Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 235 time(s) and present in 185 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
SDNSudan Mixed21.50.1200200See
PERPeru Lamas City Lama0.096083See
BRABrazil East Amazon0.085041See
ETHEthiopia Amhara0.082098See
BRABrazil Guarani M bya0.081093See
STPSao Tome Island Angolar0.063032See
ISRIsrael Ethiopia Jews0.06275928See
COLColombia San Basilio de Palenque0.060042See
USAUSA NMDP African0.057928557See
USAUSA NMDP Caribean Black0.057033328See
TZATanzania Maasai11.00.0566336See
CODCongo Kinshasa Bantu11.10.056090See
USAUSA NMDP African American pop 20.0542416581See
USAUSA African American pop 40.05052411See
ZWEZimbabwe Harare Shona0.0460230See
BRABrazil Guarani Nandeva0.046086See
ETHEthiopia Oromo0.042083See
USAUSA African American pop 70.0410193See
GMBGambia pop 37.40.0382939See
USAUSA Colorado Univ Cord Blood Bank African American0.0370261See
BRABrazil Southeast Mixed Race7.10.036042See
USAUSA African American Bethesda7.00.0350187See
KENKenya, Nyanza Province, Luo tribe7.00.0350100See
USAUSA Southern California Mestizo6.80.034673See
RWARwanda Kigali Hutu and Tutsi0.0340281See
SENSenegal Dakar6.70.0330112See
USAUSA NMDP North American Amerindian0.030735791See
MEXMexico Mazahua0.030065See
MEXMexico Jaltepec Mazahuas0.030050See
BRABrazil Mixed0.0300108See
SAUSaudi Arabia Guraiat and Hail4.40.0270213See
TUNTunisia Jerba Berber0.027055See
ARGArgentina Chiriguano5.40.027054See
ARGArgentina Salta Wichi pop 25.30.026019See
ITAItaly Rome5.00.0250100See
BRABrazil North East Mixed0.0250205See
TUNTunisia Matmata Berber0.025081See
ISRIsrael Arab pop 20.024612301See
CUBCuba Mixed0.023078See
COLColombia North Chimila Amerindians0.021247See
AREUnited Arab Emirates Abu Dhabi0.019252See
USAUSA NMDP Alaska Native or Aleut0.01801376See
HRVCroatia Krk Island Vrbnik0.018028See
BRABrazil Terena3.40.017060See
USAUSA NMDP Caribean Hispanic0.0164115374See
USAUSA NMDP Caribean Indian0.016014339See
ZAFSouth Africa Worcester3.00.0160159See
TUNTunisia Gabes Arab0.016096See
SWESweden Northern Sami0.0160154See
TUNTunisia Gabes0.015795See
BOLBolivia Quechua0.014569See
USAUSA NMDP American Indian South or Central America0.01405926See
RUSRussia Siberia Ulchi0.014073See
MEXMexico Nahua/Aztec Santo Domingo Ocotitlan0.013773See
SAUSaudi Arabia pop 6 (G)0.013528927See
ISRIsrael Non Ashkenazi Jews0.013080See
BRABrazil Paraná Caucasian2.50.0125641See
USAUSA Caucasian Bethesda2.40.0120307See
USAUSA Caucasian Pittsburgh2.40.0120177See
USAUSA Colorado Univ Cord Blood Bank Hispanic0.01201058See
JPNJapan pop 62.30.0115129See
USAUSA Hispanic pop 20.01131999See
LBNLebanon Kafar Zubian0.011094See
ZAFSouth Africa Caucasians0.0110102See
CHNChina, Xinjiang Uyghur Autonomous Region Uyghur2.20.010971See
ISRIsrael YemenJews0.010615542See
MEXMexico Mexico City Mestizo population0.0105143See
COLColombia Bogotá Cord Blood2.10.01031463See
BRABrazil Puyanawa2.00.0100150See
PRTPortugal South0.010049See
ARGArgentina Buenos Aires1.90.0100466See
USAUSA Caucasian Houston2.00.0100194See
BRABrazil Southeast Caucasian1.90.0100103See
DZAAlgeria pop 22.00.0100106See
USAUSA NMDP Hispanic South or Central American0.0094146714See
USAUSA Mexican American Mestizo pop 30.0090116See
COLColombia Guajira Peninsula Wayuu0.009088See
USAUSA NMDP Middle Eastern or North Coast of Africa0.008470890See
ISRIsrael Druze0.00845914See
STPSao Tome Island Forro0.008066See
BRABrazil Mato Grosso do Sul0.0070203See
USAUSA NMDP Mexican or Chicano0.0068261235See
DEUGermany DKMS - Italy minority0.00671159See
GRCGreece pop 60.0062242See
GRCGreece pop 81.20.006083See
PRTMadeira pop 20.0060173See
ISRIsrael Ashkenazi Jews0.006080See
DEUGermany Essen1.20.0060174See
NICNicaragua Managua1.20.0060339See
BOLBolivia La Paz Aymaras0.006087See
MEXMexico Chihuahua Chihuahua City Pop 21.10.005788See
ISRIsrael Libya Jews0.00523739See
ARMArmenia combined Regions0.0050100See
CZECzech Republic0.0050106See
MNGMongolia Khalkha0.0050200See
USAUSA Colorado Univ Cord Blood Bank Asian0.0050100See
ITAItaly North pop 31.10.005097See
RUSRussia Tuva0.0050190See
USAUSA San Francisco Caucasian0.0050220See
CHNChina Beijing Shijiazhuang Tianjian Han0.0050618See
TUNTunisia pop 30.0050104See
IRNIran Azeri0.0050100See
HRVCroatia Krk Island0.0050212See
DEUGermany DKMS - Turkey minority0.00474856See
DEUGermany pop 30.90.0045111See
PRTPortugal Azores Terceira Island0.90.0044130See
MEXMexico Mexico City Mestizo pop 20.0043234See
GEOGeorgia Caucasus Tbilisi0.0042119See
ITAItaly pop 50.0040975See
SWESweden Southern Sami0.0040130See
GTMGuatemala Mayan0.0040132See
PRTAzores Terceira Island0.0040130See
ESPSpain Murcia0.0040173See
CHLChile Santiago0.0038920See
DEUGermany DKMS - Bosnia and Herzegovina minority0.00391028See
DEUGermany DKMS - Portugal minority0.00381176See
SVNSlovenia pop 20.70.0035140See
ISRIsrael Iraq Jews0.003213270See
HRVCroatia pop 40.00324000See
GAZGaza Palestinians0.0030165See
FINFinland pop20.0030150See
RUSRussia Transbaikal Territory Buryats1.00.0030150See
DEUGermany pop 80.003039689See
BRABrazil Guarani Kaiowa0.0030155See
ITAItaly Central0.0030380See
MKDMacedonia pop 10.0030158See
MKDMacedonia pop 30.0030172See
USAUSA Caucasian pop 40.00291070See
DEUGermany DKMS - Spain minority0.00271107See
DEUGermany DKMS - Croatia minority0.00272057See
DEUGermany DKMS - United Kingdom minority0.00241043See
DEUGermany DKMS - German donors0.00233456066See
ESPSpain (Catalunya, Navarra, Extremadura, Aaragón, Cantabria,0.40.00224335See
DEUGermany DKMS - Netherlands minority0.00221374See
DEUGermany DKMS - France minority0.00211406See
DEUGermany DKMS - Austria minority0.00211698See
GRCGreece pop30.40.0020246See
USAUSA Alaska Yupik0.0020252See
USAUSA Colorado Univ Cord Blood Bank Caucasian0.00203830See
ESPSpain Barcelona0.40.0020941See
USAUSA San Diego0.40.0020496See
NLDNetherlands Leiden0.00201305See
USAUSA NMDP European Caucasian0.00201242890See
MYSMalaysia Peninsular Indian0.40.0018271See
DEUGermany pop 60.00188862See
CHNChina Jiangsu Province Han0.0018334See
CZECzech Republic NMDR0.00175099See
MEXMexico Mexico City Tlalpan0.30.0015330See
DEUGermany DKMS - Greece minority0.00161894See
POLPoland DKMS0.001420653See
ISRIsrael Morocco Jews0.001336718See
DEUGermany DKMS - Romania minority0.00121234See
USAUSA NMDP Southeast Asian0.001227978See
CHNChina Jiangsu Han0.00103238See
USAUSA Eastern European0.0010558See
RUSRussia Karelia0.00091075See
ISRIsrael Argentina Jews0.00094307See
USAUSA NMDP South Asian Indian0.0008185391See
ISRIsrael USA Jews0.00086058See
INDIndia Tamil Nadu0.00082492See
ISRIsrael Tunisia Jews0.00079070See
ISRIsrael Kavkazi Jews0.00072840See
USAUSA NMDP Hawaiian or other Pacific Islander0.000611499See
HKGHong Kong Chinese cord blood registry0.00053892See
ISRIsrael Poland Jews0.000413871See
CHNChina Hubei Han0.10.00033732See
USAUSA NMDP Vietnamese0.000343540See
ISRIsrael USSR Jews0.000245681See
USAUSA NMDP Filipino0.000250614See
ISRIsrael Bukhara Jews0.00022317See
USAUSA NMDP Japanese0.000224582See
USAUSA NMDP Chinese0.000199672See
ISRIsrael Georgia Jews0.00014471See
KORSouth Korea pop 100.00014128See
HKGHong Kong Chinese BMDR0.00017595See
USAUSA NMDP Korean0.000077584See
BRABrazil Vale do Ribeira Quilombos0.10.0000144See
BRABrazil South Caucasian0.000073See
CZECzech Republic pop 20.00.000099See
CZECzech Republic Romani0.00.000034See
FRAFrance Rennes pop 30.0000200See
GRCGreece pop 40.000098See
INDIndia North0.00.000085See
IRNIran Kurd0.0000100See
USAUSA Asian pop 20.00001772See
FRAFrance Rennes0.0000200See
LBNLebanon Niha el Shouff0.000061See
LBNLebanon Yuhmur0.000082See
MEXMexico Highlands Mestizos0.00.0000160See
MEXMexico Nuevo Leon Mestizo0.00.000040See
ARGArgentina Rio Negro Mapuche0.000034See
ARGArgentina Chubut Tehuelche0.000023See
ARGArgentina Salta Wichi0.000024See
PRYParaguay Lengua0.000017See
CANCanada British Columbia Athabaskan0.000062See
CANCanada British Columbia Penutian0.000026See
PRTPortugal North0.000046See
PRTPortugal Center0.000050See
ITAItaly Bergamo0.00.0000101See
USAUSA Caucasian0.00.000061655See
USAUSA San Antonio Caucasian0.0000222See
USAUSA South Texas Hispanic0.0000194See
KORSouth Korea pop 20.00.0000207See
BRABrazil Kaingang0.0000235See
MNGMongolia Oold0.0000104See
MNGMongolia Tsaatan0.0000144See
USAUSA Philadelphia Caucasian0.00.0000141See
RUSRussia Tuva pop30.000044See
RUSRussia Tuva Todja0.000022See
RUSRussia Siberia Irkutsk Tofalar0.000043See
RUSRussia Siberia Kushun Buryat0.000025See
RUSRussia Siberia Khanty Mansi0.000068See
RUSRussia Siberia Negidal0.000035See
RUSRussia Siberia Khabarovsk Evenki0.000025See
CHNChina Urumqi Uyghur0.00.000057See
BRABrazil Central Plateau Xavante0.000074See
ARGArgentina Gran Chaco Eastern Toba0.0000135See
ARGArgentina Gran Chaco Mataco Wichi0.000049See
ARGArgentina Gran Chaco Western Toba Pilaga0.000019See
PRYParaguay Aché0.000087See
PERPeru Quechua0.000044See
ISRIsrael Moroccan Jews0.0000113See
ISRIsrael Ashkenazi Jews pop 20.0000132See
FRAFrance West0.00.0000100See
CAFCentral African Republic Aka Pygmy0.00.000093See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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