Use this section to browse on the different population studies that have been included in this database.

line	PMID	Authors	Year	Article title	Journal	Volume
1	11034591	O'Donohue et al.	2000	Co-amoxiclav jaundice: clinical and histological features and HLA class II association.	Gut	47
2	11146763	Dettling et al.	2001	Genetic determinants of clozapine-induced agranulocytosis: recent results of HLA subtyping in a non-jewish caucasian sample.	Archives of general psychiatry	58
3	11266078	Dettling et al.	2001	Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry.	Pharmacogenetics	11
4	11888582	Mallal et al.	2002	Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.	Lancet (London, England)	359
5	15007363	Choi et al.	2004	HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population.	The Journal of allergy and clinical immunology	113
6	15024131	Martin et al.	2004	Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant.	Proceedings of the National Academy of Sciences of the United States of America	101
7	15057820	Chung et al.	2004	Medical genetics: a marker for Stevens-Johnson syndrome.	Nature	428
8	15247625	Hughes et al.	2004	Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.	Pharmacogenetics	14
9	15743917	Hung et al.	2005	HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.	Proceedings of the National Academy of Sciences of the United States of America	102
10	15784113	Kim et al.	2005	The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria.	Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology	35
11	16538176	Hung et al.	2006	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	Pharmacogenetics and genomics	16
12	16816555	Stekler et al.	2006	Abacavir hypersensitivity reaction in primary HIV infection.	AIDS (London, England)	20
13	16868443	Littera et al.	2006	HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients.	AIDS (London, England)	20
14	16981842	Alfirevic et al.	2006	HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.	Pharmacogenomics	7
15	17339877	Hirata et al.	2008	Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study.	The pharmacogenomics journal	8
16	17505501	Kindmark et al.	2008	Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis.	The pharmacogenomics journal	8
17	17509004	Man et al.	2007	Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.	Epilepsia	48
18	18184080	Rodríguez-Nóvoa et al.	2007	Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.	AIDS research and human retroviruses	23
19	18192896	Lonjou et al.	2008	A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs.	Pharmacogenetics and genomics	18
20	18505179	Almeida et al.	2008	Cytokine profiling in abacavir hypersensitivity patients.	Antiviral therapy	13
21	18637831	Locharernkul et al.	2008	Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population.	Epilepsia	49
22	19017052	Kashiwagi et al.	2008	Human leukocyte antigen genotypes in carbamazepine-induced severe cutaneous adverse drug response in Japanese patients.	The Journal of dermatology	35
23	19018717	Kaniwa et al.	2008	HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.	Pharmacogenomics	9
24	19104471	Chantarangsu et al.	2009	HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients.	Pharmacogenetics and genomics	19
25	19195327	Rauch et al.	2008	Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort Study.	Antiviral therapy	13
26	19374512	Alfirevic et al.	2009	TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.	Pharmacogenomics	10
27	19392989	Lee et al.	2009	The HLA allele marker for differentiating ASA hypersensitivity phenotypes.	Allergy	64
28	19483685	Daly et al.	2009	HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.	Nature genetics	41
29	19668019	Kazeem et al.	2009	High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients.	Pharmacogenetics and genomics	19
30	19696695	Tassaneeyakul et al.	2009	Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population.	Pharmacogenetics and genomics	19
31	19915237	Mehta et al.		Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.	Indian journal of dermatology, venereology and leprology	75
32	20235791	Hung et al.	2010	Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.	Pharmacogenomics	11
33	20345939	Tassaneeyakul et al.	2010	Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population.	Epilepsia	51
34	20639878	Singer et al.	2010	A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.	Nature genetics	42
35	20833111	Wu et al.	2010	Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China.	Epilepsy & behavior : E&B	19
36	21071176	An et al.	2010	Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population.	Epilepsy research	92
37	21149285	Ozeki et al.	2011	Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.	Human molecular genetics	20
38	21169036	Hu et al.	2011	Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population.	Seizure	20
39	21204807	Kaniwa et al.	2010	HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.	Epilepsia	51
40	21244392	Chang et al.	2011	Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population.	International journal of dermatology	50
41	21245432	Spraggs et al.	2011	HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer.	Journal of clinical oncology : official journal of the American Society of Clinical Oncology	29
42	21301380	Kang et al.	2011	Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans.	Pharmacogenetics and genomics	21
43	21306565	Shi et al.	2011	Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population.	Basic & clinical pharmacology & toxicology	109
44	21397523	Wang et al.	2011	Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland.	Seizure	20
45	21424386	Zhang et al.	2011	Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients.	European journal of clinical pharmacology	67
46	21428769	McCormack et al.	2011	HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.	The New England journal of medicine	364
47	21545408	Cristallo et al.	2011	A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis.	International journal of immunogenetics	38
48	21570397	Lucena et al.	2011	Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.	Gastroenterology	141
49	21676164	Kulkantrakorn et al.	2012	HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain.	Pain practice : the official journal of World Institute of Pain	12
50	21917426	Kim et al.	2011	Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans.	Epilepsy research	97
51	22053601	Then et al.	2011	Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients.	Asian Pacific journal of allergy and immunology	29
52	22197535	Berka et al.	2012	Human leukocyte antigen (HLA) and pharmacogenetics: screening for HLA-B*57:01 among human immunodeficiency virus-positive patients from southern Alberta.	Human immunology	73
53	22211527	Niihara et al.	2012	HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population.	The Journal of dermatology	39
54	22348415	Chiu et al.	2012	Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong.	The British journal of dermatology	167
55	22348435	Shi et al.	2012	Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502?	Basic & clinical pharmacology & toxicology	111
56	22422616	Mammen et al.	2012	Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy.	Arthritis care & research	64
57	22818943	He et al.	2012	Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: incidence, features, risk factors and relation to HLA-B alleles.	Seizure	21
58	22909208	Cao et al.	2012	HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese.	Pharmacogenomics	13
59	23057547	Fuerst et al.	2012	HLA polymorphisms influence the development of skin rash arising from treatment with EGF receptor inhibitors.	Pharmacogenomics	13
60	23153709	Kim et al.	2013	Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen.	Tuberculosis (Edinburgh, Scotland)	93
61	23328091	Phillips et al.	2013	Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa.	Journal of acquired immune deficiency syndromes (1999)	62
62	23362284	Carr et al.	2013	Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population.	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	56
63	23551241	Manuyakorn et al.	2013	Phenobarbital-induced severe cutaneous adverse drug reactions are associated with CYP2C19*2 in Thai children.	Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology	24
64	23588310	Amstutz et al.	2013	HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children.	Clinical pharmacology and therapeutics	94
65	23600531	Gonçalo et al.	2013	HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population.	The British journal of dermatology	169
66	23669020	Niihara et al.	2013	HLA-B*58:01 strongly associates with allopurinol-induced adverse drug reactions in a Japanese sample population.	Journal of dermatological science	71
67	23692434	Cheung et al.	2013	HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese.	Epilepsia	54
68	23829937	Lv et al.	2013	The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a northern Han Chinese population.	BMC neurology	13
69	23830818	Li et al.	2013	Predictive markers for carbamazepine and lamotrigine-induced maculopapular exanthema in Han Chinese.	Epilepsy research	106
70	23874514	Stephens et al.	2013	HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity.	PloS one	8
71	24152261	Zhang et al.	2013	HLA-B*13:01 and the dapsone hypersensitivity syndrome.	The New England journal of medicine	369
72	24225276	Chong et al.	2014	Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore.	Archives of disease in childhood	99
73	24268988	Hsiao et al.	2014	Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations.	Journal of dermatological science	73
74	24322785	Genin et al.	2014	HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis.	The pharmacogenomics journal	14
75	24394201	Toh et al.	2014	Building pharmacogenetics into a pharmacovigilance program in Singapore: using serious skin rash as a pilot study.	The pharmacogenomics journal	14
76	24399721	He et al.	2013	Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China.	Pharmacological reports : PR	65
77	24687830	Schaid et al.	2014	Prospective validation of HLA-DRB1*07:01 allele carriage as a predictive risk factor for lapatinib-induced liver injury.	Journal of clinical oncology : official journal of the American Society of Clinical Oncology	32
78	24781922	Ueta et al.	2014	Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.	Scientific reports	4
79	24856347	Wang et al.	2014	Genetic susceptibility to the cross-reactivity of aromatic antiepileptic drugs-induced cutaneous adverse reactions.	Epilepsy research	108
80	24899791	Furukawa et al.	2014	HLA-DRB1*08:02 Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients.	Biomarker insights	9
81	25099678	Ueta et al.	2014	Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications.	Scientific reports	4
82	25266342	Khor et al.	2014	HLA-B*15:02 association with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in an Indian population: a pooled-data analysis and meta-analysis.	Epilepsia	55
83	25303297	Yang et al.	2014	HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population.	Pharmacogenomics	15
84	25918017	Yang et al.	2016	HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese.	The pharmacogenomics journal	16
85	25938071	Nguyen et al.	2015	HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in Vietnamese.	Asia Pacific allergy	5
86	26086150	Kongpan et al.	2015	Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions.	Pharmacogenetics and genomics	25
87	26265500	Salvador et al.	2015	Evaluation of cytokine profile and HLA association in benznidazole related cutaneous reactions in patients with Chagas disease.	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	61
88	26282450	Moon et al.	2015	The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population.	Epilepsia	56
89	26632391	Park et al.	2016	HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.	Yonsei medical journal	57
90	26927288	Chang et al.	2017	Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population.	The pharmacogenomics journal	17
91	26928377	Tassaneeyakul et al.	2016	Associations between HLA class I and cytochrome P450 2C9 genetic polymorphisms and phenytoin-related severe cutaneous adverse reactions in a Thai population.	Pharmacogenetics and genomics	26
92	26959717	Nicoletti et al.	2016	HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.	Pharmacogenetics and genomics	26
93	26996548	Ng et al.	2016	Impact of the HLA-B(*)58:01 Allele and Renal Impairment on Allopurinol-Induced Cutaneous Adverse Reactions.	The Journal of investigative dermatology	136
94	27486401	Sukasem et al.	2016	HLA-B (*) 58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand.	Frontiers in pharmacology	7
95	27527109	Yang et al.	2017	HLA-B*51:01 is strongly associated with clindamycin-related cutaneous adverse drug reactions.	The pharmacogenomics journal	17
96	27666425	Moon et al.	2016	HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption.	Epilepsia	57
97	27749688	Yan et al.	2016	HLA-A*02 alleles are associated with tetanus antitoxin-induced exanthematous drug eruptions in Chinese patients.	Pharmacogenetics and genomics	26
98	27888155	Ramírez et al.	2017	Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population.	Pharmacological research	115
99	28043905	Nicoletti et al.	2017	Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.	Gastroenterology	152
100	28062682	Carr et al.	2017	Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.	The Journal of antimicrobial chemotherapy	72
101	28101480	Ramanujam et al.	2016	Spectrum of Cutaneous Adverse Reactions to Levetiracetam and Human Leukocyte Antigen Typing in North-Indian Patients.	Journal of epilepsy research	6
102	28278336	Wakamatsu et al.	2017	Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.	JAMA ophthalmology	135
103	28323125	Urban et al.	2017	Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B*35:02 as a risk factor.	Journal of hepatology	67
104	28351624	Kim et al.	2017	HLA-A*31:01 and lamotrigine-induced severe cutaneous adverse drug reactions in a Korean population.	Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology	118
105	28391407	Yampayon et al.	2017	Influence of genetic and non-genetic factors on phenytoin-induced severe cutaneous adverse drug reactions.	European journal of clinical pharmacology	73
106	28476759	Shi et al.	2017	HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.	Neurology	88
107	28570299	Khor et al.	2017	HLA-A*31: 01 and HLA-B*15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.	Pharmacogenetics and genomics	27
108	28596278	Kutszegi et al.	2017	HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia.	Haematologica	102
109	28786423	Spraggs et al.	2018	Characterisation of the HLA-DRB1*07:01 biomarker for lapatinib-induced liver toxicity during treatment of early-stage breast cancer patients with lapatinib in combination with trastuzumab and/or taxanes.	The pharmacogenomics journal	18
110	29053440	Yuliwulandari et al.	2017	Association of the HLA-B alleles with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in the Javanese and Sundanese population of Indonesia: the important role of the HLA-B75 serotype.	Pharmacogenomics	18
111	29125944	Ksouda et al.	2017	HLA-A*31:01 and carbamazepine-induced DRESS syndrom in a sample of North African population.	Seizure	53
112	29242946	Wu et al.	2018	Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China.	Acta dermato-venereologica	98
113	29575644	Chen et al.	2018	HLA-A*02:07 Allele Associates with Clarithromycin-Induced Cutaneous Adverse Drug Reactions in Chinese Patients.	Basic & clinical pharmacology & toxicology	123
114	30270535	Su et al.	2019	HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians.	Clinical pharmacology and therapeutics	105
115	30599396	Xu et al.	2019	Association between HLA-A*3201 allele and oxcarbazepine-induced cutaneous adverse reactions in Eastern Han Chinese population.	Seizure	65
116	30758654	Wang et al.	2019	Joint association of carrying HLA-B*13:01 gene and human herpesvirus-6 with occupational trichloroethylene hypersensitivity syndrome.	International archives of occupational and environmental health	92
117	30776417	Konvinse et al.	2019	HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.	The Journal of allergy and clinical immunology	144
118	30826555	Ihtisham et al.	2019	Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population.	Seizure	66
119	30972788	Mockenhaupt et al.	2019	HLA-B*57:01 confers genetic susceptibility to carbamazepine-induced SJS/TEN in Europeans.	Allergy
120	31089385	Esmaeilzadeh et al.	2019	Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics.	Iranian journal of pharmaceutical research : IJPR	18
Last Updated: Tuesday, September 10, 2019

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Ghattaoraya GS, Dundar Y, González-Galarza FF, Maia MH, Santos EJ, da Silva AL, McCabe A, Middleton D, Alfirevic A, Dickson R and Jones AR
A web resource for mining HLA associations with adverse drug reactions: HLA-ADR
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