Latest developments in AFND:
o New definition of geographical regions
o Data quality guidelines in AFND
o HLA Epitope Frequency section
o HLA and Adverse Drug Reactions section
o KIR and Disease Associations section

Introduction

The Allele Frequency Net Database (AFND) provides a central source, freely available to all, for the storage of allele frequencies from different polymorphic areas in the Human Genome. Users can contribute the results of their work into one common database and can perform database searches on information already available.

We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data.

Please cite this website using our last publication: Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 28, D784-8. [Full Text]

You should also cite the original publication report of the data in your references.

Polymorphic Region	Population Studies	Gene/Allele Data	Haplotype Data	Genotype Data
HLA	1025	1010	370	-
KIR	231	230	-	148
Cytokine	114	114	-	-
MIC	60	60	21	-
Totals	1,430	1,414	391	148

The current number of frequencies stored in our database is: 115,179 (HLA), 5,770 (KIR), 3,618 (Cytokine) and 760 (MIC) from 10,284,340 individuals.

We have updated the website with the new IMGT/HLA nomenclature guidelines.
IMGT/HLA last Update: 3.15.0, 17 January, 2014. | IPD-KIR last Update: 2.5.0, 11 October, 2013.

               

AFND is part of EUROSTAM (an FP7-HEALTH collaborative project) to facilitate transplantation of highly sensitized patients.

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