Allele Frequencies in World Populations
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line PMID Authors Year Article title Journal Volume
111034591O'Donohue et al.2000Co-amoxiclav jaundice: clinical and histological features and HLA class II association.Gut47
211146763Dettling et al.2001Genetic determinants of clozapine-induced agranulocytosis: recent results of HLA subtyping in a non-jewish caucasian sample.Archives of general psychiatry58
311266078Dettling et al.2001Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry.Pharmacogenetics11
411888582Mallal et al.2002Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.Lancet (London, England)359
515007363Choi et al.2004HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population.The Journal of allergy and clinical immunology113
615024131Martin et al.2004Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant.Proceedings of the National Academy of Sciences of the United States of America101
715057820Chung et al.2004Medical genetics: a marker for Stevens-Johnson syndrome.Nature428
815247625Hughes et al.2004Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.Pharmacogenetics14
915743917Hung et al.2005HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.Proceedings of the National Academy of Sciences of the United States of America102
1015784113Kim et al.2005The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology35
1116538176Hung et al.2006Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.Pharmacogenetics and genomics16
1216816555Stekler et al.2006Abacavir hypersensitivity reaction in primary HIV infection.AIDS (London, England)20
1316868443Littera et al.2006HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients.AIDS (London, England)20
1416981842Alfirevic et al.2006HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.Pharmacogenomics7
1517339877Hirata et al.2008Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study.The pharmacogenomics journal8
1617505501Kindmark et al.2008Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis.The pharmacogenomics journal8
1717509004Man et al.2007Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.Epilepsia48
1818184080Rodríguez-Nóvoa et al.2007Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.AIDS research and human retroviruses23
1918192896Lonjou et al.2008A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs.Pharmacogenetics and genomics18
2018505179Almeida et al.2008Cytokine profiling in abacavir hypersensitivity patients.Antiviral therapy13
2118637831Locharernkul et al.2008Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.Epilepsia49
2219017052Kashiwagi et al.2008Human leukocyte antigen genotypes in carbamazepine-induced severe cutaneous adverse drug response in Japanese patients.The Journal of dermatology35
2319018717Kaniwa et al.2008HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.Pharmacogenomics9
2419104471Chantarangsu et al.2009HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients.Pharmacogenetics and genomics19
2519195327Rauch et al.2008Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort Study.Antiviral therapy13
2619374512Alfirevic et al.2009TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.Pharmacogenomics10
2719392989Lee et al.2009The HLA allele marker for differentiating ASA hypersensitivity phenotypes.Allergy64
2819483685Daly et al.2009HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.Nature genetics41
2919668019Kazeem et al.2009High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients.Pharmacogenetics and genomics19
3019696695Tassaneeyakul et al.2009Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population.Pharmacogenetics and genomics19
3119915237Mehta et al.Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.Indian journal of dermatology, venereology and leprology75
3220235791Hung et al.2010Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.Pharmacogenomics11
3320345939Tassaneeyakul et al.2010Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population.Epilepsia51
3420639878Singer et al.2010A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.Nature genetics42
3520833111Wu et al.2010Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China.Epilepsy & behavior : E&B19
3621071176An et al.2010Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population.Epilepsy research92
3721149285Ozeki et al.2011Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.Human molecular genetics20
3821169036Hu et al.2011Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population.Seizure20
3921204807Kaniwa et al.2010HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.Epilepsia51
4021244392Chang et al.2011Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population.International journal of dermatology50
4121245432Spraggs et al.2011HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology29
4221301380Kang et al.2011Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans.Pharmacogenetics and genomics21
4321306565Shi et al.2011Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population.Basic & clinical pharmacology & toxicology109
4421397523Wang et al.2011Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland.Seizure20
4521424386Zhang et al.2011Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients.European journal of clinical pharmacology67
4621428769McCormack et al.2011HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.The New England journal of medicine364
4721545408Cristallo et al.2011A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis.International journal of immunogenetics38
4821570397Lucena et al.2011Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.Gastroenterology141
4921676164Kulkantrakorn et al.2012HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain.Pain practice : the official journal of World Institute of Pain12
5021917426Kim et al.2011Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans.Epilepsy research97
5122053601Then et al.2011Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients.Asian Pacific journal of allergy and immunology29
5222197535Berka et al.2012Human leukocyte antigen (HLA) and pharmacogenetics: screening for HLA-B*57:01 among human immunodeficiency virus-positive patients from southern Alberta.Human immunology73
5322211527Niihara et al.2012HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population.The Journal of dermatology39
5422348415Chiu et al.2012Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong.The British journal of dermatology167
5522348435Shi et al.2012Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502?Basic & clinical pharmacology & toxicology111
5622422616Mammen et al.2012Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy.Arthritis care & research64
5722818943He et al.2012Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: incidence, features, risk factors and relation to HLA-B alleles.Seizure21
5822909208Cao et al.2012HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese.Pharmacogenomics13
5923057547Fuerst et al.2012HLA polymorphisms influence the development of skin rash arising from treatment with EGF receptor inhibitors.Pharmacogenomics13
6023153709Kim et al.2013Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen.Tuberculosis (Edinburgh, Scotland)93
6123328091Phillips et al.2013Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.Journal of acquired immune deficiency syndromes (1999)62
6223362284Carr et al.2013Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America56
6323551241Manuyakorn et al.2013Phenobarbital-induced severe cutaneous adverse drug reactions are associated with CYP2C19*2 in Thai children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology24
6423588310Amstutz et al.2013HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children.Clinical pharmacology and therapeutics94
6523600531Gonçalo et al.2013HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population.The British journal of dermatology169
6623669020Niihara et al.2013HLA-B*58:01 strongly associates with allopurinol-induced adverse drug reactions in a Japanese sample population.Journal of dermatological science71
6723692434Cheung et al.2013HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese.Epilepsia54
6823829937Lv et al.2013The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a northern Han Chinese population.BMC neurology13
6923830818Li et al.2013Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese.Epilepsy research106
7023874514Stephens et al.2013HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity.PloS one8
7124152261Zhang et al.2013HLA-B*13:01 and the dapsone hypersensitivity syndrome.The New England journal of medicine369
7224225276Chong et al.2014Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore.Archives of disease in childhood99
7324268988Hsiao et al.2014Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations.Journal of dermatological science73
7424322785Genin et al.2014HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis.The pharmacogenomics journal14
7524394201Toh et al.2014Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study.The pharmacogenomics journal14
7624399721He et al.2013Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China.Pharmacological reports : PR65
7724687830Schaid et al.2014Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury.Journal of clinical oncology : official journal of the American Society of Clinical Oncology32
7824781922Ueta et al.2014Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.Scientific reports4
7924856347Wang et al.2014Genetic susceptibility to the cross-reactivity of aromatic antiepileptic drugs-induced cutaneous adverse reactions.Epilepsy research108
8024899791Furukawa et al.2014HLA-DRB1*08:02 Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients.Biomarker insights9
8125099678Ueta et al.2014Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications.Scientific reports4
8225266342Khor et al.2014HLA-B*15:02 association with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in an Indian population: a pooled-data analysis and meta-analysis.Epilepsia55
8325303297Yang et al.2014HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population.Pharmacogenomics15
8425918017Yang et al.2016HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese.The pharmacogenomics journal16
8525938071Nguyen et al.2015HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in Vietnamese.Asia Pacific allergy5
8626086150Kongpan et al.2015Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions.Pharmacogenetics and genomics25
8726927288Chang et al.2017Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population.The pharmacogenomics journal17
8827486401Sukasem et al.2016HLA-B (*) 58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand.Frontiers in pharmacology7
8927666425Moon et al.2016HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption.Epilepsia57
Last Updated: Tuesday, June 27, 2017

Please cite this website using the following reference:
Ghattaoraya GS, Dundar Y, González-Galarza FF, Maia MH, Santos EJ, da Silva AL, McCabe A, Middleton D, Alfirevic A, Dickson R and Jones AR
A web resource for mining HLA associations with adverse drug reactions: HLA-ADR
Database (Oxford) 2016. View full article


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