Introduction

The Allele Frequency Net Database (AFND) provides the scientific community with a freely available repository for the storage of immune gene frequencies in different worldwide populations. Users can contribute the results of their work into one common database and can perform database searches on information already available. We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data.

Does any of this interest you?

• Would you like to publish your population frequency data on HLA and KIR? (In collaboration with Human immunology) See more information in Hum Immunol, 76, 393-394
• New search available for low resolution data when you cannot find the high resolution allele data you want

How good are the data sets in AFND?

We have classified HLA data sets into "Gold-Silver-Bronze" standards. If you wish to see how many populations are classified as Gold, click here.

Please cite this website using our last publication: Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations. Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 28, D784-8. [Full Text]
We recommend you to also cite the original publication report of the data in your references.

Polymorphic Region	Population Studies	Gene/Allele Data	Haplotype Data	Genotype Data
HLA	1232	1217	600	-
KIR	292	291	-	191
Cytokine	124	124	-	-
MIC	64	64	23	-
Totals	1,712	1,696	623	191

The current number of frequencies stored in our database is: 140,792 (HLA), 6,716 (KIR), 4,226 (Cytokine) and 877 (MIC) from 10,683,429 individuals.

We have updated the website with the new IMGT/HLA nomenclature guidelines.
IMGT/HLA last Update: 3.37.0, 10 July, 2019. | IPD-KIR last Update: 2.6.0, 17 February, 2015.