Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 274 time(s) and present in 248 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
SWESweden Northern Sami0.3130154See
SWESweden Southern Sami0.2480130See
CZECzech Republic0.1890106See
NLDNetherlands UMCU29.70.187564See
RUSRussia Karelia0.16421075See
DEUGermany pop 60.15888862See
DEUGermany DKMS - Netherlands minority0.15211374See
DEUGermany DKMS - German donors0.15103456066See
USAUSA San Francisco Caucasian0.1480220See
DEUGermany pop 80.147439689See
NLDNetherlands Leiden0.14701305See
DEUGermany DKMS - France minority0.14651406See
NIRIreland Northern26.30.14301000See
CZECzech Republic NMDR0.14245099See
USAUSA San Antonio Caucasian0.1416222See
USAUSA NMDP European Caucasian0.13991242890See
USAUSA Caucasian pop 40.13831070See
ENGEngland North West25.50.1380298See
AUSAustralia New South Wales Caucasian0.1380134See
GEOGeorgia Svaneti Region Svan0.138080See
GEOGeorgia Tibilisi0.1380109See
DEUGermany DKMS - Austria minority0.13761698See
DEUGermany DKMS - United Kingdom minority0.13661043See
POLPoland DKMS0.131520653See
PAKPakistan Burusho0.130092See
RUSRussia Bering Island Aleuts0.1298104See
FRAFrance Southeast23.80.1270130See
USAUSA Caucasian pop 20.1260265See
PRTAzores Central Islands0.125059See
FRAFrance French Bone Marrow Donor Registry0.122642623See
DEUGermany DKMS - Croatia minority0.11982057See
USAUSA African American Bethesda23.80.1190187See
HRVCroatia pop 40.11844000See
DEUGermany DKMS - Romania minority0.11751234See
IRNIran Saqqez-Baneh Kurds0.116660See
IRLIreland South21.60.1160250See
DEUGermany DKMS - Spain minority0.11471107See
DEUGermany DKMS - Italy minority0.11231159See
DEUGermany DKMS - Portugal minority0.11111176See
PRTPortugal Azores Terceira Island21.90.1096130See
DEUGermany DKMS - Bosnia and Herzegovina minority0.10941028See
IRNIran Kurd pop 20.108060See
USAUSA Caucasian pop 30.108088See
IRNIran Yazd0.107156See
USAUSA Caucasian Bethesda20.60.1070307See
USAUSA NMDP American Indian South or Central America0.10605926See
PRTAzores Terceira Island0.1050130See
ARMArmenia combined Regions0.1050100See
CHNChina Uyghur HIV negative0.105019See
USAUSA NMDP North American Amerindian0.104435791See
ESPSpain (Catalunya, Navarra, Extremadura, Aaragón, Cantabria,19.50.10244335See
ITAItaly pop 50.1020975See
USAUSA NMDP Middle Eastern or North Coast of Africa0.101070890See
BRABrazil Belo Horizonte Caucasian17.90.100095See
USAUSA African American0.0990252See
INDIndia New Delhi0.098071See
IRNIran Tabriz Azeris0.097997See
ITAItaly North pop 319.20.097097See
GHAGhana Ga-Adangbe19.10.0954131See
DEUGermany DKMS - Turkey minority0.09434856See
CHNChina Han HIV negative0.094072See
CHNChina Henan HIV negative0.094016See
USAUSA African American pop 20.0940149See
USAUSA San Diego18.10.0920496See
ZAFSouth Africa Worcester18.00.0910159See
CHNChina Shanxi HIV negative0.091022See
PRTPortugal Center0.090050See
DEUGermany DKMS - Greece minority0.08821894See
PAKPakistan Mixed Pathan0.0870100See
GRCGreece pop 60.0868242See
AREUnited Arab Emirates Abu Dhabi0.086552See
USAUSA NMDP Caribean Hispanic0.0863115374See
CMRCameroon Beti0.0860174See
CUBCuba Caucasian15.70.086070See
CHLChile Mapuche0.084666See
GRCGreece pop 815.70.084383See
USAUSA NMDP African American pop 20.0839416581See
CUBCuba Mixed Race16.70.083042See
PRTPortugal South0.082049See
USAUSA NMDP Mexican or Chicano0.0815261235See
USAUSA African American pop 40.08132411See
INDIndia North UCBB16.20.08115849See
USAUSA NMDP Caribean Indian0.081014339See
INDIndia Andhra Pradesh Golla0.0800111See
ECUEcuador Amerindians0.079463See
USAUSA Hispanic pop 20.07911999See
USAUSA NMDP African0.078328557See
USAUSA NMDP Caribean Black0.078333328See
CMRCameroon Bamileke0.078077See
USAUSA NMDP Alaska Native or Aleut0.07701376See
PAKPakistan Kalash0.075069See
SAUSaudi Arabia Guraiat and Hail14.10.0750213See
INDIndia Central UCBB15.00.07484204See
USAUSA NMDP Hispanic South or Central American0.0738146714See
TUNTunisia Gabes0.073695See
USAUSA Hispanic0.0730234See
INDIndia Delhi pop 213.30.072090See
IRNIran Gorgan0.070064See
ISRIsrael Ethiopia Jews0.06995928See
RUSRussia Tuva pop 20.0690169See
INDIndia Tamil Nadu0.06762492See
NICNicaragua Managua13.20.0674339See
CHLChile Santiago Mixed13.00.067270See
USAUSA North American Native0.0670187See
INDIndia East UCBB13.30.06642403See
GNBGuinea Bissau Bijago0.065023See
PRTPortugal North0.065046See
PRTAzores Oriental Islands0.064043See
USAUSA NMDP South Asian Indian0.0636185391See
PAKPakistan Baloch0.063066See
SGPSingapore SGVP. Indian INS0.062086See
COLColombia Bogotá Cord Blood11.80.06121463See
INDIndia West UCBB12.10.06075829See
ISRIsrael Arab Druze0.0600101See
STPSao Tome Island Forro0.060066See
USAUSA South Texas Hispanic0.0600194See
ZAFSouth Africa Natal Zulu12.00.0600100See
ZMBZambia Lusaka0.058044See
INDIndia North pop 20.058072See
INDIndia South UCBB11.50.057311446See
MEXMexico Chihuahua Chihuahua City Pop 211.40.056888See
UGAUganda Kampala0.0550161See
USAUSA Philadelphia Caucasian21.50.0540141See
LKASri Lanka Colombo10.80.0540714See
MEXMexico Veracruz Xalapa10.70.053684See
BRABrazil Puyanawa10.70.0530150See
MEXMexico Mexico City Mestizo population0.0524143See
JORJordan Amman0.0520146See
BRABrazil Mixed0.0510108See
CMRCameroon Baka Pygmy0.050010See
USAUSA NMDP Southeast Asian0.049927978See
MYSMalaysia Peninsular Indian10.00.0498271See
TZATanzania Maasai9.60.0493336See
MYSMalaysia Kedah Kensiu9.50.048021See
SDNSudan Mixed9.50.0480200See
ISRIsrael Arab pop 20.047112301See
PAKPakistan Brahui0.0460104See
INDIndia Northeast UCBB9.10.0456296See
CHNChina Beijing0.045067See
AUSAustralia Cape York Peninsula Aborigine0.0440103See
PAKPakistan Mixed Sindhi0.0440101See
MLIMali Bandiagara0.0440138See
MEXMexico Mexico City Tlalpan8.80.0439330See
UGAUganda Kampala pop 20.0430175See
ZWEZimbabwe Harare Shona0.0400230See
ZAFSouth Africa Natal Tamil0.040051See
SENSenegal Niokholo Mandenka0.0380165See
CMRCameroon Sawa0.038013See
KENKenya Luo0.0360265See
MYSMalaysia Kelantan7.10.036028See
ISRIsrael Kavkazi Jews0.03562840See
ISRIsrael Ashkenazi and Non Ashkenazi Jews0.0340146See
USAUSA NMDP Hawaiian or other Pacific Islander0.032311499See
MEXMexico Mexico City Mestizo pop 20.0321234See
KENKenya Nandi0.0310240See
STPSao Tome Island Angolar0.031032See
ISRIsrael Morocco Jews0.030736718See
DEUGermany DKMS - China minority0.03011282See
CHNChina Jiangsu Province Han0.0297334See
ISRIsrael USSR Jews0.029445681See
CHNChina Jiangsu Han0.02903238See
CHNChina Beijing Shijiazhuang Tianjian Han0.0290618See
CHNChina Sichuan HIV negative0.029034See
CHNChina Guangzhou0.0290102See
NZLNew Zealand Maori with Admixed History5.70.0290105See
COLColombia North Wiwa El Encanto0.028852See
ISRIsrael Ashkenazi Jews pop 30.02844625See
ISRIsrael Georgia Jews0.02794471See
USAUSA Asian pop 20.02601772See
CHNChina Yunnan Province Nu0.0250107See
ISRIsrael Poland Jews0.024913871See
MEXMexico Mestizo4.90.024041See
IDNIndonesia Java Western4.70.0240236See
ISRIsrael Bukhara Jews0.02172317See
GNBGuinea Bissau Balanta0.021048See
GNBGuinea Bissau Papel0.020025See
ASMAmerican Samoa0.020051See
MYSMalaysia Patani4.00.020025See
SGPSingapore Javaneses0.020051See
USAUSA NMDP Korean0.019177584See
ESPSpain Andalusia Romani0.019099See
ISRIsrael Libya Jews0.01883739See
KORSouth Korea pop 30.0180485See
KORSouth Korea pop 100.01764128See
CHNChina Hubei Han3.50.01733732See
ARGArgentina Rosario Toba3.50.017086See
CHNChina Canton Han0.0170264See
USAUSA South Dakota Lakota Sioux0.0170302See
RUSRussian Federation Vologda Region3.40.0168119See
CHNChina South Han0.0160284See
GNBGuinea Bissau Fula0.016031See
ISRIsrael Iraq Jews0.015913270See
ISRIsrael USA Jews0.01556058See
KENKenya, Nyanza Province, Luo tribe3.00.0150100See
CHNChina Yunnan Province Han0.0150101See
ISRIsrael Tunisia Jews0.01409070See
USAUSA NMDP Chinese0.014099672See
AUSAustralia Kimberly Aborigine0.014041See
ISRIsrael Argentina Jews0.01324307See
USAUSA NMDP Filipino0.013150614See
CHNChina Marrow Donor Registry0.0130600See
NCLNew Caledonia0.012065See
ISRIsrael Iran Jews0.01188153See
PAKPakistan Karachi Parsi0.011091See
HKGHong Kong Chinese cord blood registry0.01093892See
MYSMalaysia Peninsular Malay2.10.0105951See
HKGHong Kong Chinese BMDR0.01037595See
USAUSA Asian0.0100358See
USAUSA NMDP Vietnamese0.009743540See
ISRIsrael YemenJews0.009615542See
USAUSA NMDP Japanese0.009024582See
ISRIsrael Druze0.00885914See
HKGHong Kong Chinese1.60.0080569See
MEXMexico Tixcacaltuyub Maya0.007567See
MEXMexico Oaxaca Zapotec0.007090See
SGPSingapore Chinese1.30.0070149See
MEXMexico Chiapas Lacandon Mayans0.0069218See
CHNChina Yunnan Province Lisu0.0060111See
SGPSingapore Chinese Han0.006094See
SGPSingapore SGVP Malay MAS0.006089See
USAUSA Alaska Yupik0.0060252See
TWNTaiwan Han Chinese0.0060504See
TWNTaiwan Tzu Chi Morrow Donor Registry0.005246682See
TWNTaiwan Tzu Chi Cord Blood Bank0.0050710See
SGPSingapore Thai0.0050100See
CHNChina Southwest Dai0.0040124See
JPNJapan pop 160.004018604See
JPNJapan Central0.0040371See
RUSRussia Belgorod region0.70.0033153See
AUSAustralia Yuendumu Aborigine0.0030191See
MYSMalaysia Peninsular Chinese0.50.0026194See
TWNTaiwan Tzu Chi Morrow Donor Registry Aborigine0.0021233See
TWNTaiwan pop 20.0020364See
USAUSA Arizona Gila River Amerindian0.0020492See
JPNJapan pop 30.00201018See
MEXMexico Oaxaca Mixtec0.0000103See
CHNChina North Han0.0000105See
BRABrazil Vale do Ribeira Quilombos0.10.0000144See
TWNTaiwan Tsou0.00.000051See
TWNTaiwan Rukai0.00.000050See
TWNTaiwan Paiwan0.00.000051See
TWNTaiwan Ami0.00.000098See
TWNTaiwan Puyuma0.00.000050See
TWNTaiwan Tao0.00.000050See
TWNTaiwan Pazeh0.00.000055See
TWNTaiwan Siraya0.00.000051See
TWNTaiwan Thao0.00.000030See
TWNTaiwan Minnan pop 10.00.0000102See
TWNTaiwan Hakka0.00.000055See
TWNTaiwan Atayal0.00.0000106See
TWNTaiwan Taroko0.00.000055See
TWNTaiwan Saisiat0.00.000051See
TWNTaiwan Bunun0.00.0000101See
SGPSingapore SGVP Chinese CHS0.000096See
PHLPhilippines Ivatan0.00.000050See
PNGPapua New Guinea Eastern Highlands Goroka Asaro0.000057See
PNGPapua New Guinea Madang0.000065See
PNGPapua New Guinea East New Britain Rabaul0.000060See
PNGPapua New Guinea West Schrader Ranges Haruai0.000055See
PNGPapua New Guinea Karimui Plateau Pawaia0.000080See
PNGPapua New Guinea Wosera Abelam0.0000131See
PNGPapua New Guinea Wanigela Keapara0.000066See

See also higher resolution data of this allele

Allele  Number of Populations 
 A*03:01:01 60 
 A*03:01:01:01 21 
 A*03:01:02 29 
 A*03:01:03 10 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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