RUSRussia Northwest pop 32.00.0150100See
RUSRussia Tatars0.0140355See
CZECzech Republic0.0140106See
SRBSerbia Vojvodina2.70.0130400See
ALBAlbanian Kosovo0.0125120See
MKDMacedonia pop 40.0090216See
MKDMacedonia MBMDR - Albanian1.60.0078128See
MKDMacedonia MBMDR - Macedonian Muslims1.30.006676See
BRABrazil Parana Japanese1.00.0053192See
MNGMongolia Khalkha0.0050200See
PAKPakistan Brahui0.0050104See
SRBSerbia pop 30.60.00321992See
RUSRussia Nenet Mixed0.000055See
RUSRussia Murmansk Saomi Mixed0.000070See
NORNorway Sami0.0000200See
MYSMalaysia Negeri Sembilan Minangkabau0.000034See
MNGMongolia Tsaatan0.0000144See
VNMVietnam Hanoi0.000050See
INDIndia Kerala Paniya0.000010See
INDIndia Kerala Malapandaram0.000010See
INDIndia Kerala Adiya0.000021See
INDIndia Kerala Kurichiya0.000010See
INDIndia Kerala Kanikkar0.000022See
INDIndia Kerala Kattunaikka0.000017See
INDIndia Kerala Hindu Namboothiri0.000040See
INDIndia Kerala Kuruma0.000015See
INDIndia Kerala Hindu Pulaya0.000016See
INDIndia Kerala Hindu Nair0.000041See
CHNChina North Han0.0000105See

See also higher resolution data of this allele

Allele  Number of Populations 
 C*16:01 202 
 C*16:01:01 35 
 C*16:02 197 
 C*16:02:01 26 
 C*16:04 101 
 C*16:04:01 40 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.

Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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