Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.

Allele: 
   

C*04:01

 
Allele reported 227 time(s) and present in 225 population(s).

Population Phenotype
Frequency (%)
Allele
Frequency
(in_decimals)
Sample
Size
IMGT/HLA¹
Database
Distribution² Haplotype³
Association
Notesª
MEXMexico Oaxaca Mixe0.378055See
MEXMexico Oaxaca Mixtec0.3730103See
USAUSA New Mexico Canoncito Navajo0.317042See
MEXMexico Oaxaca Zapotec0.306090See
IRNIran Baloch0.2860100See
AUSAustralia Cape York Peninsula Aborigine0.2750103See
AUSAustralia Yuendumu Aborigine0.2680191See
AUSAustralia Groote Eylandt Aborigine0.253075See
GHAGhana Ga-Adangbe42.00.2443131See
LBNLebanon Mixed0.243097See
USAUSA NMDP Caribean Black0.227933328See
ISRIsrael Arab Druze0.2250101See
GEOGeorgia Tibilisi Kurd0.224031See
BRABrazil Terena42.00.223060See
GEOGeorgia Tibilisi0.2200109See
MLIMali Bandiagara0.2130138See
TWNTaiwan Ami38.80.209098See
PNGPapua New Guinea Wanigela Keapara0.208066See
USAUSA NMDP African0.207228557See
USAUSA NMDP African American pop 20.2037416581See
USAUSA African American Bethesda35.10.1970187See
USAUSA African American pop 30.1960564See
SENSenegal Niokholo Mandenka0.1950165See
DEUGermany DKMS - Turkey minority0.19364856See
GRCGreece pop 833.70.192883See
CHLChile Easter Island0.190021See
ITAItaly South0.1880141See
CMRCameroon Beti0.1870174See
MEXMexico Mexico City Mestizo pop 20.1859234See
USAUSA African American pop 40.18462411See
DEUGermany DKMS - Greece minority0.18061894See
AUSAustralia Kimberly Aborigine0.179041See
USAUSA NMDP Hispanic South or Central American0.1756146714See
USAUSA NMDP Filipino0.171650614See
USAUSA NMDP Mexican or Chicano0.1710261235See
PNGPapua New Guinea Wosera Abelam0.1700131See
USAUSA NMDP Middle Eastern or North Coast of Africa0.168970890See
NCLNew Caledonia0.167065See
ITAItaly North pop 333.30.167097See
USAUSA Hispanic pop 20.16511999See
ITAItaly pop 50.1650975See
USAUSA Arizona Gila River Amerindian0.1630492See
UGAUganda Kampala pop 20.1600175See
MARMorocco Nador Metalsa pop 20.159073See
PRTPortugal Center pop 20.1580562See
USAUSA African American0.1570252See
CHESwitzerland Aargau-Solothurn0.15641838See
DEUGermany DKMS - Portugal minority0.15581176See
DEUGermany DKMS - Italy minority0.15541159See
PRTAzores Terceira Island0.1550130See
IRNIran Tehran0.1540120See
INDIndia Mumbai Maratha0.154091See
CMRCameroon Sawa0.154013See
PRTPortugal Azores Terceira Island27.20.1535130See
ESPSpain Sevilla26.60.1529278See
USAUSA South Texas Hispanic0.1520194See
USAUSA Hispanic0.1500234See
COLColombia Bogotá Cord Blood27.80.14901463See
USAUSA NMDP Caribean Hispanic0.1486115374See
CHESwitzerland Sion0.1485832See
PNGPapua New Guinea West Schrader Ranges Haruai0.148055See
ITAItaly North0.1480277See
ZWEZimbabwe Harare Shona0.1480230See
RUSRussia Karelia0.14761075See
GRCGreece pop 60.1467242See
CHESwitzerland Luzern0.14671553See
USAUSA San Diego26.60.1460496See
DEUGermany DKMS - Croatia minority0.14522057See
CHESwitzerland Geneva0.145080See
NICNicaragua Managua26.40.1447339See
AREUnited Arab Emirates Abu Dhabi0.144252See
ZMBZambia Lusaka0.144044See
USAUSA North American Native0.1420187See
UGAUganda Kampala0.1410161See
RUSRussia Bering Island Aleuts0.1394104See
CHESwitzerland Basel0.13891888See
DEUGermany DKMS - Romania minority0.13861234See
CHESwitzerland Zurich0.13774875See
CHESwitzerland Lugano0.13761169See
BRABrazil Mixed0.1370108See
USAUSA NMDP South Asian Indian0.1364185391See
DEUGermany DKMS - Bosnia and Herzegovina minority0.13521028See
SDNSudan Mixed24.00.1350200See
CHESwitzerland Bern0.13453545See
CHNChina Yunnan Bulang0.1340116See
FRAFrance West25.00.1339100See
CHNChina Tibet Region Tibetan0.1330158See
FINFinland0.133091See
KENKenya Luo0.1320265See
USAUSA NMDP North American Amerindian0.131235791See
PHLPhilippines Ivatan24.00.130050See
CMRCameroon Bamileke0.130077See
CHESwitzerland Lausanne0.1290993See
USAUSA Caucasian Bethesda23.50.1290307See
CZECzech Republic NMDR0.12875099See
DEUGermany DKMS - Spain minority0.12741107See
USAUSA Caucasian pop 40.12621070See
POLPoland DKMS0.125220653See
DEUGermany pop 80.125139689See
KENKenya, Nyanza Province, Luo tribe25.00.1250100See
LKASri Lanka Colombo22.70.1240714See
POLPoland0.1230200See
CHESwitzerland Graubunden0.1220759See
SGPSingapore Riau Malay0.1220132See
DEUGermany DKMS - France minority0.12061406See
ZAFSouth Africa Black0.1190200See
INDIndia Delhi pop 222.20.117090See
USAUSA Philadelphia Caucasian23.50.1170141See
DEUGermany pop 60.11688862See
CHLChile Santiago Mixed22.00.116870See
TUNTunisia22.00.1160100See
DEUGermany DKMS - Netherlands minority0.11551374See
USAUSA San Antonio Caucasian0.1152222See
DEUGermany DKMS - Austria minority0.11511698See
RUSRussia Tuva pop 20.1150169See
KENKenya Nandi0.1150240See
USAUSA NMDP Southeast Asian0.114827978See
TWNTaiwan Bunun22.80.1140101See
USAUSA Caucasian pop 20.1110265See
INDIndia West Coast Parsi0.110050See
ZAFSouth Africa Worcester21.00.1100159See
CHNChina Qinghai Province Hui0.1090110See
INDIndia Tamil Nadu0.10832492See
CZECzech Republic0.1080106See
CHESwitzerland St Gallen0.10762113See
INDIndia New Delhi0.107071See
USAUSA NMDP European Caucasian0.10591242890See
CHESwitzerland Geneva pop 20.10501267See
CHNChina Uyghur HIV negative0.105019See
ESPSpain Andalusia0.104099See
USAUSA San Francisco Caucasian0.1020220See
NLDNetherlands Leiden0.10201305See
NLDNetherlands UMCU18.80.101664See
MYSMalaysia Peninsular Malay19.20.1015951See
GBRUnited Kingdom pop 319.00.1010604See
ISRIsrael Ashkenazi and Non Ashkenazi Jews0.1010146See
SGPSingapore Javaneses0.100051See
JORJordan Amman0.1000146See
CMRCameroon Baka Pygmy0.100010See
CHNChina Beijing0.100067See
NZLNew Zealand Maori with Full Ancestry19.60.098046See
RUSRussian Federation - Transbaikal Territory - Buryats19.00.0970150See
SAUSaudi Arabia Guraiat and Hail18.50.0950213See
PNGPapua New Guinea Madang0.095065See
AUSAustralia New South Wales Caucasian0.0940134See
USAUSA Alaska Yupik0.0930252See
DEUGermany DKMS - United Kingdom minority0.09201043See
MEXMexico Chihuahua Tarahumara0.091044See
BGRBulgaria Gipsy0.091013See
DEUGermany Essen17.20.0900174See
FRAFrance Southeast16.90.0890130See
TWNTaiwan Paiwan17.60.088051See
ZAFSouth Africa Caucasians0.0880102See
NIRIreland Northern15.30.08301000See
VENVenezuela Sierra de Perija Yucpa0.083073See
CHNChina Inner Mongolia Region0.0830102See
RUSRussia North Ossetian16.50.0827127See
KORSouth Korea pop 10.0820324See
USAUSA Asian pop 20.08071772See
USAUSA South Dakota Lakota Sioux0.0740302See
CHNChina Sichuan HIV negative0.074034See
TWNTaiwan Atayal14.20.0710106See
INDIndia West Bhil0.070050See
TWNTaiwan Siraya13.70.069051See
PNGPapua New Guinea Karimui Plateau Pawaia0.069080See
CHNChina Shanxi HIV negative0.068022See
CHNChina North Han pop 20.0670567See
TWNTaiwan Thao13.30.067030See
KORSouth Korea pop 30.0660485See
JPNJapan pop 50.0650117See
DEUGermany DKMS - China minority0.06331282See
CHNChina Han HIV negative0.063072See
CHNChina Henan HIV negative0.063016See
ENGEngland North West11.40.0620298See
NZLNew Zealand Maori with Admixed History12.40.0620105See
THAThailand0.0600142See
USAUSA Asian0.0560358See
CHNChina Guangzhou0.0560102See
TWNTaiwan pop 20.0560364See
USAUSA NMDP Korean0.055677584See
IRLIreland South10.40.0540250See
VNMVietnam Hanoi Kinh pop 20.0530170See
COLColombia North Wiwa El Encanto0.048152See
NZLNew Zealand Polynesians with Full Ancestry9.50.048021See
CHNChina South Han pop 20.04781098See
TWNTaiwan Han Chinese0.0470504See
PNGPapua New Guinea Eastern Highlands Goroka Asaro0.047057See
JPNJapan Central0.0460371See
CHNChina Yunnan Province Han0.0450101See
CHNChina Canton Han0.0450264See
ESPSpain Andalusia Gipsy0.045099See
JPNJapan pop 160.044118604See
CHNChina South Han0.0440284See
USAUSA NMDP Chinese0.043499672See
JPNJapan pop 30.04301018See
ZAFSouth Africa Natal Tamil0.042051See
CHNChina Guizhou Province Miao pop 20.041085See
USAUSA NMDP Japanese0.040424582See
ASMAmerican Samoa0.040051See
HKGHong Kong Chinese BMDR0.03967595See
TWNTaiwan Saisiat7.80.039051See
USAUSA NMDP Vietnamese0.038343540See
NZLNew Zealand Polynesians with Admixed History7.40.037027See
JPNJapan pop 10.0360560See
JPNJapan Kyoto and Osaka0.0360165See
CHNChina Southwest Dai0.0360124See
PNGPapua New Guinea East New Britain Rabaul0.036060See
TWNTaiwan Minnan pop 16.90.0340102See
USAUSA Hawaii Okinawa0.0330106See
TWNTaiwan Puyuma6.00.030050See
INDIndia Khandesh Region Pawra0.030050See
MYSMalaysia Peninsular Chinese5.70.0284194See
TWNTaiwan Hakka5.50.027055See
CHNChina Yunnan Hani0.0230150See
TWNTaiwan Rukai4.00.020050See
TWNTaiwan Taroko3.60.018055See
SGPSingapore Thai0.0160100See
CAFCentral African Republic Mbenzele Pygmy3.00.015136See
VENVenezuela Perja Mountain Bari0.015055See
COLColombia North Chimila Amerindians0.010647See
TWNTaiwan Tsou2.00.010051See
TWNTaiwan Tao2.00.010050See
TWNTaiwan Pazeh1.80.009055See
CHNChina Guizhou Province Bouyei0.0050109See
CHNChina Guizhou Province Shui0.0000153See
BRABrazil Vale do Ribeira Quilombos0.20.0000144See
CHNChina North Han0.0000105See

Frequency data at lower resolution for this allele can be found in links below


Allele  Number of Populations 

Notes:

* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


   

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

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