Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 292 time(s) and present in 223 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
BFABurkina Faso Rimaibe0.138047See
GNBGuinea Bissau0.108065See
CMRCameroon Baka Pygmy0.100010See
ZAFSouth Africa Natal Zulu18.00.0950100See
KENKenya Luo0.0890265See
UGAUganda Kampala pop 20.0860175See
ZAFSouth Africa Black0.0840200See
CIVIvory Coast Adiopodoume Akan0.080044See
KENKenya Nandi0.0790240See
ZWEZimbabwe Harare Shona0.0770230See
CMRCameroon Sawa0.077013See
USAUSA African American0.0740252See
BFABurkina Faso Fulani0.071049See
USAUSA African American pop 80.0710605See
MLIMali Bandiagara0.0690138See
SENSenegal Niokholo Mandenka0.0690165See
CPVCape Verde Southeastern Islands0.065062See
USAUSA NMDP African American pop 20.0640416581See
USAUSA NMDP African0.063028557See
STPSao Tome Island Angolar0.063032See
USAUSA African American pop 40.06252411See
UGAUganda Kampala0.0620161See
ISRIsrael Ethiopia Jews0.06035928See
SDNSudan Mixed11.50.0600200See
KENKenya, Nyanza Province, Luo tribe10.00.0600100See
USAUSA African American Bethesda11.70.0580187See
ZMBZambia Lusaka0.057044See
ZAFSouth Africa Worcester11.00.0570159See
USAUSA NMDP Caribean Black0.055533328See
USAUSA African American pop 30.0500564See
CMRCameroon Yaounde0.049092See
CPVCape Verde Northwestern Islands0.048062See
MEXMexico Sonora, Hermosillo0.045599See
TUNTunisia pop 30.0450104See
STPSao Tome Island Forro0.045066See
CMRCameroon Bamileke0.045077See
CMRCameroon Beti0.0370174See
MEXMexico Zacatecas Rural0.0335266See
MEXMexico San Luis Potosi, San Luis Potosi city0.033330See
BRABrazil Belo Horizonte Caucasian6.30.032095See
TUNTunisia Gabes0.031595See
MEXMexico Sonora, Ciudad Obregón0.0315143See
GHAGhana Ga-Adangbe6.10.0305131See
ECUEcuador Coast Mixed Ancestry0.0252238See
PRTAzores Terceira Island0.0240130See
USAUSA NMDP Caribean Indian0.024014339See
MEXMexico Nayarit Rural0.023464See
MEXMexico Coahuila, Torreon0.0225396See
USAUSA Spain Ancestry0.0220279See
PRTPortugal Azores Terceira Island4.40.0219130See
CHESwitzerland Geneva pop 20.02021267See
SAUSaudi Arabia Guraiat and Hail3.40.0200213See
MEXMexico Baja California, La Paz0.020075See
USAUSA NMDP Caribean Hispanic0.0200115374See
CHESwitzerland Sion0.0193832See
AREUnited Arab Emirates Abu Dhabi0.019252See
SDNSudan East Rashaida3.70.018627See
MEXMexico Veracruz3.60.017984See
MEXMexico Veracruz, Cordoba0.017956See
USAUSA South Texas Hispanic0.0170194See
USAUSA Hispanic0.0170234See
MEXMexico Chihuahua, Chihuahua city0.0168119See
USAUSA Hispanic pop 20.01601999See
MEXMexico Sonora Rural0.0152197See
MEXMexico Baja Californa, Mexicali0.0150100See
AREUnited Arab Emirates pop 22.90.0150373See
MEXMexico Veracruz, Veracruz city0.0145171See
MEXMexico Jalisco, Tonala0.014335See
MEXMexico Michoacan Rural0.0143348See
BRABrazil Mixed0.0140108See
MARMorocco Nador Metalsa pop 20.014073See
CUBCuba Caucasian2.90.014070See
MEXMexico Coahuila Rural0.0138216See
MEXMexico Coahuila, Saltillo0.013772See
NICNicaragua Managua2.70.0136339See
MEXMexico Michoacan, Morelia0.0132150See
MEXMexico Mexico City Center0.0130152See
USAUSA NMDP Hispanic South or Central American0.0129146714See
ECUEcuador Amazonia Mixed Ancestry0.012839See
MEXMexico Mestizo2.40.012041See
MEXMexico Zacatecas, Zacatecas city0.011984See
CHESwitzerland Lugano0.01151169See
MEXMexico Jalisco, Guadalajara city0.01131189See
USAUSA San Diego2.20.0110496See
PRTPortugal North0.011046See
ITAItaly Bergamo2.00.0110101See
MEXMexico Tabasco Rural0.0106142See
COLColombia North Chimila Amerindians0.010647See
MEXMexico Nayarit, Tepic0.010397See
COLColombia Bogotá Cord Blood2.10.01031463See
MEXMexico Veracruz Rural0.0102539See
USAUSA NMDP Mexican or Chicano0.0101261235See
MEXMexico Guadalajara Mestizo pop 20.0100103See
IRNIran Baloch0.0100100See
ASMAmerican Samoa0.010051See
CHESwitzerland St Gallen0.00962113See
MEXMexico Zacatecas, Fresnillo0.0095103See
MEXMexico Chihuahua, Ciudad Juarez0.0093106See
MEXMexico Nuevo Leon Rural0.0091439See
ISRIsrael Ashkenazi and Non Ashkenazi Jews0.0090146See
TWNTaiwan Hakka1.80.009055See
USAUSA Mexican American Mestizo0.0090553See
PRTAzores Central Islands0.009059See
ECUEcuador Mixed Ancestry0.00901173See
MEXMexico Veracruz, Coatzacoalcos0.008955See
MEXMexico Tamaulipas Rural0.0079125See
MEXMexico Yucatan, Merida0.0077192See
MEXMexico Durango Rural0.0076326See
ITAItaly pop 50.0070975See
MARMorocco Settat Chaouya1.40.007098See
MARMorocco Atlantic Coast Chaouya0.007098See
CHLChile Mapuches0.0070104See
MEXMexico Oaxaca, Oaxaca city0.0066151See
MEXMexico Guanajuato, Leon0.006478See
CHESwitzerland Aargau-Solothurn0.00641838See
MEXMexico Mexico City East0.006379See
DEUGermany DKMS - Portugal minority0.00641176See
MEXMexico Tabasco, Villahermosa0.006182See
MEXMexico Mexico City1.20.0061330See
MEXMexico Mexico City North0.0060751See
ESPSpain Andalusia0.006099See
ITAItaly North Pavia0.006081See
DEUGermany DKMS - Spain minority0.00591107See
MEXMexico Chihuahua Chihuahua1.10.005788See
CHESwitzerland Zurich0.00574875See
ISRIsrael Arab pop 20.005712301See
DEUGermany DKMS - Italy minority0.00561159See
MEXMexico Sinaloa Rural0.0055183See
ISRIsrael Kavkazi Jews0.00532840See
MEXMexico Jalisco Rural0.0051585See
MEXMexico Oaxaca Rural0.0051485See
USAUSA NMDP Middle Eastern or North Coast of Africa0.005170890See
ZAFSouth Africa Caucasians0.0050102See
USAUSA NMDP American Indian South or Central America0.00505926See
CHLChile Santiago Mixed1.00.005070See
CHESwitzerland Luzern0.00491553See
MEXMexico Nuevo Leon, Monterrey city0.0044226See
MEXMexico Mexico City Mestizo pop 20.0043234See
ECUEcuador Andes Mixed Ancestry0.0042824See
AUSAustralia New South Wales Caucasian0.0040134See
FRAFrance Southeast0.80.0040130See
USAUSA Eastern European0.0040558See
MEXMexico Puebla, Puebla city0.00381994See
MEXMexico Yucatan Rural0.0037132See
CHNChina Beijing pop 20.0037826See
ISRIsrael Tunisia Jews0.00349070See
CHESwitzerland Bern0.00343545See
MEXMexico Mexico City Metropolitan Area Rural0.0033150See
ISRIsrael Morocco Jews0.003336718See
MEXMexico Durango, Durango city0.0032153See
USAUSA NMDP North American Amerindian0.003235791See
MEXMexico Guanajuato Rural0.0031162See
MEXMexico Jalisco, Zapopan0.0030168See
ENGEngland North West0.70.0030298See
RUSRussia Tuva pop 20.0030169See
CHESwitzerland Lausanne0.0030993See
USAUSA San Antonio Caucasian0.0030222See
USAUSA North American Native0.0030187See
DEUGermany DKMS - Netherlands minority0.00291374See
MEXMexico Tlaxcala, Tlaxcala city0.0028181See
MEXMexico Veracruz, Xalapa0.0027187See
MYSMalaysia Peninsular Chinese0.50.0026194See
GRCGreece pop 60.0024242See
MEXMexico Chihuahua Rural0.0021236See
DEUGermany DKMS - Austria minority0.00211698See
TWNTaiwan Han Chinese0.0020504See
CHNChina Canton Han0.0020264See
USAUSA European American pop 20.00201245See
NLDNetherlands Leiden0.00201305See
USAUSA Italy Ancestry0.0020273See
MEXMexico Puebla Rural0.0018833See
DEUGermany pop 80.001639689See
DEUGermany DKMS - France minority0.00151406See
HRVCroatia pop 40.00144000See
USAUSA NMDP European Caucasian0.00141242890See
USAUSA NMDP Hawaiian or other Pacific Islander0.001311499See
DEUGermany DKMS - United Kingdom minority0.00121043See
MEXMexico Tlaxcala Rural0.0012830See
DEUGermany DKMS - Turkey minority0.00104856See
TWNTaiwan Tzu Chi Cord Blood Bank0.0010710See
CHNChina Beijing Shijiazhuang Tianjian Han0.0010618See
USAUSA NMDP Alaska Native or Aleut0.00101376See
NIRIreland Northern0.20.00101000See
ISRIsrael YemenJews0.000915542See
CZECzech Republic NMDR0.00095099See
USAUSA Caucasian pop 40.00091070See
HKGHong Kong Chinese BMDR0.00097595See
ISRIsrael Iraq Jews0.000813270See
DEUGermany DKMS - Romania minority0.00081234See
TWNTaiwan Tzu Chi Morrow Donor Registry0.000746682See
USAUSA NMDP Chinese0.000799672See
ISRIsrael Libya Jews0.00073739See
ISRIsrael Poland Jews0.000613871See
DEUGermany pop 60.00078862See
ISRIsrael Ashkenazi Jews pop 30.00054625See
HKGHong Kong Chinese cord blood registry0.00053892See
DEUGermany DKMS - Greece minority0.00051894See
DEUGermany DKMS - Croatia minority0.00052057See
POLPoland DKMS0.000620653See
ISRIsrael USA Jews0.00056058See
ISRIsrael Argentina Jews0.00054307See
INDIndia Tamil Nadu0.00052492See
USAUSA NMDP Filipino0.000450614See
ISRIsrael Druze0.00045914See
ISRIsrael Iran Jews0.00048153See
USAUSA NMDP Southeast Asian0.000327978See
CHNChina Jiangsu Han0.00033238See
DEUGermany DKMS - China minority0.00041282See
ISRIsrael USSR Jews0.000245681See
USAUSA NMDP South Asian Indian0.0002185391See
ISRIsrael Georgia Jews0.00024471See
USAUSA Asian pop 20.00031772See
USAUSA NMDP Vietnamese0.000243540See
USAUSA NMDP Japanese0.000124582See
USAUSA NMDP Korean0.000177584See
AUSAustralia Yuendumu Aborigine0.0000191See
USAUSA Caucasian Bethesda0.00.0000307See
USAUSA Asian0.0000358See
USAUSA Caucasian pop 20.0000265See
USAUSA Alaska Yupik0.0000252See
CZECzech Republic0.0000106See
KORSouth Korea pop 30.0000485See
KORSouth Korea pop 80.00007096See
USAUSA Philadelphia Caucasian0.00.0000141See
CHNChina North Han0.0000105See
PRTAzores Oriental Islands0.000043See
BRABrazil Vale do Ribeira Quilombos0.10.0000144See
CHESwitzerland Basel0.00001888See
CHESwitzerland Graubunden0.0000759See
TWNTaiwan Minnan pop 10.00.0000102See
CUBCuba Mulatto0.00.000042See
TWNTaiwan Atayal0.00.0000106See
TWNTaiwan Taroko0.00.000055See
TWNTaiwan Saisiat0.00.000051See
TWNTaiwan Bunun0.00.0000101See
TWNTaiwan Tsou0.00.000051See
TWNTaiwan Rukai0.00.000050See
TWNTaiwan Paiwan0.00.000051See
TWNTaiwan Ami0.00.000098See
TWNTaiwan Puyuma0.00.000050See
TWNTaiwan Tao0.00.000050See
TWNTaiwan Pazeh0.00.000055See
TWNTaiwan Siraya0.00.000051See
TWNTaiwan Thao0.00.000030See
PHLPhilippines Ivatan0.00.000050See
SGPSingapore Chinese0.00.0000149See
PRTPortugal Center0.000050See
PRTPortugal South0.000049See
INDIndia Mumbai Maratha0.000091See
HKGHong Kong Chinese0.00.0000569See
CHNChina Tibet Region Tibetan0.0000158See
MEXMexico Mexico City Mestizo0.0000121See
MEXMexico Puebla Mestizo0.000099See
MEXMexico Sinaloa Mestizo0.000056See
TWNTaiwan Tzu Chi Morrow Donor Registry Aborigine0.0000233See
MEXMexico Aguascalientes state0.000095See
MEXMexico Mexico City West0.000033See
MEXMexico Quintana Roo, Cancun0.000048See
MEXMexico Baja California Rural0.000050See
MEXMexico Colima Rural0.000043See
MEXMexico Guerrero state0.0000144See
MEXMexico Morelos, Cuernavaca0.000082See
MEXMexico Chiapas, Tuxtla Gutierrez0.000052See
MEXMexico Campeche, Campeche city0.000034See
MEXMexico Hidalgo Rural0.000081See
MEXMexico San Luis Potosi Rural0.000087See
MEXMexico Queretaro Rural0.000043See
MEXMexico Morelos Rural0.000030See
MEXMexico Baja California, Tijuana0.000025See
MEXMexico Quintana Roo Rural0.000050See
MEXMexico Sinaloa, Culiacán0.0000103See
MEXMexico Chiapas Rural0.0000121See
MEXMexico Campeche Rural0.000047See
MEXMexico Jalisco, Tlaquepaque0.000039See
MEXMexico Jalisco, Tlajomulco0.000030See
MEXMexico Veracruz, Poza Rica0.000045See
MEXMexico Hidalgo, Pachuca0.000041See
MEXMexico Mexico City South0.000052See
MEXMexico Colima, Colima city0.000061See
MEXMexico Veracruz, Orizaba0.000060See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
MEXMexico Queretaro, Queretaro city0.000045See
MEXMexico Guanajuato, Guanajuato city0.000022See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

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