Allele Frequencies in World Populations
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The Allele Frequency Net Database



New collaboration with Human Immunology

As you know www.allelefrequencies.net (AFND) has collected frequency data for many years from normal populations We have now embarked with the journal HUMAN IMMUNOLOGY (HI) to collect individual genotype data from normal populations. The collection of this data will be the first step leading to a SHORT POPULATION REPORT in HI. The protocol and software tool has been developed on AFND for submission of this data. Once the dataset is submitted to AFND the investigator may then write a short publication for HI. The first announcement of this was made in HI 2015,76 393-94 and more details will be available in a review of AFND in an upcoming volume of HI.

If you have any queries please contact Derek.middleton@rlbuht.nhs.uk

New search available for low resolution data

We have included a new search in AFND to allow individuals to look for data at lower resolution. This allows an individual (when data is not available at high resolution for a specific allele) to search frequencies at a lower resolution for this allele family. You can find this link under our main menu (HLA -> Search frequencies at lower resolution).

Latest developments in AFND:
o New definition of geographical regions
o Data quality guidelines in AFND
o HLA Epitope Frequency section
o HLA and Adverse Drug Reactions section
o KIR and Disease Associations section

Introduction

Allele Frequencies in Worldwide Populations

The Allele Frequency Net Database (AFND) provides a central source, freely available to all, for the storage of allele frequencies from different polymorphic areas in the Human Genome. Users can contribute the results of their work into one common database and can perform database searches on information already available.

We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data.

Please cite this website using our last publication: Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 28, D784-8. [Full Text]

You should also cite the original publication report of the data in your references.

Database information


Polymorphic Region Population Studies Gene/Allele Data Haplotype Data Genotype Data
HLA10621047438 -
KIR239238 - 155
Cytokine121121 - -
MIC626221 -
Totals 1,484 1,468 459 155

The current number of frequencies stored in our database is: 118,450 (HLA), 5,899 (KIR), 4,037 (Cytokine) and 838 (MIC) from 10,297,609 individuals.

We have updated the website with the new IMGT/HLA nomenclature guidelines.
IMGT/HLA last Update: 3.20.0, 4 January, 2015. | IPD-KIR last Update: 2.6.0, 17 February, 2015.

               

AFND is part of EUROSTAM (an FP7-HEALTH collaborative project) to facilitate transplantation of highly sensitized patients.



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